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Longevinex exerts greater influence over genes than resveratrol
Date:12/27/2010

ypoxia inducing factor, or HIF-1 alpha) that adapts malignant cells to a low oxygen environment. MicroRNA 20b also exhibits control over growth factors (such as vascular endothelial growth factor, aka VEGF). The strong silencing (switching off) of HIF-1 alpha via microRNA 20b would be desirable, for example, to inhibit formation of new blood vessels that feed tumors and which invade the retina at the back of the eyes.

Prior to an induced heart attack, microRNA 21 was tremendously up-regulated (up 391.4-fold) by resveratrol and Longevinex (up 760.9-fold), was lowered considerably after a heart attack (-4.0), then returned to up-regulation following a heart attack by resveratrol (up 61.5) and Longevinex (up 59.3), which suggests protective pre-conditioning prior to the event.

MicroRNA 539 exhibited the highest level of up-regulation (214 fold) following a heart attack, which suggests a protective response. Resveratrol diminished this response (down from 214-fold to 172.4 fold) while Longevinex further enhanced this microRNA response, from 214-fold to 314.6-fold increase. MicroRNA 539 controls of a number of genes involved in healing heart tissue following a heart attack.


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Contact: Bill Sardi
bsardi@aol.com
909-596-9507
Resveratrol Partners LLC, dba LONGEVINEX
Source:Eurekalert

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