Navigation Links
Low-dose naltrexone (LDN): Tricking the body to heal itself
Date:9/2/2011

n, Distinguished University Professor, and Dr. Patricia J. McLaughlin, Professor, along with Dr. Renee N. Donahue, in the Department of Neural & Behavioral Sciences. Drs. Zagon and McLaughlin not only discovered the phenomenon of LDN, and subsequently the OGF-OGFr axis, but have been at the forefront of translating their findings of LDN - and OGF - from the bench to the bedside. LDN has proven successful in Phase I and II clinical trials in the treatment of Crohn's disease, and OGF has been reported to be safe and efficacious for the treatment of advanced pancreatic cancer. Co-author Dr. McLaughlin states: "Now that we know LDN uses the OGF-OGFr axis as the pathway to control the cell cycle, this expands our arsenal of biological-based treatment modalities to bring about a change in disease states reliant on cell proliferation that not only includes LDN, but exogenous OGF and the imidazoquinoline, imiquimod. This information also provides the basis for a rational approach to the design of diagnostic tools and measures of therapeutic efficacy." Dr. Donahue, who has devoted a concentrated effort on improving the health of women through research explains: "This study joins a series of other investigations (Amer. J. Physiol. 296:R1716-1725, 2009; ibid, 297:R1154-R1161, 2009; Gynecol. Oncol. 122:382-388, 2011; J. Cancer Therapy 2:110-124, 2011; Exp. Biol. Med., in press, 2011) demonstrating that both LDN and OGF offer powerful treatments to combat a devastating cancer that strikes over 20,000 women in the U.S. each year and stands as the 5th leading cause of cancer-related deaths in females. Thus, one should not lose sight that the OGF-OGFr axis is a new frontier in understanding the pathogenesis and treatment of a cancer that has been, up to now, recalcitrant to conventional therapies." Dr. Zagon adds that "The exciting results that the mechanism of LDN uses the OGF-OGFr axis, brings together two very important opioid-based treatment modalities under one umbrella.
'/>"/>
Contact: Dr. Ian Zagon
isz1@psu.edu
717-531-6409
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Epigenetics could help researchers determine any risks associated with low-dose radiation
2. Low dose naltrexone (LDN): Harnessing the bodys own chemistry to treat human ovarian cancer
3. Is oil pricing itself out of the market?
4. Scientists discover cause of rare skin cancer that heals itself
5. Neisseria meningitidis disseminates itself by sending out scouts
6. Africa can feed itself in a generation: Study
7. Wildflower armors itself against disease
8. Your body recycling itself -- captured on film
9. A window that washes itself?
10. No longer a gray area: Our hair bleaches itself as we grow older
11. Biodiversity itself begets a species cascade, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ( ... Market Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market is estimated ... 2019. Although the U.S. market holds a larger share in ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... entomologists are set to meet next week at the ... as the North Central Branch of the Entomological Society ... topics will include public health/bed bug entomology, biocontrol of ... and Sontrol tactics, soybean aphid management, and insect biodiversity ...
... -- It,s a cloak that surpasses all others: a ... the way bacteria and other cells are imaged. ... State University, and his research team are wrapping bacteria ... under electron microscopes. Berry,s method creates a carbon cloak ...
... , This release is available in Spanish ... grass breeder has rediscovered a forage grass that seems just ... of an unusual forage grass led Michael Casler, an Agricultural ... Research Center in Madison, Wis., to identify the grass as ...
Cached Biology News:All wrapped up: K-State researcher's graphene cloak protects bacteria, leading to better images 2All wrapped up: K-State researcher's graphene cloak protects bacteria, leading to better images 3Dairy farmer finds unusual forage grass 2
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)...   GenoSpace , a precision medicine software company that has ... use of genomic, imaging and other biomedical data in research ... Munson , CEO of Aspera, an IBM Company, to its ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to welcome ...
(Date:12/24/2014)... 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), a ... today that the Company closed its previously announced ... Jack W. Schuler , Birchview Fund LLC ... million, before offering expenses.  The proceeds will be ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... no yellow tape or chalk outlines of a body, but ... want remedies, said a lawyer who spoke at the ... a partner with Michael Best & Friedrich , said ... or disgruntled employees can benefit from learning to work with ...
... a warning for chief information officers: By 2007, 80 percent ... executives. The CEO of Paragon Development Systems , an ... to stay involved with the business side of their companies ... change in a really short period of time," he said. ...
... If, five years ago, you asked a group of ... have said storage capacity, security or bandwidth. , ,Today, ... spate of securities legislation, highlighted by Congress's passage of ... has come to be called. SOX, which was passed ...
Cached Biology Technology:After a successful attack on your computer systems, then what? 2After a successful attack on your computer systems, then what? 3IT outsourcing remains on the horizon as companies focus on core business 2IT outsourcing remains on the horizon as companies focus on core business 3With Sarbanes-Oxley, compliance takes center stage for CIOs 2With Sarbanes-Oxley, compliance takes center stage for CIOs 3
... of BAC (100+kb), fosmid (40kb), and large ... than any othe BAC vector. On command ... and easy recombinant DNA purification. Available with ... VC) vectors for the highest insert stability. ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
RABBIT ANTI GLYCINE...
Request Info...
Biology Products: