Navigation Links
Longevity breakthrough: The metabolic state of mitochondria controls life span
Date:12/1/2010

If you think life's too short, then you're not alone. A team of scientists from Texas set out to find what it would take to live a very long life and they made important discoveries that bring longer life spans much closer to reality. A new research report featured on the cover of The FASEB Journal (http://www.fasebj.org), describes how scientists "activated" life extension in the worm, C. elegans, and in the process discovered a new metabolic state correlating with long life.

"C. elegans has provided a useful animal model for human biology," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "because of their relative simplicity and our understanding of the genes that control their metabolism. Helping these worms to live longer is a proof of concept; indeed much of what we now know about human aging was first worked out in these worms."

To make this discovery, scientists compared one class of long-lived C. elegans, called the Mit mutants, with non-mutant wild type C. elegans. Their comparison showed significant metabolism changes, suggesting that their cellular engines had been reconfigured to run on new fuels and to make new waste products, leading to increased lifespans. To determine the cause of these metabolism changes, scientists created a new method for collecting cellular waste and studied it to identify the specific chemical reactions. They found that that the worms achieved long life through changes in how their cells extracted energy (metabolic state). Although C. elegans often is used as an animal model for human biology, more research is needed to determine if an equivalent metabolic state could be created in humans with the same results.

"This research on worms shows that the secret to a long life comes from how we extract energy from our food," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "With any luck, we'll be able to change human life in the same direction: onward and upward!"


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Fountain of youth in bile? Longevity molecule identified
2. Jefferson scientists identify a new protein involved in longevity
3. Tree-dwelling mammals climb to the heights of longevity
4. Longevity tied to genes that preserve tips of chromosomes
5. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
6. Living longer thanks to the longevity gene
7. Breakthrough: With a chaperone, copper breaks through
8. Behavior breakthrough: Like animals, plants demonstrate complex ability to integrate information
9. Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle
10. Study finds low vitamin-d levels in northern California residents with metabolic syndrome
11. AgriLife scientist: Functional amino acids regulate key metabolic pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
Breaking Biology Technology: