Navigation Links
Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
Date:3/26/2008

PHILADELPHIA A new study by University of Pennsylvania School of Medicine shows, for the first time in humans, that ventilators combined with diaphragm disuse contributes to muscle atrophy in the diaphragm in as little as eighteen hours. Muscle atrophy in the diaphragm is a major contributor of why patients who have undergone prolonged mechanical ventilation often have difficulty breathing after being removed from the ventilator.

The report, published in the March 27th edition of the New England Journal of Medicine, measured a greater than 50 percent decline in muscle fibers in the diaphragm. In addition, the study measured the proteins that play a key role in the muscle-wasting chemical cascade. By intervening in this pathway, the research suggests, a new pharmacological approach to safely and quickly wean patients off ventilators could be developed.

Sanford Levine, PhD, Professor of Thoracic Surgery and co-director of the Respiratory Muscle Research Laboratory, led a team that conducted 22 biopsies on both deceased and living patients. Fourteen brain-dead organ donors, aged 18 to 58, comprised the case study with each having undergone between 18 and 69 hours of mechanical ventilation. The eight-member control group each received less than three hours.

Levine said both groups were demographically and statistically similar except for the time each had spent on mechanical ventilation. Biopsy results on the other hand were different.

Compared to the control group, the diaphragms of the 14 case study members revealed:

  • 23 percent lower levels of the free-radical fighting antioxidant, glutathione

  • 154 percent more Caspase-3, a calcium-dependant executioner enzyme that degrades protein molecules and is responsible for programmed cell deaths

  • Muscle-wasting Atrogin-1 genes at a ratio of 200:1 over MBD4 housekeeper genes that maintain healthy cells

  • MURF-1 nucleotides that attack myofiber proteins at a ratio of 590:1 over housekeeper genes

From our observations, we conclude that these (biopsy differences) could only be attributed to marked atrophy caused by a combination of complete diaphragm inactivity and mechanical ventilation, Levine said.

Disuse atrophy of human diaphragm myofibers could be a major contributor to the weaning problems that occur in some of our patients, Levine said. Therefore, we believe fiber atrophy of the magnitude noted in our case diaphragms could have clinical significance.


'/>"/>

Contact: Marc Kaplan
Marc.Kaplan@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
Source:Eurekalert

Related biology news :

1. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
2. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
3. Tropical crab invades Georgia oyster reefs -- but the long-term impact cant be predicted
4. Meth exposure in young adults leads to long-term behavioral consequences
5. Videos extract mechanical properties of liquid-gel interfaces
6. New mechanical insights into wound healing and scar tissue formation
7. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
8. 4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats
9. KGI professor contributes new insights on jumping genes
10. Scientists launch first comprehensive database of human oral microbiome
11. Scientists launch human oral microbiome database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Rotary Club. The event entitled “Stem Cells and Their Regenerative Powers,” ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, ...
Breaking Biology Technology: