Navigation Links
Low cholesterol in immune cells tied to slow progression of HIV
Date:4/28/2014

y-off of the past three decades of meticulous data and specimen collection," said senior author Charles Rinaldo, Ph.D., chairman of Pitt Public Health's Department of Infectious Diseases and Microbiology, and professor of pathology. "It is thanks to our dedicated volunteer participants that we are making such important advances in understanding HIV, and applying it to preventing and treating AIDS."

Medications called combination antiretroviral therapy (ART) disrupt the viral replication process and can delay the onset of AIDS by decades.

However, even without taking ART, a small percentage of people infected with HIV do not have the persistent loss of T cells and increase in levels of HIV after initial infection. They can sometimes go many years, even more than a decade, without the virus seriously compromising the immune system or leading to AIDS.

Through the Pitt Men's Study/MACS, eight such "nonprogressors" were assessed twice a year for an average of 11 years and compared to eight typically progressing HIV-positive counterparts.

Dr. Rappocciolo and her colleagues found that in nonprogressors, the dendritic cells were not transferring the virus to T cells at detectible levels. When taking a closer look at these dendritic cells, the researchers discovered that the cells had low levels of cholesterol, even though the nonprogressors had regular levels of cholesterol in their blood. A similar finding was shown for B lymphocytes, which also pass HIV to T cells, leading to high rates of HIV replication.

Cholesterol is an essential component of the outer membranes of cells. It is required for HIV to replicate efficiently in different types of cells. None of the study participants were taking statins, which are cholesterol-lowering medications that some people take to prevent vascular problems when cholesterol in their blood is too high.

When HIV was directly mixed with the nonprogressors' T cells in the laboratory, thos
'/>"/>

Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study finds cancer-fighting goodness in cholesterol
2. Some HDL, or good cholesterol, may not protect against heart disease
3. Zebrafish research shows how dietary fat regulates cholesterol absorption
4. Vitamin D supplements do not improve cholesterol as previous research suggested
5. Host cholesterol secretion likely to influence gut microbiota
6. Cholesterol helps regulate key signaling proteins in the cell
7. Study identifies liver gene that regulates cholesterol and fat blood levels
8. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
9. Cholesterol rafts deliver drugs inside cancer cells
10. U-M researchers find new way to clear cholesterol from the blood
11. 4 genes indentified that influence levels of bad cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Low cholesterol in immune cells tied to slow progression of HIV
(Date:12/22/2014)... Research and Markets ( ... the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 ... the global digital media watermarking and fingerprinting ... piracy by securely and invisibly embedding identifiable ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( ... "Micro Market Monitor: North America Perimeter Security Systems Market" ... http://photos.prnewswire.com/prnh/20130307/600769 The North American perimeter ... of 3.6% from 2014 to 2019. Although the U.S. ... Canada is expected to grow at ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... #1 FOR IMMEDIATE RELEASE Bird flu virus remains ... Environmental Science & Technology Amid concerns ... for the first time that poultry carcasses infected with another ... in municipal landfills for almost 2 years. Their report is ...
... to reverse the effects of early-stage liver failure in some ... of losartan, a drug normally prescribed for hypertension, on 14 ... was at an advanced stage causing fibrosis - scarring in ... failure. Half of the patients in the trial saw ...
... University of Pennsylvania School of Medicine have uncovered variation around ... testicular cancer. Testicular cancer is the most common cancer among ... doubled in the last 40 years -- it now affects ... each year. The discovery, published in the May 31, 2009 ...
Cached Biology News:American Chemical Society's weekly PressPac -- May 27, 2009 2American Chemical Society's weekly PressPac -- May 27, 2009 3American Chemical Society's weekly PressPac -- May 27, 2009 4American Chemical Society's weekly PressPac -- May 27, 2009 5American Chemical Society's weekly PressPac -- May 27, 2009 6Liver disease 'shrunk' by blood-pressure drug 2Penn researchers discover genetic risk factor for testicular cancer 2Penn researchers discover genetic risk factor for testicular cancer 3
(Date:12/22/2014)... 2014  Alternative Energy & Environmental Solutions, Inc., ... a letter of intent to acquire BioTechPharma Corporation, ... a nanotechnology-based development platform used to create drug ... on-site collection and testing to identify infectious disease, ... an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)... 2014 ITRA Global, one of the ... commercial real estate, has further expanded its global reach ... and Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman ... ITRA Global / ACORPP (Australian Corporate Property and Projects) ... providing property services to a wide range of clients ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), ... promotion of Nick Maroulis, Pharm.D. to the newly created ... , In this position, Dr. Maroulis will continue to ... directors of our multi-site pharmacies as the company expands. ... during that time he has served in many different ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources Group ... grow at a 12 percent compound annual growth rate ... the aging population and the increasing adoption of dental ... will also spur demand for dental biomaterials ... implant and periodontal treatments. Other key findings ...
Breaking Biology Technology:ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3
... a week ago, we took a look at the PricewaterhouseCoopers quarterly ... quarter of 2003. As part of this analysis, we look at ... in the Midwest region. , ,This week, lets take a ... if there are any trends over time. Ready? Here we go! ...
... the planet Uranus, as viewed in this composite image, by ... Lawrence Sromovsky, UW-Madison Space Science and Engineering Center. Capitalizing ... scientists have gained an unprecedented look at the atmosphere of ... weather in the solar system. , ,A pair of images ...
... taglines pushing sales are great for getting a customers attention ... second or two. , ,Some taglines catch the users attention, ... trap and run away. , ,The combined yearly budgets of ... easily add up to billions of dollars. Corporations make extraordinary ...
Cached Biology Technology:Though VC investing is down, reloading on new funds is rising 2Though VC investing is down, reloading on new funds is rising 3UW space scientists use Keck telescope to study wild weather of Uranus 2UW space scientists use Keck telescope to study wild weather of Uranus 3Super advertising slogans, and super costs 2Super advertising slogans, and super costs 3Super advertising slogans, and super costs 4
... The standard electrophoresis hood ... gel documentation systems. Placed on ... camera in place and provides ... photography on the lab bench. ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7 microns ... large (3-5 mm in diameter) in comparison ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... from Paraffin embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 5 microns ... large (3-5mm in diameter) in comparison to ...
Biology Products: