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Longevinex exerts greater influence over genes than resveratrol
Date:12/27/2010

Las Vegas, NV (Dec. 24, 2010) - Three weeks of oral resveratrol or Longevinex ingestion prior to an induced heart attack returned microRNA activity close to their pre-event levels in excised animal hearts. Among thousands of microRNA's studied, just six were attributed to exerting the majority of the gene-switching effects measured in the animal heart study four microRNA optimally regulated by Longevinex and two optimally by plain resveratrol.

A pre-conditioning effect with resveratrol and Longevinex had already been demonstrated in prior studies where these small molecules activate antioxidant defenses (nitric oxide, heme oxygenase, adenosine) prior to a heart attack, thus limiting damage in the event of an abrupt halt in the delivery of oxygenated blood to the heart.

This newly published study in the PLoS ONE (Public Library of Science) journal sought to compare and contrast the gene switching pattern for both plain resveratrol and resveratrol in a matrix with other small molecules (Longevinex) following an induced blockage of circulation in excised animal hearts.

MicroRNA explained

MicroRNA is a mechanism within living cells that switches genes. MicroRNA's are short segments of RNA that turn off gene protein-making machinery (called gene expression) when microRNA meshes with messenger RNA.

First thought to exert a minor influence over the human genome (library of genes), microRNA's are now more fully recognized as "the genome's guiding hand" - a fundamental regulator of over 90% of human genes. MicroRNA appear to exert a stronger influence over the human genome than two other known mechanisms (methylation and histone modification) of gene regulation. MicroRNAs exceed the biological action of most drugs, which are largely targeted at single genes, while microRNAs regulate complex networks of genes, there is feverish work being done to create drugs that influence microRNA.

Beyond gene swit
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Contact: Bill Sardi
bsardi@aol.com
909-596-9507
Resveratrol Partners LLC, dba LONGEVINEX
Source:Eurekalert

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