Navigation Links
Long-lasting nerve block could change pain management
Date:4/15/2009

Researchers at Children's Hospital Boston have developed a slow-release anesthetic drug-delivery system that could potentially revolutionize treatment of pain during and after surgery, and may also have a large impact on chronic pain management. In NIH-funded work, they used specially designed fat-based particles called liposomes to package saxitoxin, a potent anesthetic, and produced long-lasting local anesthesia in rats without apparent toxicity to nerve or muscle cells. The research was published online April 13 by the Proceedings of the National Academy of Sciences.

"The idea was to have a single injection that could produce a nerve block lasting days, weeks, maybe even months," explains Daniel Kohane, MD, PhD, of the Division of Critical Care Medicine in the Department of Anesthesiology at Children's, and the report's senior author. "It would be useful for conditions like chronic pain where, rather than use narcotics, which are systemic and pose a risk of addiction, you could just put that piece of the body to sleep, so to speak."

Previous attempts to develop slow-release anesthetics have not been successful due to the tendency for conventional anesthetics to cause toxicity to surrounding tissue. Indeed, drug packaging materials have themselves been shown to cause tissue damage. Now, Kohane and colleagues report that if saxitoxin is packaged within liposomes, it is able to block nerve transmission of pain without causing significant nerve or muscle damage.

In lab experiments, the researchers evaluated various formulations -- various types of liposomes containing saxitoxin with or without dexamethasone, a potent steroid known to augment the action of encapsulated anesthetics. The best liposomes produced nerve blocks lasting two days if they contained saxitoxin alone and seven days if combined with dexamethasone.

Cell culture experiments and tissue analysis confirmed that the formulations were not toxic to musc
'/>"/>

Contact: Rob Graham
rob.graham@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Carbon monoxide may cause long-lasting heart damage
2. Specific brain protein required for nerve cell connections to form and function
3. Targeting nerve growth factor may cure liver cancer
4. West Nile virus spread through nerve cells linked to serious complication
5. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
6. Salk scientists identify key nerve navigation pathway
7. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
8. Engineer develops detergent to promote peripheral nerve healing
9. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
10. Compound that helps rice grow reduces nerve, vascular damage from diabetes
11. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Long-lasting nerve block could change pain management
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
(Date:10/16/2014)... 2014) – Post-menopausal women experienced improvements in vaginal ... or genital bleeding, after 12 weeks of daily ... soy germ-based nutritional supplement previously shown to help ... peer-reviewed pilot study reported in a poster at ... meeting. , "These data documented improved vaginal ...
(Date:10/15/2014)... assess the pandemic risk from strains of influenza virus ... allow ourselves to become complacent that the most substantial ... scientists. , Influenza pandemics arise when a new virus ... widespread immunity – spreads in the human population. There ... years, the worst of which – the 1918 Spanish ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... have developed a breed of American chestnut that is resistant ... early 1900s. But the return of this "king of ... more than 100 feet, remains hampered by a slew of ... the verge of overcoming chestnut blight, but there is a ...
... susceptible to air pollution (which can lead to increased ... locations in their everyday lives that contain high levels ... team led by the University of Cincinnati and funded ... Sang Young Son, assistant professor in the University of ...
... MA (09/05/07)--It is well established that a child,s brain ... about the extent to which such plasticity exists in ... MIT and Johns Hopkins University have used converging evidence ... the adult visual cortex does indeed reorganize-and that the ...
Cached Biology News:Challenges remain in reintroducing American chestnut 2Challenges remain in reintroducing American chestnut 3UC's NIH grant brings technology from outer space to playgrounds 2UC's NIH grant brings technology from outer space to playgrounds 3Adult brain can change, study confirms 2
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. ... approximately 400 million people worldwide are living with diabetes, ... people by 2030.  The global market for diabetes treatments ... approximately 330,000 people worldwide died from pancreatic cancer.  Pancreatic ... due to cancer in the United States ...
(Date:10/20/2014)... 20, 2014 Mapp Biopharmaceutical,s valiant effort ... therapeutic to fight the Ebola outbreak will make ... the production of pharmaceuticals can be, according to ... that while some may be taken aback by ... with industry knowledge are well aware of the ...
(Date:10/20/2014)... , October 20, 2014 ... gastrointestinal (GI) disorders and the delivery of care has ... diseases and worrying inequalities in the provision of healthcare ... which was commissioned by United European Gastroenterology (UEG), have ... political and public awareness of the burden of GI ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Partners LLC, announced today that Ellen Teplitzky, an ... support for the pharmaceutical industry, has joined the ... of its legal services practice. NDA Partners ... expert witness and testimony, to top law firms ...
Breaking Biology Technology:Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... Technology to Optimize Efficiency and ... Safety and Reduce Cost of Ownership, ST. ... a member of the Sigma-Aldrich Group (Nasdaq: SIAL ),today ... for compound semiconductor manufacturing.,EpiVapor eliminates the need for localized tool ...
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ONCY) ... study of,intravenous REOLYSIN(R) in patients with sarcomas metastatic ... Society of Clinical Oncology,(ASCO) annual meeting. The presentation, ... Reovirus) in the Treatment of Patients with,Bone and ...
... transaction expertise, SAN DIEGO, June 2 ... Truex to its Board of Directors. Truex is,the ... he,served as President and CEO of Peninsula Pharmaceuticals ... (including $21000000 from a key,strategic partner) and negotiated ...
Cached Biology Technology:SAFC Hitech Launches Metalorganic Bulk Vapor Distribution System for Compound Semiconductor Manufacturing 2SAFC Hitech Launches Metalorganic Bulk Vapor Distribution System for Compound Semiconductor Manufacturing 3SAFC Hitech Launches Metalorganic Bulk Vapor Distribution System for Compound Semiconductor Manufacturing 4Oncolytics Biotech Inc. Collaborators Present Positive Phase II Sarcoma Trial Results at ASCO Annual Meeting 2Trius Appoints Paul Truex to Board of Directors 2