Navigation Links
Looking at neurons from all sides
Date:4/27/2008

HOUSTON (April 28, 2008) A new technique that marries a fast-moving laser beam with a special microscope that look at tissues in different optical planes will enable scientists to get a three-dimensional view of neurons or nerve cells as they interact, said Baylor College of Medicine scientists in a report that appears today in the journal Nature Neuroscience.

Most microscopes can only study cell function in two dimensions, said Dr. Gaddum Duemani Reddy, an M.D./Ph.D. student at BCM at Houston and Rice University and also first author of the study. To look at different planes, you have move your preparation (of cells) or the objective lens. That takes time, and we are looking at processes that happen in milliseconds.

To solve that problem, he said, they developed a trick to quickly move a laser beam in three dimensions and then adapted that laser beam to the multi-photon microscope they were using. That allowed them to see the neurons function in three dimensions, giving them a much better view of its activity.

A multiphoton microscope looks much like a conventional, upright microscope but it has an adaption that allows it to look at tissues in sections. A conventional multiphoton microscope does that very slowly, he said.

With ours, you can do it very quickly. We are starting to see how a single neuron behaves in our laboratory, he said. The next step, he said, will be to use to it to look a clusters or colonies of neurons. This will enable them to actually see the neuronal interactions.

At present, the technology is applied in my lab to study information processing of single neurons in brain slice preparations by 3D multi-site optical recording, said Dr. Peter Saggau, professor of neuroscience at BCM and the papers senior author.

He is collaborating with two other labs on using the technology in other ways. In one, he said, researchers plan to use the technology to monitor nerve activity in the brains of lab animals in order study how populations of neurons communicate during visual stimulation. Another study attempts to use the technology to monitor stimulation of the acoustic nerve optically. Those scientists hope to reinstate hearing in lab animals whose inner ear receptors do not work.


'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4712
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
2. Inflammation triggers cell fusions that could protect neurons, Stanford research shows
3. Neurons hard wired to tell left from right
4. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
5. Overexcited neurons not good for cell health
6. The birth and death of dopamine neurons: A new model for neurodegeneration
7. The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
8. Mice use specialized neurons to detect carbon dioxide in the air
9. Sidestepping cancers chaperone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential ... use of DNA technology to an industry that is ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
Breaking Biology Technology: