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Long-term study of middle-aged mice shows
Date:7/3/2008

ardiovascular health. Their arteries were more youthful, and they had reduced aortic stiffness. They also had fewer free radicals and DNA damage.

"Frailty in humans is an important health concern," says Christoph Westphal, M.D., Ph.D., Chief Executive Officer, Sirtris, a GSK Company. "This study informs us how frailty in mice can be delayed, and this knowledge could help us translate preclinical benefits to humans. We are in clinical trials with SRT501, our proprietary formulation of resveratrol that has shown efficacy signs in humans in Phase 1b testing, and we are also testing a novel SIRT1 activator in a human clinical trial."


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Contact: John Lacey
jlacey@sirtrispharma.com
617-252-6920
Pure Communications Inc.
Source:Eurekalert

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