Navigation Links
Long noncoding RNAs control development of fat cells
Date:2/13/2013

ods that have yet to be elucidated. Recently, the Lodish lab identified lncRNAs as playing a vital role in regulating programmed cell death during one of the final stages of red blood cell differentiation.

To determine the function of the identified active lncRNAs in fat cells, Lei Sun, a former postdoctoral researcher in the Lodish lab, and Loyal Goff from Harvard University and the Broad Institute, knocked each lncRNA down individually in fat precursor cells and analyzed the results. When 10 of these lncRNAs had reduced expression, the cells did not turn on the genes that are usually expressed in mature white fat cells, and the cells had significantly smaller lipid droplets than white fat cells with normal lncRNA expression. Their work is reported in this week's issue of the Proceedings of the National Academy of Sciences (PNAS).

"This is the first study showing the importance of lncRNAs for the regulation of adipogeneis," says Sun, who is now an assistant professor at Duke-NUS Graduate Medical School. "Our understanding of lncRNA function in these cells is still incomplete, but in the future, this line of research may reveal new pathways that obesity drugs could target."


'/>"/>

Contact: Nicole Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Advance promises to expand biological control of crop pests
2. Nature Methods study: Using light to control cell clustering
3. Biocontrol research on Brazilian peppertree in Florida discovers new cryptic species
4. Female deer take control during the mating season
5. Dartmouth research offers new control strategies for bipolar bark beetles
6. Chance finding reveals new control on blood vessels in developing brain
7. Scientists discover structure of protein essential for quality control, nerve function
8. Liver controls wasting in cancer
9. Lady beetle diet influences its effectiveness as biocontrol agent
10. New study identifies significance of co-infection in disease control
11. Cruise Control sets runners on right note
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... cutting-edge, innovative research on Alzheimer,s disease and the ... announced the recipients of new research grant awards, ... the District of Columbia, and five foreign countries. ... latest grants, BrightFocus has now provided more than ... The research projects funded this year reflect a ...
(Date:7/10/2014)... strong currents in the Straits of Mackinac reverse direction ... beneath the channel would quickly contaminate shorelines miles away ... new University of Michigan study commissioned by the National ... study and accompanying animations, oil from a hypothetical pipeline ... hours and Bois Blanc Island after two days. All ...
(Date:7/10/2014)... (July 10, 2014) Columbia University Medical Center (CUMC) ... therapies for patients with retinitis pigmentosa (RP), a leading ... its kind, takes advantage of induced pluripotent stem (iPS) ... which are then used as a patient-specific model for ... researchers led by Stephen H. Tsang, MD, PhD, showed ...
Breaking Biology News(10 mins):BrightFocus Foundation announces 55 new grantees in Alzheimer's and vision research 2BrightFocus Foundation announces 55 new grantees in Alzheimer's and vision research 3Straits of Mackinac 'worst possible place' for a Great Lakes oil spill 2Straits of Mackinac 'worst possible place' for a Great Lakes oil spill 3Patient-specific stem cells and personalized gene therapy 2Patient-specific stem cells and personalized gene therapy 3
... simple technique to make a common virus-killing material significantly more ... Andrew Barron and Qilin Li. Rather than trying to ... into the public domain. They hope wide adoption will save ... professors and their team reported in Environmental Science and ...
... ITHACA, N.Y. Scientists have identified the genes related ... for planting crops closer together, which has led to an ... Genetics , Jan. 9, 2011.) The study, led ... Agricultural Research Service (USDA-ARS) at Cornell and North Carolina ...
... MD (January 11, 2011)-- The Genetics Society of America ... Research Conference, March 30-April 3, 2011 at the Town ... This annual meeting brings together basic research scientists, ... the common fruit fly, whose hereditary traits Thomas Hunt ...
Cached Biology News:Virus killer gets supercharged 2Virus killer gets supercharged 3Technique allows researchers to identify key maize genes for increased yield 252nd Genetics Society of America Drosophila Research Conference announced 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... 15 NeoStem, Inc. (NYSE Amex: NBS ), which ... stem cells for future medical need, was featured on CBS2 News, ... and Tuesday morning July 14, 2009. , , ... of Dr. Christopher Centeno, a NeoStem consultant in stem cell therapies ...
... EXTON, Pa., July 15 Morphotek((R)), Inc., a subsidiary ... (CII), a privately held biotechnology company specializing in the development ... an evaluation and option agreement in which Morphotek will evaluate ... , The agreement with CII provides ...
... ... organizations was a key factor in the recent decision by the University of Florida Shands ... informatics needs. With the signing of the contract, the UFSCC has become the 25th ... ...
Cached Biology Technology:NeoStem Featured on CBS2 News; Success of Licensed Stem Cell Treatments Shown for Arthritis and Orthopedic Problems; Procedure to be Used by NeoStem Affiliate in China 2NeoStem Featured on CBS2 News; Success of Licensed Stem Cell Treatments Shown for Arthritis and Orthopedic Problems; Procedure to be Used by NeoStem Affiliate in China 3NeoStem Featured on CBS2 News; Success of Licensed Stem Cell Treatments Shown for Arthritis and Orthopedic Problems; Procedure to be Used by NeoStem Affiliate in China 4Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies 2Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies 3University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 2University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 3University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 4University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 5
BD Falcon, microtest ELISA plate 96 well flat-bottom, clear. Polystyrene, nonsterile, no lid (25/sp, 100/ca) Packaging: 25 / pack, 100 / case ...
... The Chemicon Detergent-OUT Kit is a ... from protein solutions. Removes detergents without ... load the protein solution on the Detergent-OUT ... solution. Micro columns are suitable for removing ...
... is a simple high performance method for ... detergents without significant dilution of protein solution. ... the Detergent-OUT Spin column and collect detergent ... suitable for removing detergent from a maximum ...
... microarrays are derived from frozen embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... slides. Sections are large (3-5 mm in ...
Biology Products: