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Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
Date:12/3/2007

etinal tissue is rich with blood supply, and Lin and his colleagues were able to sample a greater number of blood vessels and a much larger volume of blood. In initial feasibility experiments, they monitored a million circulating cells in the mouse that were fluorescently labeled with a marker that allowed them to be spotted with a microscope. The cytometer allowed them to track these cells as they trafficked though the bloodstream. They could observe approximately 250 cells per minute, and over time statistically model the flow of the cells.

This new device is not designed for humans and has not been tested in clinical trials. As a laboratory tool, however, it will allow the team to observe what happens when different chemotherapy agents are given to rodentsa standard early approach for evaluating the effectiveness of new chemotherapy agents and treatment strategies for humans.


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Contact: Colleen Morrison
cmorri@osa.org
202-416-1437
Optical Society of America
Source:Eurekalert

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