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Low brain protein levels associated with neurodegeneration
Date:7/3/2014

ied out that patients with Alzheimer's disease or frontotemporal dementia tended to have low levels of TREM2 in their cerebrospinal fluid, while patients with FTD-like syndrome completely lacked this protein.

"Although we must still continue researching, these results suggest that the TREM2 protein plays a fundamental role in the elimination of amyloids and other protein aggregates and its malfunctioning can accelerate neurodegenerative processes. It could also be a useful indicator of neurodegenerative diseases", explains Marc Surez-Calvet, pre-doctoral researcher at the UAB and participant in the study.

The stimulation of TREM2 functions could be a useful strategy when fighting neurodegenerative diseases, the study indicates. "It would be good to continue with the research and observe if acting on the TREM2 to restore or increase its activity could be effective in treating different neurodegenerative pathologies", concludes Albert Lle, IBB researcher and lecturer at the UAB Department of Medicine.


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Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

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