Navigation Links
Looking at neurons from all sides
Date:4/27/2008

HOUSTON (April 28, 2008) A new technique that marries a fast-moving laser beam with a special microscope that look at tissues in different optical planes will enable scientists to get a three-dimensional view of neurons or nerve cells as they interact, said Baylor College of Medicine scientists in a report that appears today in the journal Nature Neuroscience.

Most microscopes can only study cell function in two dimensions, said Dr. Gaddum Duemani Reddy, an M.D./Ph.D. student at BCM at Houston and Rice University and also first author of the study. To look at different planes, you have move your preparation (of cells) or the objective lens. That takes time, and we are looking at processes that happen in milliseconds.

To solve that problem, he said, they developed a trick to quickly move a laser beam in three dimensions and then adapted that laser beam to the multi-photon microscope they were using. That allowed them to see the neurons function in three dimensions, giving them a much better view of its activity.

A multiphoton microscope looks much like a conventional, upright microscope but it has an adaption that allows it to look at tissues in sections. A conventional multiphoton microscope does that very slowly, he said.

With ours, you can do it very quickly. We are starting to see how a single neuron behaves in our laboratory, he said. The next step, he said, will be to use to it to look a clusters or colonies of neurons. This will enable them to actually see the neuronal interactions.

At present, the technology is applied in my lab to study information processing of single neurons in brain slice preparations by 3D multi-site optical recording, said Dr. Peter Saggau, professor of neuroscience at BCM and the papers senior author.

He is collaborating with two other labs on using the technology in other ways. In one, he said, researchers plan to use the technology to monitor nerve activity in the brains of lab animals in order study how populations of neurons communicate during visual stimulation. Another study attempts to use the technology to monitor stimulation of the acoustic nerve optically. Those scientists hope to reinstate hearing in lab animals whose inner ear receptors do not work.


'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4712
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
2. Inflammation triggers cell fusions that could protect neurons, Stanford research shows
3. Neurons hard wired to tell left from right
4. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
5. Overexcited neurons not good for cell health
6. The birth and death of dopamine neurons: A new model for neurodegeneration
7. The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
8. Mice use specialized neurons to detect carbon dioxide in the air
9. Sidestepping cancers chaperone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: