Navigation Links
Low-cost, ultra-fast DNA sequencing brings diagnostic use closer
Date:5/19/2010

BOSTON (5-19-10) -- Sequencing DNA could get a lot faster and cheaper and thus closer to routine use in clinical diagnostics thanks to a new method developed by a research team based at Boston University. The team has demonstrated the first use of solid state nanopores tiny holes in silicon chips that detect DNA molecules as they pass through the pore to read the identity of the four nucleotides that encode each DNA molecule. In addition, the researchers have shown the viability of a novel, more efficient method to detect single DNA molecules in nanopores.

"We have employed, for the first time, an optically-based method for DNA sequence readout combined with the nanopore system," said Boston University biomedical engineer Amit Meller, who collaborated with other researchers at Boston University, and at the University of Massachusetts Medical School in Worcester. "This allows us to probe multiple pores simultaneously using a single fast digital camera. Thus our method can be scaled up vastly, allowing us to obtain unprecedented DNA sequencing throughput."

The research is detailed in Nano Letters [http://pubs.acs.org/doi/abs/10.1021/nl1012147]. The National Institutes of Health are currently considering a four-year grant application to further advance Meller's nanopore sequencing project.

This low-cost, ultra-fast DNA sequencing could revolutionize both healthcare and biomedical research, and lead to major advances in drug development, preventative medicine and personalized medicine. By gaining access to the entire sequence of a patient's genome, a physician could determine the probability of that patient developing a specific genetic disease.

The team's findings show that nanopores, which can analyze extremely long DNA molecules with superior precision, are uniquely positioned to compete with current, third-generation DNA sequencing methods for cost, spe
'/>"/>

Contact: Michael Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
Source:Eurekalert

Page: 1 2

Related biology news :

1. CU physicists use ultra-fast lasers to open doors to new technologies unheard of just years ago
2. Sequencing of first frog genome sheds light on treating disease
3. New Stanford tool enables wider analyses of genome deep sequencing
4. First whole genome sequencing of family of 4 reveals new genetic power
5. Sequencing, annotation and comparative analysis of nine BACs of giant panda (Ailuropoda melanoleuca)
6. Genomatix gives a hand in the analysis of Wayne States sequencing projects
7. Life Technologies, TGen and US Oncology partner on groundbreaking breast cancer sequencing research
8. DNA sequencing unlocks relationships among flowering plants
9. Successful genome sequencing of pea aphid is a breakthrough for ecology and agricultural research
10. Genome sequencing of 3 parasitoid wasp species
11. ASU scientists develop universal DNA reader to advance faster, cheaper sequencing efforts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... Auguste, associate professor, biomedical engineering, in the Grove ... New York, have identified a molecule that could ... most aggressive forms of breast cancer. , Triple ... rate owing to aggressive proliferation and metastasis and ... Auguste,s team, discovered the overexpression of intercellular adhesion ...
(Date:11/7/2014)... November 6, 2014 Leading Biometric companies ... mobile security revolutionizing online transactions.  Companies in focus today are: ... (NYSE: BABA ), Google Inc. (NASDAQ: ... Inc. (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: ... and NXTDW), a biometric authentication company focused on the growing ...
(Date:11/6/2014)... Most cancer deaths occur because of metastasis, yet ... has been slow. , "It,s been particularly challenging ... Taran Gujral, research fellow in systems biology at ... aren,t detected until after they,ve already metastasized." , ... culprit that should help researchers better understand how ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Migration negation 2Migration negation 3
... lizard,s tolerance to cold is stiffer than scientists had suspected. ... Anolis cristatellus has adapted to the cooler winters ... be able to tolerate temperature variations caused by climate change. ... a problem for lizards. It is a major problem. However, ...
... there,s life even in brine beneath 60 feet of ... Lake Vida, located in the northernmost of the McMurdo Dry ... it is home to some newly discovered hearty microbes. In ... Academy of Sciences , Nathaniel Ostrom, Michigan State University zoologist, ...
... the brain called the orbitofrontal cortex is responsible for decisions ... made based on prior experience or habit, according to a ... University of Maryland School of Medicine and the National Institute ... area of the brain was responsible for both types of ...
Cached Biology News:Rapid changes in climate don't slow some lizards 2Hearty organisms discovered in bitter-cold Antarctic brine 2University of Maryland School of Medicine, NIH study pinpoints brain area's role in learning 2University of Maryland School of Medicine, NIH study pinpoints brain area's role in learning 3
(Date:11/21/2014)... Alto, Calif. (PRWEB) November 20, 2014 ... a nonprofit, public policy research organization representing leading ... pharmaceutical firms, and PwC US today ... states in life sciences industry growth. The trend ... 2013. The 2015 California Biomedical Industry Report ...
(Date:11/21/2014)... 2014 Deep Research Report on ... professional and in-depth research report on the Sodium ... like its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... US, Europe, Asia, China, Japan etc. regions) industry ...
(Date:11/21/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... September 30, 2014.  Biorem,s complete 2014 third quarter financial statements and ... Financial Summary:Three-months ended September 30, , Nine-months ended ... , 2014 , 2013 , 2014 ... 5,281 , 6,715 , 14,476 Gross profit ...
(Date:11/18/2014)... CA (PRWEB) November 17, 2014 Athena Signature ... Salk , Dr. Beverly Emerson, a professor in the Regulatory ... genes. Her most recent discovery points to an “off switch” ... Emerson’s career and how her local research is making a ... present her findings and then join host Cheryl K. Goodman, ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... April 14 febit,today announced its newest miRNA ... has been released by the Wellcome Trust Sanger ... most up-to-date,scientific information for miRNA microarray experiments., ... in the,field of genomics access to the latest ...
... Neptune Technologies &,Bioressources Inc. ("Neptune") (NASDAQ.NEPT - TSX.V.NTB) ... 2008 third quarter and,nine-month period ended February 29, ... achieved., Sales volume grew by 22% in ... the three-month period ended February 28, 2007 and ...
... ES Vascular Ltd. announced,today that it has ... Aortic Stapler,(OAS) system for mechanical suturing technology of ... other aortic reconstructions, enabling,commercialization of the device in ... the OAS stapler is a unique device that,enables ...
Cached Biology Technology:febit First to Offer miRBase 11.0 Biochip 2Neptune Technologies & Bioressources Inc. reports third quarter results and update on strategic milestones 2Neptune Technologies & Bioressources Inc. reports third quarter results and update on strategic milestones 3Neptune Technologies & Bioressources Inc. reports third quarter results and update on strategic milestones 4ES Vascular Receives CE Mark for its First Aortic Stapler for End-to-End Anastomosis Between Synthetic Grafts and Aorta During Open Repair of Aortic Aneurysmal and Occlusive Disease 2
... PCRx Enhancer System is used ... to optimize PCR of problematic ... PCRX Enhancer Solution with 10X ... primer specificity broader magnesium concentration ...
... Immunogen: Synthetic peptide derived from ... junctophilin-2. Specificity: Specific for the ... controls: mouse skeletal muscle homogenates frozen ... Western blotting Immunohistochemistry(froz) ImmunofluorescenceStorage: Store at ...
Abin-2 (N-16)...
CLIM-2 (T-16)...
Biology Products: