Navigation Links
Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
Date:3/26/2008

PHILADELPHIA A new study by University of Pennsylvania School of Medicine shows, for the first time in humans, that ventilators combined with diaphragm disuse contributes to muscle atrophy in the diaphragm in as little as eighteen hours. Muscle atrophy in the diaphragm is a major contributor of why patients who have undergone prolonged mechanical ventilation often have difficulty breathing after being removed from the ventilator.

The report, published in the March 27th edition of the New England Journal of Medicine, measured a greater than 50 percent decline in muscle fibers in the diaphragm. In addition, the study measured the proteins that play a key role in the muscle-wasting chemical cascade. By intervening in this pathway, the research suggests, a new pharmacological approach to safely and quickly wean patients off ventilators could be developed.

Sanford Levine, PhD, Professor of Thoracic Surgery and co-director of the Respiratory Muscle Research Laboratory, led a team that conducted 22 biopsies on both deceased and living patients. Fourteen brain-dead organ donors, aged 18 to 58, comprised the case study with each having undergone between 18 and 69 hours of mechanical ventilation. The eight-member control group each received less than three hours.

Levine said both groups were demographically and statistically similar except for the time each had spent on mechanical ventilation. Biopsy results on the other hand were different.

Compared to the control group, the diaphragms of the 14 case study members revealed:

  • 23 percent lower levels of the free-radical fighting antioxidant, glutathione

  • 154 percent more Caspase-3, a calcium-dependant executioner enzyme that degrades protein molecules and is responsible for programmed cell deaths

  • Muscle-wasting Atrogin-1 genes at a ratio of 200:1 over MBD4 housekeeper genes that maintain healthy cells

  • MURF-1 nucleotides that attack myofiber proteins at a ratio of 590:1 over housekeeper genes

From our observations, we conclude that these (biopsy differences) could only be attributed to marked atrophy caused by a combination of complete diaphragm inactivity and mechanical ventilation, Levine said.

Disuse atrophy of human diaphragm myofibers could be a major contributor to the weaning problems that occur in some of our patients, Levine said. Therefore, we believe fiber atrophy of the magnitude noted in our case diaphragms could have clinical significance.


'/>"/>

Contact: Marc Kaplan
Marc.Kaplan@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
Source:Eurekalert

Related biology news :

1. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
2. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
3. Tropical crab invades Georgia oyster reefs -- but the long-term impact cant be predicted
4. Meth exposure in young adults leads to long-term behavioral consequences
5. Videos extract mechanical properties of liquid-gel interfaces
6. New mechanical insights into wound healing and scar tissue formation
7. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
8. 4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats
9. KGI professor contributes new insights on jumping genes
10. Scientists launch first comprehensive database of human oral microbiome
11. Scientists launch human oral microbiome database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
(Date:1/28/2016)... 28, 2016 Synaptics (NASDAQ: SYNA ), a leading ... second quarter ended December 31, 2015. --> ... fiscal 2016 increased 2 percent compared to the comparable quarter last ... fiscal 2016 was $35.0 million, or $0.93 per diluted share. ... for the first quarter of fiscal 2016 grew 9 percent over ...
(Date:1/25/2016)... --  Unisys Corporation (NYSE: UIS ) today announced the ... Airport, New York City , to help ... enter the United States using passports that ... testing of the system at Dulles last year. The system ... January 2016. --> pilot testing of the system ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... 2016 , ... Global Stem Cells Group, has ... The new facility will provide advanced protocols and state-of-the-art techniques in cellular medicine, ... , The new GSCG clinic is headed by four prominent Ecuadorian physicians, including ...
(Date:2/10/2016)... WASHINGTON , February 10, 2016 Early-career ... , Peru , Uganda ... their life-enhancing work in health and nutrition   Indonesia ... Uganda and Yemen are ... sciences and epidemiology. They are also celebrated for mentoring young women scientists ...
(Date:2/10/2016)... LOUISVILLE, Ky. , Feb. 10, 2016 ... company utilizing its proprietary NeXosome® technology for early ... presentation of its most recent study by Dr. ... Hospital at the Society for Maternal Fetal Medicine,s (SMFM) ... , GA, February 1-6 th , 2016.  The presentation ...
(Date:2/10/2016)... , ... February 10, 2016 ... ... today announced that it has joined the Human Vaccines Project, a public-private ... diseases and cancer. , The Human Vaccines Project brings together leading ...
Breaking Biology Technology: