Navigation Links
Low-calorie diet may be harmful for bowel disease patients
Date:3/20/2012

EAST LANSING, Mich. In a surprising result, Michigan State University researchers looking at the effects of diet on bowel disease found that mice on a calorie-restricted diet were more likely to die after being infected with an inflammation-causing bacterial pathogen in the colon.

While research suggests inflammation associated with obesity may contribute to inflammatory bowel diseases such as colitis, the study results revealed a low-calorie diet may actually impair the immune system's ability to respond to infection, said Jenifer Fenton, assistant professor in the Department of Food Science and Human Nutrition.

Additionally, the study found no connection that moderate obesity increased the severity of colitis in the mouse model.

"The results are similar to the research from our department that shows consuming fewer calories make it harder to fight off the flu virus," said Fenton, referring to recent work by colleague Elizabeth Gardner. "Since this is a totally different pathogen, it amplifies the need to find out why caloric intake has such an impact on the body's ability to respond to infection.

"It is possible that the same mechanism that happens with the flu is occurring with gastro-intestinal diseases; future research will ask this very question."

The research is published in the current edition of the World Journal of Gastroenterology.

Inflammatory bowel disease, or IBD, is a group of conditions affecting the colon and intestines; the major types being ulcerative colitis and Crohn's disease. People suffering from IBD have an increased risk of developing colon cancer.

As part of their study, Fenton and colleagues evaluated the influence of obesity and calorie-restricted diets on mice with induced colitis.

Mice in the study were given one of three dietary treatments: a high-fat diet, a 30 percent caloric-restriction diet and a control group on an average-caloric diet. They then were treated with bacteria called H. hepaticus, which infects the colon and causes inflammation, eventually leading to tumor development. This process models the more aggressive lesions observed in human colon cancer cases.

Unexpectedly, study results suggest increased body fat induced by a high-fat diet did not influence the severity of colitis, despite changes in hormones that are known to increase with obesity and influence inflammation. In fact, researchers found calorie-restricted mice had a higher mortality rate in response to infection with H. hepaticus, dying before tumors even developed.

"Future studies should examine the association between body fat percentage and immune responses to infections leading to inflammatory bowel diseases," Fenton said. "Understanding how a low-calorie diet increases mortality in this model may lead to new treatments for the disease in humans."


'/>"/>
Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related biology news :

1. International experts weigh-in on harmful algal blooms
2. Hot spot for toxic harmful algal blooms discovered off Washington coast
3. Potentially harmful chemicals found in forest fire smoke
4. Scientists report first remote, underwater detection of harmful algae, toxins
5. Airway cells use tasting mechanism to detect and clear harmful substances
6. Toward safer plastics that lock in potentially harmful plasticizers
7. Heat forms potentially harmful substance in high-fructose corn syrup
8. Smokeless tobacco called moist snuff is contaminated with harmful substances
9. Household detergents, shampoos may form harmful substance in wastewater
10. New research to improve management of harmful algal blooms in Puget Sound
11. Many urban streams harmful to aquatic life following winter pavement deicing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Low-calorie diet may be harmful for bowel disease patients
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... Avomeen Analytical Services, an ... its 2017 Science Student Award. The scholarship program is dedicated to helping those ... defray the costs of obtaining their science education. , Avomeen began the annual ...
(Date:9/18/2017)... ... 2017 , ... Transportable biomass conversion facilities and the economics ... the topic of a September 27 webinar hosted by the Waste ... biomass conversion facilities for producing biochar, briquettes, and torrefied wood, biomass supply chains ...
(Date:9/17/2017)... ... 2017 , ... GeneOne Life Science, Inc. announces that it ... (KMFDS) for an Investigational New Drug application for a Phase I/IIa study of ... study in Korea represents the second clinical trial for GLS-5300. , A ...
(Date:9/14/2017)... , ... September 14, 2017 ... ... the launch of its CliniControlâ„¢ (CC) product portfolio, clinically-relevant starting and ancillary ... translation of human Mesenchymal Stem/Stromal Cell (hMSC)-based therapies. The CliniControl product portfolio ...
Breaking Biology Technology: