Navigation Links
Long-term study of middle-aged mice shows
Date:7/3/2008

CAMBRIDGE, Mass., July 3, 2008 -- Sirtris, a GlaxoSmithKline company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, is included among a research team that reported in today's online edition of Cell Metabolism that mice treated at middle-age to the end-of-life with resveratrol showed an overall health improvement, including improved bone health, a reduction in cataracts and cardiovascular dysfunction, and improved balance and motor coordination.

"In this study, we wanted to determine whether or not resveratrol, which imparts many of the same health benefits as caloric restriction in mice, does so by inducing a physiology similar to dietary restriction," says study co-author David Sinclair, Ph.D., a Sirtris co-founder and Harvard Medical School Associate Professor of Pathology. "The data show that resveratrol does induce many similar pathways," says Sinclair, who is co-chair of Sirtris' Scientific Advisory Board. The study was co-led by Rafael de Cabo, Ph.D. at the National Institute on Aging and David Sinclair.

The research team began testing of mice at one year, the mouse equivalent of middle-age, as that is when a small molecule drug mimicking dietary restriction might be given to humans.

The mice were placed on different diets: a standard diet (SD); every-other-day feeding (EOD); and a high-calorie diet (HC). Mice in each dietary regime were divided into treated and untreated subgroups, with some not receiving resveratrol and others receiving different dosage levels of resveratrol.

The study showed that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by dietary restriction, a diet known to slow aging and extend lifespan in rodents and dogs. The study also found a significant increase in lifespan in both the resveratrol treated group on a high-calorie diet and the resveratrol treated group on a calorie re
'/>"/>

Contact: John Lacey
jlacey@sirtrispharma.com
617-252-6920
Pure Communications Inc.
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Meth exposure in young adults leads to long-term behavioral consequences
2. Tropical crab invades Georgia oyster reefs -- but the long-term impact cant be predicted
3. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
4. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
5. Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
6. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
7. Forests long-term potential for carbon offsetting
8. New vaccine may give long-term defense against deadly bird flu and its variant forms
9. Cancer immunotherapy shows long-term promise in lung cancer
10. Study of marine snail leads to new insights into long-term memory
11. Dont count on long-term success in climate policy, warns paper in Decision Analysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2015)... , March 17, 2015 Emotient, ... analytics software, today announced general availability of ... service for the analysis of facial expressions. The ... advertising, media content, products and services. It delivers ... engagement and sentiment - as derived from facial ...
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/12/2015)... -- The mascots of the Atlantic Coast Conference spent ... Forest Baptist Medical Center. They stopped by as part ... Basketball Tournament. Young patients enjoyed bonding with their favorite ... Brenner Children,s Hospital is the pediatric arm ... hospital in northwest North Carolina ...
Breaking Biology News(10 mins):New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
... (PINK SHEETS: DLSC) announces the appointment of Randall ... McCormick replaces outgoing President Mr. Berge Heede who resigned for personal ... "resigning for personal reasons and to allow Mr. McCormick to take ... the current Treasurer, will maintain that responsibility as well. , ...
... Legal loopholes and insufficient law enforcement mean that ... market in Asia, says a new report from ... report also raises concerns that legal provisions governing ... illegal trade in wild-caught, highly-endangered Asian elephants from ...
... It,s common knowledge that a protective navy of ... least temporarily disturb the normal balance. But it,s unclear ... full array of "good bacteria" return promptly or remain ... mice, University of Michigan scientists have shown for the ...
Cached Biology News:delSECUR CORPORATION Announces Appointment of the Company's President & CEO 2Elephant-size loopholes sustain Thai ivory trade 2Antibiotics take toll on beneficial microbes in gut 2Antibiotics take toll on beneficial microbes in gut 3
(Date:3/26/2015)... WriteResult, a premier provider of ePRO technologies and ... of Public Health and New Haven Farms to capture ... project. The goal of the study was to evaluate ... access to fresh produce and nutrition education on food ... blood pressure, diabetes and weight gain. Patients completed an ...
(Date:3/25/2015)... 2015 The surging prevalence of ... fuelled social media growth, with over 50% of ... social networking. Insurance companies are making use of ... and promote a diversity of their services and ... exploiting social networking services as part of sales ...
(Date:3/25/2015)... London, UK (PRWEB) March 25, 2015 ... of natural ingredients in all forms of food nutrients, ... led to a substantial rise in demand for natural ... astaxanthin have started to ramp up their capacities to ... for both natural and synthetic source astaxanthin (used in ...
(Date:3/25/2015)... ST LOUIS and the HAGUE, ... publication of two-year results of LES Stimulation therapy for ... of the journal Surgery [ Surgery ... and efficacy of its minimally-invasive therapy. ... an average duration of 11 years and taking prescribed ...
Breaking Biology Technology:Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3
... With dimensions measuring billionths of a meter, nanoparticles are way ... is becoming possible for today,s scientists not only to see ... are arranged in three dimensions using a technique called nanocrystallography. ... as x-ray synchrotrons, are only available at a handful of ...
... 4, 2012  Andrew Technologies, LLC launched the HydraSolve™ ... Aesthetic Plastic Surgery (ASAPS) in Vancouver, BC. ASAPS ... surgeons focused on aesthetic body contouring and is ... (Photo: http://photos.prnewswire.com/prnh/20120504/NY98979 ) ...
...  The San Diego Chapter of the National Investor Relations ... Tips & Tactics for Establishing & Maintaining a Successful ... 2012 meeting. The panel of seasoned IR ... and share their unique perspectives on what makes an ...
Cached Biology Technology:New technique uses electrons to map nanoparticle atomic structures 2New technique uses electrons to map nanoparticle atomic structures 3New HydraSolve™ Lipoplasty System launched at American Society of Aesthetic Plastic Surgery Meeting 2New HydraSolve™ Lipoplasty System launched at American Society of Aesthetic Plastic Surgery Meeting 3New HydraSolve™ Lipoplasty System launched at American Society of Aesthetic Plastic Surgery Meeting 4NIRI San Diego May Meeting: Seasoned IROs Discuss "Tips & Tactics for Establishing and Maintaining A Successful Investor Relations Program" 2NIRI San Diego May Meeting: Seasoned IROs Discuss "Tips & Tactics for Establishing and Maintaining A Successful Investor Relations Program" 3
... Clear yellow solution. ... 0.01% thimerosal, and other ... filtered. Diluent formulated to ... peroxidase antibody conjugates at ...
... WinMelt software is used ... of any DNA sequence up ... in optimizing placement of primers ... detection by denaturing gradient gel ...
... and PowerPac basic power supply are used for ... agarose gels. The Mini-Sub cell GT cell includes ... a 7 x 7 cm UV-transparent gel tray ... 1.5 mm fixed-height combs (8- and 15-well). The ...
... cell and PowerPac basic power supply are used ... in agarose gels. The mini format cell includes ... and leveling bubble. The PowerPac basic power supply, ... V, 4-400 mA, and 75 W. Power cord ...
Biology Products: