Navigation Links
Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
Date:10/13/2009

y (PET) scanning with the glucose analogue FDG - both in the mice and in humans - is a highly accurate way to distinguish between the benign tumors and the malignant ones, indicating that this non-invasive imaging technology is valuable in assessing therapeutic response to new treatments.

Wu created the mouse model with two of her graduate students, Caroline Gregorian and Jonathan Nakashima, co-first authors of this paper. It was created by altering two cell signaling pathways that are commonly activated in peripheral and central nervous system cancers, the RAS/RAF/MAPK & PTEN/P13K/AKT pathways, known to regulate cell proliferation, survival and differentiation.

"When we began to generate mouse models to mimic different human cancers, we usually did gene-based analysis to see the relevance of a specific gene in the development of the cancer," Wu said. "But we realize that sometimes targeting the cell signaling pathways that organize and instruct cells to function, both for normal functions of our body and also in abnormal ways in disease, are more important and informative than the individual gene"

The mouse model developed benign neurofibromas, but then progressed to the deadly sub-type of sarcoma. The neurofibromas had half the normal levels of PTEN and the sarcomas had a complete loss of PTEN. Since PTEN is an important factor in suppressing cells from becoming malignant, this could provide an explanation for the sequence of the normal cells transforming into benign neurofibromas that could then transform into cancer.

Wondering if this was also the case in people, Dr. Wu collaborated with Eilber and pathologist Dr. Sarah Dry, director of the Institute of Molecular Medicine's Pathway Pathology Center, and a multidisciplinary team of physician-scientists to determine if people with this sarcoma sub-type also had little or no PTEN.

"This type of collaboration is the hallmark of the work at the Jonsson Cancer Center a
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Invasion of the brain tumors
2. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
3. Bits of junk RNA aid master tumor-suppressor gene
4. Analysis of breast and colon cancer genes finds many areas of differences between tumors
5. Tumor genome analysis unveils new insights into lung cancer
6. Cell response to stress signals predicts tumors in women with common pre-breast cancer
7. Synthetic compound promotes death of lung-cancer cells, tumors
8. MIT: Remote-control nanoparticles deliver drugs directly into tumors
9. New X-ray technique targets terrorists and tumors
10. DNA methylation shown to promote development of colon tumors
11. Gene variation may elevate risk of liver tumor in patients with cirrhosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Millions of people in the United States have a ... It can be painful and may even require surgery ... skeletal muscle wasting and, in turn, limb amputation. , ... Houston (UTHealth) Medical School, scientists tested a non-surgical preventative ... it was associated with increased blood circulation. Their ...
(Date:7/28/2014)... Essigmann and colleagues from the University of Washington had a ... could induce the virus to mutate uncontrollably, they could force ... that our immune system uses against many viruses. , ... mutate at an enhanced rate, as expected. But it did ... trial reported in 2011. In a new study, however, Essigmann ...
(Date:7/28/2014)... suggests that the effects of a commonly used anesthetic ... , The study, published in this week,s issue of ... biologists at the University of California, San Diego and ... to concerns, arising from multiple studies on humans over ... may increase their susceptibility to long-term cognitive and behavioral ...
Breaking Biology News(10 mins):Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4Study suggests disruptive effects of anesthesia on brain cell connections are temporary 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 3
... has awarded $11.5 million to a consortium of research ... for the creation of a center for the study ... the X-ray Structure Determination of Human Transportersis one of ... "solve the structures of these elusive yet very medically ...
... UCLA has received a five-year, $12.5 million contract award from ... international consortium of medical experts that will study proteins that ... Heart disease is a leading killer worldwide, but ... or how the inner sub-units of a cardiac cell work ...
... scientists suggests that a class of material known as metallacarborane ... the United States Department of Energy (DOE) Hydrogen Program for ... comes into play as a fuel of the future for ... study by Rice theoretical physicist Boris Yakobson and his colleagues, ...
Cached Biology News:NIH awards $11.5 million for new Caltech-led membrane-protein center 2UCLA receives $12.5M to lead international project to study proteins implicated in heart disease 2Hydrogen fuel for thought 2
(Date:7/29/2014)... 2014 DisasterTalk is a texting app which ... phone masts or other transmitters are down. The app can ... without the need for any Wi-Fi, and can also use ... new app has launched as a housing report ... high risk of being affected by natural disasters. With the ...
(Date:7/29/2014)... TX (PRWEB) July 29, 2014 G-CON ... autonomous modular cleanrooms, today announced a new leadership appointment ... the United States and abroad. , Maik Jornitz, ... as the company’s President charged with leading the pioneering ... “As we enter this stage of development and look ...
(Date:7/29/2014)... Boston, MA (PRWEB) July 29, 2014 ... the Library of Congress was recently awarded to Juliana ... in Stoneham, MA, for their project, “From an Egg, ... from among 3,000 final entries for the National History ... more than 300 historians and educators in Washington, D.C. ...
(Date:7/29/2014)... EXpressLO LLC, expert provider of focused ion ... has been granted patent number 8,789,826 by the U.S. ... a unique specimen carrier support grid design described in ... patent for EXpressLO LLC awarded to founder and President, ... patents extend EXpressLO’s portfolio of intellectual property. The EXpressLO™ ...
Breaking Biology Technology:DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2
... announced today that its,Chief Financial Officer, Rick McCook, will ... July 2006., "I have enjoyed my work with ... my tenure," said McCook. "However, at this time I,intend ... to,more fully leverage my skills and experience.", "During ...
... 18 Osteotech, Inc.,(Nasdaq: OSTE ), a ... for,regenerative medicine, announced today that it has renewed ... Transplant Alliance,("EATA"), a Bulgarian public non-profit foundation. The ... an initial term of seven years and,automatically renews ...
... 18 ev3 Inc. (Nasdaq:,EVVV) will release its 2008 ... regular market trading hours., The company will host ... a.m. CT (8:30 a.m. ET). ev3 management will review ... a question and answer,session., The conference call will ...
Cached Biology Technology:Osteotech Renews Tissue Recovery Agreement with the Euro Atlantic Transplant Alliance 2Osteotech Renews Tissue Recovery Agreement with the Euro Atlantic Transplant Alliance 3
Mouse Anti-Human Methyl-CpG binding domain protein 2 (MBD2 Monoclonal Antibody Family: Other Applications: Western Blot...
... The 2/3D Waver Shaker combines shaking and ... with a 330 x 330 mm stainless steel ... top incubator and cold room operation. The platform ... degree for a vigorous with action and rotation ...
...
Monoclonal Anti-Cystatin A tissue culture supernatant Solution containing 15 mM sodium azide human cystatin A ...
Biology Products: