Navigation Links
Longevinex exerts greater influence over genes than resveratrol
Date:12/27/2010

ching

Of course, the objective is to produce health benefits, not just switch genes. Indeed, these small molecules did just that. Plain resveratrol and Longevinex both protected heart tissues and reduced the size of a heart attack, as measured by the amount of scar tissue (fibrosis).

Longevinex reduced the size of a heart attack (from ~35% without treatment to ~20% scar tissue with treatment) in a superior manner to plain resveratrol (from ~35% to ~24% scar tissue), and reduced death of heart muscle cells (cardiomyocytes) from ~17% without treatment to ~9% with Longevinex (48% reduction in cell death), compared to a decline from ~17% to ~12% with plain resveratrol (20% reduction in cell death).

While plain resveratrol modestly improved the pumping pressure of the heart (from ~75 to ~90 millimeters of mercury pressure; 20% improvement), Longevinex doubled heart pumping pressure (from ~70 to ~140 millimeters of mercury pressure; 100% improvement) compared to no treatment at the two-hour point following an experimentally-induced heart attack.

Also at the two-hour point, Longevinex improved blood flow in the aorta (first blood vessel outside the pumping side of the heart) from ~15 milliliters per minute without treatment to ~26 milliliters per minute (73% improvement), while resveratrol improved blood flow from ~14 milliliters per minute without treatment to ~21 milliliters per minute (50% improvement).

Back to microRNA switching

Upon analysis, it became clear that Longevinex exerted the greatest influence over the top 25 significantly differentiated microRNA's in rodent heart tissue. Longevinex exceeded the effect of resveratrol in 15 of the 25 microRNA's.

Comparative analysis of three key microRNA (microRNA 20b, 21, 539) are instructive.

Longevinex profoundly down-regulated microRNA 20b (-1366-fold) compared to plain resveratrol (-189-fold), a microRNA that exerts control over a gene (h
'/>"/>

Contact: Bill Sardi
bsardi@aol.com
909-596-9507
Resveratrol Partners LLC, dba LONGEVINEX
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Over 1,000 species discovered in the Greater Mekong in past decade
2. Genetic differences between yeasts greater than those between humans and chimpanzees
3. Lower increases in global temps could lead to greater impacts than previously thought, study finds
4. Scots and Irish at greater risk of drink-related death, study shows
5. Food insecurity can lead to greater weight gain and complications during pregnancy
6. Small mammals -- and rest of food chain -- at greater risk from global warming than thought
7. Children born after assisted reproduction at greater risk of congenital malformations
8. Greater food insecurity from recession poses increased risk to low income individuals with diabetes
9. New report suggests why risk for sudden infant death syndrome is greater in babies of mothers who smoke
10. Faster water flow means greater diversity of invertebrate marine life
11. Late-preterm babies at greater risk for problems later in childhood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... hippocampus, the marginal division of the striatum is ... the impact degree of substance P in the ... Yan Yu and his team, College of Biophotonics, ... staining, that substance P receptor, neurokinin 1 was ... division of normal rats. Unilateral or bilateral injection ...
(Date:7/11/2014)... that let nerve cells send out electrical signals, Johns ... tactic that may offer a new way to protect ... responsible way. , Their findingthat naturally occurring insect ... for a closely related onesuggests that insecticides can be ... like bees. A summary of the research, led by ...
(Date:7/10/2014)... 27, 2014  Pomerantz LLP has filed a ... or the "Company")(NYSE-MKT: PVCT) and certain of its ... District Court, Middle District of Tennessee ... a class consisting of all persons or entities ... December 17, 2013 and May 22, 2014, both ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... Ore. The northern spotted owl, a threatened species ... long run from active management of the forest lands ... to stand-replacing fire, researchers conclude in a recent study. ... thinning, or other fuel reduction activities in areas with ...
... gas could become an important source of renewable energy, ... Researchers at both campuses are raising colonies of ... turn electrical energy into pure methane the key ... create large microbial factories that will transform clean electricity ...
... sciences have become especially data-intensive. As researchers rely ... than observations to collect data, discovering, integrating and ... to researchers, ability to address complex questions about ... in it. On March 29, 2012, President ...
Cached Biology News:Active forest management to reduce fire could help protect northern spotted owl 2Stanford-Penn State scientists use microbes to make 'clean' methane 2Stanford-Penn State scientists use microbes to make 'clean' methane 3Stanford-Penn State scientists use microbes to make 'clean' methane 4DataONE answers the call for new tools to study the Earth in this era of Big Data science 2
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its ... TECHNOLOGY: GLOBAL MARKETS , the global market for digital ... in 2013. This is estimated to grow to $490 ... rate (CAGR) of 28.6%. , New digital PCR technology ... within the broader PCR field. The opportunities presented by ...
(Date:7/11/2014)... -- Researchers have pioneered a revolutionary new way to ... Virtual Finger, allows scientists to move through digital ... using the flat surface of their computer screens. ... orders of magnitude more efficient, saving time, money ... areas of experimental biology. The software and its ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Product ... in very low abundance and are often “lost ... and time-consuming. , Join presenters Dr. Rowel Tobias, ... Dr. John Anders, Head of Quality at Nanotherapeutics, ... approach that can speed detection and quantitation while ...
(Date:7/10/2014)... Mass. (PRWEB) July 10, 2014 Terascala, ... today announced that Alan Swahn, a former vice president ... executive team as vice president of marketing. Terascala’s software ... Dell and NetApp create the highest performance and most ... been appointed to guide Terascala’s channel expansion and broaden ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3
... River Systems announces,the successful development and operation of ... the development of its Monarch250(TM) proton,therapy system. This ... that cyclotrons at this high field strength can ... increasing the operating,magnetic field, Still River Systems is ...
... May 21 Prime Therapeutics (Prime), a,thought ... that it has,received accreditation from the National ... Verified Internet Pharmacy Practice,Sites(TM) (VIPPS(R)) Program., ... by NABP in response to,consumers, concerns regarding ...
... Aton Pharma, Inc., a global,specialty pharmaceutical company, ... distribution agreement with PharmaLink Asia Pacific Pte. Ltd.,to ... in Asia and,Australia., "This partnership marks an ... to expand access to our medically essential portfolio ...
Cached Biology Technology:Still River Systems Announces Operation of the World's Highest Magnetic Field Cyclotron 2Prime Therapeutics Receives VIPPS Accreditation 2Aton Pharma Announces Distribution Partnership in the Asia Pacific Region 2
Multidrop Micro high speed 1 l bulk reagent dispenser rapidly, precisely and accurately dispenses microvolumes of 1-50 l into 384- and 96-well microplates....
...
...
Buckets for tube holder inserts...
Biology Products: