Navigation Links
Low-cost sterilization method for cats and dogs is focus of new research project
Date:7/17/2013

WINSTON-SALEM, N.C. July 18, 2013 As an expert in molecular genetics, Colin E. Bishop, Ph.D.'s, usual role at the Wake Forest Baptist Medical Center's Institute for Regenerative Medicine is to apply the techniques of genetics and developmental biology to the regeneration of human organs.

But, with a background specifically in reproductive genetics, Bishop is also on a mission to help solve the over-population of homeless dogs and cats. Bishop has been awarded a two-year pilot grant from Michelson Prize and Grants (MPG), a division of the Found Animals Foundation, to develop a one-shot, non-surgical method for sterilizing companion animals.

According to MPG, an estimated six million to eight million cats and dogs enter U.S. shelters and three to four million of these animals are euthanized. Bishop is one of about 20 grant recipients worldwide working on developing non-surgical, single dose sterilization technology. The foundation will award a $25 million prize to the first research entity to develop a successful product.

Bishop's approach is to develop an injection to destroy particular cells in the hypothalamus, an area in the brain about the size of a pearl that controls reproduction in mammals. Because brain cells do not regenerate, it is believed that the treatment will lead to permanent sterility in the animals. Just like neutering or spaying, this method has the potential to eliminate the unwanted mating behaviors of companion animals without affecting their general health.

Specifically, the treatment aims to destroy GnRH cells in the hypothalamus that stimulate hormones that control male and female fertility. Bishop is designing a novel system for delivering a toxin to the GnRH cells. He will engineer nano-sized packages called exosomes that are generated from adult stem cells. These packages will be tagged to carry the molecular "address" of the GnRH cells, so that other cell types will not be affected. Inside the package will be a deadly "message" a toxin derived from influenza-A that is designed to bind with and kill the GnRH cells.

The milestones of the two-year project include generating engineered exosomes from mouse stem cells and evaluating their potential to fuse with the GnRH cells. The team will then load the exosomes with the toxin and test their ability to kill GnRH cells in a laboratory setting and in mice.

The ultimate goal of MPG and the Found Animals Foundation is "to end shelter euthanasia of healthy, adoptable animals." According to the Found Animals website, a one-shot sterilization method could also be used internationally to reduce the population of homeless dogs and cats.


'/>"/>

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Related biology news :

1. Low-cost in-vitro fertilization method developed at CU may help couples in developing countries
2. Low-cost nano-biosensor to detect foodborne pathogen that causes listeriosis
3. Can algae-derived oils support large-scale, low-cost biofuels production?
4. Plants provide accurate low-cost alternative for diagnosis of West Nile Virus
5. Students create low-cost biosensor to detect contaminated water in developing nations
6. Low-cost carbon capture gets X-rayed
7. Low-cost nanosheet catalyst discovered to split hydrogen from water
8. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
9. Researchers create method to rapidly identify specific strains of illness
10. Gasification method turns forest residues to biofuel with less than a euro per liter
11. Gasification method turns forest residues to biofuel with less than a euro per litre
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... , Nov. 29, 2016 BioDirection, a ... point-of-care products for the objective detection of concussion and ... company has successfully completed a meeting with the U.S. ... Tbit™ blood test Pre-Submission Package. During the meeting company ... system as a precursor to commencement of a planned ...
(Date:11/28/2016)... "The biometric system market ... The biometric system market is in the growth stage ... future. The biometric system market is expected to be ... CAGR of 16.79% between 2016 and 2022. Government initiative ... in smartphones, rising use of biometric technology in financial ...
(Date:11/22/2016)... MINNETONKA, Minn. , Nov. 22, 2016   ... that supports the entire spectrum of clinical research, is ... by Medical LiveWire Healthcare and Life Sciences Awards ... This award caps off an unprecedented year of recognition ... clinical trials for over 15 years. iMedNet ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... - Resverlogix Corp. ("Resverlogix" or the "Company") (TSX:RVX) ... Monitoring Board (DSMB) for the Company,s Phase 3 ... has completed a second planned safety review and ... without any modifications. The DSMB reviewed available study ... concerns were identified. The DSMB will conduct additional ...
(Date:12/5/2016)... Research and Markets has announced the ... Technologies, Markets and Companies" to their offering. ... , , ... human genome variations, development of sequencing technologies, and their applications. ... companies developing them. Various applications of sequencing are described including ...
(Date:12/4/2016)... San Francisco, CA (PRWEB) , ... December 03, ... ... scientific grants to ground-breaking microbiome studies. A microbiome impact grant award has been ... study the effect of heavy smoking and drinking on the oral microbiome. Grant ...
(Date:12/2/2016)... ... December 02, 2016 , ... In anticipation of AxioMed’s ... disc production, company President, Jake Lubinski will be traveling to Switzerland from December ... in Bern, Lucerne, and Zurich to discuss the benefits of a viscoelastic disc. ...
Breaking Biology Technology: