Navigation Links
Low adherence to biopsy guidelines affects celiac disease diagnosis in the United States

NEW YORK, NY (July 6, 2011) - A new study has found that most patients undergoing biopsy of the small intestine do not have the recommended number of samples to diagnose celiac disease. The study, published in the July 2011 issue of Gastrointestinal Endoscopy, analyzed a national database of biopsy specimens maintained by Caris Life Sciences (Irving, TX). More than 100,000 patients had a biopsy of the small intestine, but only 35 percent of them had at least four samples taken, the number recommended by professional guidelines.

Celiac disease is common, affecting approximately 1 percent of the population in the United States. However, the vast majority of patients with celiac disease in the United States have not been diagnosed. Many of these patients seek health care for symptoms including diarrhea, weight loss, or fatigue due to anemia. The diagnosis of celiac disease is made by biopsy of the small intestine, but factors related to the performance of biopsy may contribute to the under-diagnosis of celiac disease in the United States.

"Celiac disease can affect the small intestine in a patchy distribution, and so just one or two biopsy samples could potentially miss the evidence of the disease," said lead author Benjamin Lebwohl, MD, MS, a gastroenterologist at the Celiac Disease Center at Columbia University Medical Center, in New York. Dr. Lebwohl and co-authors aimed to measure the practice of small intestinal biopsy in the United States. The Caris pathology database consists of specimens submitted by gastroenterologists from 43 states as well as Puerto Rico and the District of Columbia. The team also compared the diagnosis rate among patients who had at least four specimens submitted, in accordance with guidelines.

The investigators identified 132,352 individuals who underwent biopsy between 2006 and 2009, for a variety of medical indications, including diarrhea, abdominal pain, esophageal reflux, and anemia. Only 35 percent of this group had at least four specimens submitted, and the most common number of specimens submitted was two. But adhering to the recommendation of submitting at least four specimens more than doubled the diagnosis rate of celiac disease.

Even when physicians indicated that they were suspicious of celiac disease (e.g., when patients had positive celiac disease blood tests), fewer than 40 percent of patients had at least four specimens submitted; the diagnosis was increased sevenfold when the guidelines were followed.

"The process of increasing the number of specimens from two to four takes approximately one extra minute during endoscopy," said Dr. Lebwohl. Given the high incremental yield of submitting at least four specimens, taking this extra minute appears to be justified.

"In this study we identified just one of the factors contributing to the high rate of under-diagnosis of celiac disease in the United States. We plan on studying other physician-related factors that may also be operative," said Dr. Peter Green, Director of the Celiac Center Columbia University Medical Center, who was also an author on the paper.


Contact: Cynthai Beckman
Columbia University Medical Center

Related biology news :

1. Link between fracture prevention and treatment adherence not fully understood by patients
2. Novel technique changes lymph node biopsy, reduces radiaiton exposure
3. Novel technique changes lymph node biopsy, reduces radiation exposure
4. Montana State grads work helps diagnose skin cancer without a biopsy
5. Multicolor quantum dots aid in cancer biopsy diagnosis
6. Microfluidics-imaging platform detects cancer growth signaling in minute biopsy samples
7. Guidelines urge physical activity during pregnancy
8. The International Society for Stem Cell Research releases new guidelines
9. Publication sets guidelines across cancer therapies: Ensuring the best in patient management
10. Coral Disease Handbook: Guidelines for Assessment, Monitoring and Management
11. First comprehensive guidelines for managing medullary thyroid carcinoma published in Thyroid journal
Post Your Comments:
(Date:10/8/2015)... 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... wallet announces that revenues for the three months ... with $113,00 for the three months ended June ... September 30, 2015 were approximately $520,000. ...
(Date:10/6/2015)... Oct. 6, 2015 Track Group, Inc. (OTCQX: ... it has signed a contract with the Virginia Department ... full range of sentences under the Department,s oversight. ... Americas. "This contract with the Virginia DOC will expand ... and advances our position as a trusted leader in ...
(Date:10/2/2015)... 02 2015 ... "Enforcing the Law Using Biometrics" report to ... announced the addition of the "Enforcing the ... --> Research and Markets ( ... "Enforcing the Law Using Biometrics" report to ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... ... ... LifeTrak , a leader in consumer fitness, heart rate and activity ... tracker that seeks to meet the needs of multi-sport athletes. Zoom is the first ... both in water and on land, making it the only fitness tracker an athlete ...
(Date:10/10/2015)... 2015 Am 8. Oktober hat die ... für Kalifornien) ihre Würdigung der International Plasma Awareness ... Aufzeichnungen des Kongresses eintragen lassen. Die IPAW wird ... (PPTA) und ihren Mitgliedsunternehmen unterstützt. Ihre Ziele bestehen ... über Plasmaspenden weltweit , Würdigung des Beitrages ...
(Date:10/9/2015)... ROCKVILLE, Md. , Oct. 9, ... biotechnology company developing next generation vaccines based on ... entered into an exclusive worldwide licensing agreement with ... treatment or prevention of any and all allergic ... Immunomic Therapeutics will receive an upfront payment of ...
(Date:10/9/2015)... ... October 09, 2015 , ... From blood to ... separating those cells from their surroundings for research, diagnostics, and cell therapy—also known ... address this, Ann Arbor-based startup Akadeum Life Sciences is developing a ...
Breaking Biology Technology: