Navigation Links
Longevity breakthrough: The metabolic state of mitochondria controls life span
Date:12/1/2010

If you think life's too short, then you're not alone. A team of scientists from Texas set out to find what it would take to live a very long life and they made important discoveries that bring longer life spans much closer to reality. A new research report featured on the cover of The FASEB Journal (http://www.fasebj.org), describes how scientists "activated" life extension in the worm, C. elegans, and in the process discovered a new metabolic state correlating with long life.

"C. elegans has provided a useful animal model for human biology," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "because of their relative simplicity and our understanding of the genes that control their metabolism. Helping these worms to live longer is a proof of concept; indeed much of what we now know about human aging was first worked out in these worms."

To make this discovery, scientists compared one class of long-lived C. elegans, called the Mit mutants, with non-mutant wild type C. elegans. Their comparison showed significant metabolism changes, suggesting that their cellular engines had been reconfigured to run on new fuels and to make new waste products, leading to increased lifespans. To determine the cause of these metabolism changes, scientists created a new method for collecting cellular waste and studied it to identify the specific chemical reactions. They found that that the worms achieved long life through changes in how their cells extracted energy (metabolic state). Although C. elegans often is used as an animal model for human biology, more research is needed to determine if an equivalent metabolic state could be created in humans with the same results.

"This research on worms shows that the secret to a long life comes from how we extract energy from our food," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "With any luck, we'll be able to change human life in the same direction: onward and upward!"


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Fountain of youth in bile? Longevity molecule identified
2. Jefferson scientists identify a new protein involved in longevity
3. Tree-dwelling mammals climb to the heights of longevity
4. Longevity tied to genes that preserve tips of chromosomes
5. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
6. Living longer thanks to the longevity gene
7. Breakthrough: With a chaperone, copper breaks through
8. Behavior breakthrough: Like animals, plants demonstrate complex ability to integrate information
9. Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle
10. Study finds low vitamin-d levels in northern California residents with metabolic syndrome
11. AgriLife scientist: Functional amino acids regulate key metabolic pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
(Date:6/23/2016)... Windsor, Connecticut (PRWEB) , ... June 23, 2016 ... ... will introduce a new line of intelligent tools designed, tuned and optimized exclusively ... place September 12–17 in Chicago. The result of a collaboration among several companies ...
Breaking Biology Technology: