Navigation Links
Longevity mutation found in flies far and wide
Date:2/5/2014

t's great, but now we can show that it does it in the wild."

In the study, published online Jan. 31 in the journal Aging, the researchers, led by postdoctoral scholar Chen-Tseh Zhu, describe experiments that confirm that the Hoppel transposon's presence positively affected life span and fertility in the flies. What they found is that the optimal case for those two traits was heterozygosity: one allele, or copy, of the Indy gene in a fly having the insertion and the other not having it.

Life span and fertility

The researchers measured the physiological effects of Hoppel by looking at flies from three different lines: one from Oahu gathered in 1950s, another from Captain Cook, Hawaii, gathered in 2007, and one with its origin in Hidalgo, Mexico, in 2005. Each line had some flies with at least one copy of Indy with Hoppel and some with no Hoppel in Indy.

The heterozygous females in these lines ended up laying about 10 percent more eggs than flies that had no Indy alleles with Hoppel. Flies for whom both Indy alleles had Hoppel laid the fewest eggs. This demonstrates that one Indy allele with Hoppel had a strong selective advantage in reproductive fitness, Helfand said.

For life span, flies that had Hoppel on at least one Indy allele lived considerably longer than flies with no Hoppel on either chromosome. For example, among one group of females, by day 60, more than 80 percent of heterozygotes, and about 80 percent with Hoppel on both alleles were still alive. For those without any Hoppel insertion, less than 60 percent were still buzzing about by day 60.

Indy and Hoppel

For all the prior lab work, researchers are still not completely sure how Indy works, with our without mutations such as the Hoppel insertion. The protein the gene encodes appears to help gate metabolically important small nutrients such as citrate in the cell cytoplasm. Mutations in the gene appea
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study finds extreme longevity in white sharks
2. Why cells stick: Phenomenon extends longevity of bonds between cells
3. Dopamine-receptor gene variant linked to human longevity
4. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
5. Personality genes may help account for longevity
6. Horse gaits controlled by genetic mutation spread by humans, new study reveals
7. New hope: Researchers discover genetic mutations that cause rare and deadly lung disease
8. Mutation discovery may improve treatment for rare brain tumor type
9. Important mutation discovered in dairy cattle
10. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
11. Genetic mutation may play key role in risk of lethal prostate cancer in overweight patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Longevity mutation found in flies far and wide
(Date:12/5/2014)...  Tute Genomics, a leader in cloud-based solutions for ... funding led by UK-based Eurovestech. Peak Ventures and a ... round. "We are at a pivotal time ... and seeks new approaches for the diagnosis, treatment and ... MBA, and CEO of Tute Genomics. "One of the ...
(Date:12/3/2014)...   Marvin Test Solutions , a trusted ... military, aerospace, and manufacturing organizations, today announced the ... TS-900 PXI semiconductor test platform . The TS-960 ... to customers at a fraction of the footprint ... "Our semiconductor customers asked for ...
(Date:11/21/2014)... -- According to a new market research ... Access Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), ... Geography - Global Forecasts to 2020", published by MarketsandMarkets, ... around $25 Billion in 2014 and is expected to ... of 8.69%. Browse 116 market data Tables ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... 2013) Monell Center molecular neurobiologist Peihua Jiang, PhD, ... Young Investigators in Gustation, an annual award presented by ... junior scientist who is a rising leader in the ... to the understanding of the structure and function of ...
... to categorize breast cancers into four main groups according ... category a cancer falls into generally determines the best ... one of the four groups called "basal-like" or ... to treat because they usually don,t respond to the ...
... N.C. April 15, 2013 As the world seeks ... energy solutions, UNC Charlotte researcher Deborah Strumsky is leading a ... the array of solar energy technologies that are emerging. ... inter-related factors when building their retirement funds such as ...
Cached Biology News:Peihua Jiang receives Ajinomoto Award for Young Investigators in Gustation from AChemS 2UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment 2UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment 3UNC Charlotte researcher leads effort to forecast optimal energy investments 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... worms. Some species are plant-parasitic and infect plants including ... are withering, seriously retarded growth, and impaired development of ... survive the damage that the worms inflict. Each year, ... agricultural losses worldwide. , Plant roots as food ...
... Organic Chemistry case studies illustrating the value of in situ mid ... , ... Columbia, MD (PRWEB) January 18, 2009 -- ... Advances in Organic Chemistry Using Real-Time In Situ FTIR presented ...
... OmniComm Systems,Inc. (OTC Bulletin Board: OMCM), a leader in ... record breaking results,for 2008 in new and repeat business ... contracts over 2007 clearly validates OmniComm,s,position as a major ... "OmniComm has worked hard to build a strong ...
Cached Biology Technology:Combating infection of crops by nematodes is soon to improve 2OmniComm Systems, Inc. Experiences Record Year End Results - $18 Million in Signed Contracts for the Year 2008 2OmniComm Systems, Inc. Experiences Record Year End Results - $18 Million in Signed Contracts for the Year 2008 3
... Simplify the process and you reduce the ... into the CEQ 8000. Developed using Beckman ... leadership in capillary electrophoresis technology, the CEQ ... system. This system automatically fills the capillary ...
... standard electrophoresis hood is a ... systems. Placed on the transilluminator, ... place and provides a darkroom ... the lab bench. This 13 ...
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
Biology Products: