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Longevinex exhibits L-shaped safety curve for first time in resveratrol biology
Date:12/29/2010

Las Vegas, Nevada (Dec. 30, 2010) It was Paracelsus, the Renaissance physician (1493-1541 A.D.) who first said "the dose makes the poison." So, you can drink too much wine, or ingest too much resveratrol, but in an unprecedented study, heart researchers report they couldn't find a toxic dose for Longevinex, a resveratrol-based dietary supplement.

Investigators previously reported that six or more glasses of red wine per day actually increase the risk, whereas 3-5 glasses per day optimally reduce risk for cardiac death. This is the well-known J-shaped risk curve (risk goes down, then up with excessive dose) that has been documented for both red wine and resveratrol.

North Americans who abstain from drinking wine have higher mortality rates for coronary heart disease (~240 per 100,000), making red wine and resveratrol pills tantalizing for those individuals who wish to reduce their risk for a mortal heart attack (~90 per 100,000 for wine drinkers).

The drawback here is that consumption of 3-5 glasses of red wine a day approaches the point of inebriation. Health seekers who wish to avoid the undesirable effects of alcohol may be led to try resveratrol pills, which if taken in mega-doses, could be potentially toxic to the heart.

Unexpected results

In an animal experiment that surprised researchers, circulation was blocked to excised animal hearts and it was unexpectedly found that Longevinex exhibited cardio-protection (minimized damage to heart muscle) over a wide dosage range 100 to 7000 milligrams human equivalent dosage --- whereas 1750 mg of plain resveratrol increases damage to the heart and 3500 milligrams stops ("kills") an excised mouse heart in the laboratory every time. The study is published in a recent issue of Experimental & Clinical Cardiology and is available for viewing online. ( http://
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Contact: Bill Sardi
bsardi@aol.com
909-596-9507
Resveratrol Partners LLC, dba LONGEVINEX
Source:Eurekalert

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