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Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
Date:3/26/2008

k myofiber proteins at a ratio of 590:1 over housekeeper genes

From our observations, we conclude that these (biopsy differences) could only be attributed to marked atrophy caused by a combination of complete diaphragm inactivity and mechanical ventilation, Levine said.

Disuse atrophy of human diaphragm myofibers could be a major contributor to the weaning problems that occur in some of our patients, Levine said. Therefore, we believe fiber atrophy of the magnitude noted in our case diaphragms could have clinical significance.


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Contact: Marc Kaplan
Marc.Kaplan@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
Source:Eurekalert

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