Navigation Links
Long-lasting nerve block could change pain management
Date:4/15/2009

Researchers at Children's Hospital Boston have developed a slow-release anesthetic drug-delivery system that could potentially revolutionize treatment of pain during and after surgery, and may also have a large impact on chronic pain management. In NIH-funded work, they used specially designed fat-based particles called liposomes to package saxitoxin, a potent anesthetic, and produced long-lasting local anesthesia in rats without apparent toxicity to nerve or muscle cells. The research was published online April 13 by the Proceedings of the National Academy of Sciences.

"The idea was to have a single injection that could produce a nerve block lasting days, weeks, maybe even months," explains Daniel Kohane, MD, PhD, of the Division of Critical Care Medicine in the Department of Anesthesiology at Children's, and the report's senior author. "It would be useful for conditions like chronic pain where, rather than use narcotics, which are systemic and pose a risk of addiction, you could just put that piece of the body to sleep, so to speak."

Previous attempts to develop slow-release anesthetics have not been successful due to the tendency for conventional anesthetics to cause toxicity to surrounding tissue. Indeed, drug packaging materials have themselves been shown to cause tissue damage. Now, Kohane and colleagues report that if saxitoxin is packaged within liposomes, it is able to block nerve transmission of pain without causing significant nerve or muscle damage.

In lab experiments, the researchers evaluated various formulations -- various types of liposomes containing saxitoxin with or without dexamethasone, a potent steroid known to augment the action of encapsulated anesthetics. The best liposomes produced nerve blocks lasting two days if they contained saxitoxin alone and seven days if combined with dexamethasone.

Cell culture experiments and tissue analysis confirmed that the formulations were not toxic to musc
'/>"/>

Contact: Rob Graham
rob.graham@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Carbon monoxide may cause long-lasting heart damage
2. Specific brain protein required for nerve cell connections to form and function
3. Targeting nerve growth factor may cure liver cancer
4. West Nile virus spread through nerve cells linked to serious complication
5. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
6. Salk scientists identify key nerve navigation pathway
7. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
8. Engineer develops detergent to promote peripheral nerve healing
9. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
10. Compound that helps rice grow reduces nerve, vascular damage from diabetes
11. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Long-lasting nerve block could change pain management
(Date:1/22/2015)... Fla. , Jan. 13, 2015  Today, FreeWavz ... technology, launched its crowdfunding campaign on Fundable, ... the build of production capacity to meet customer ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... 15, 2015  BellBrook Labs, a leader in high ... launch of a TR-FRET (time resolved Forster resonance ... Assay, a high throughput screening assay for glycosyltransferases ... allow for sensitive detection of hundreds of human ...
(Date:1/22/2015)... (NASDAQ: NXTD and NXTDW) a biometric authentication company focused ... the Wocket™ smart wallet at CES 2015 in Las Vegas ... of the "11 Hot Products at CES" in a review published in ... by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... ability of Australian desert birds to adapt to cycles ... a new book launched today by CSIRO Publishing at ... and Bust: Bird stories for a dry country sheds ... ecological change. Studies of key bird species, such ...
... advantage in the media. A new study by Dr. ... the journal of Israel,s National Security College, describes how ... too. "Information warfare" plays a crucial ... so than conventional weapons. Therefore, the information warfare against ...
... the natural glue that marine mussels use to stick to ... of researchers led by North Carolina State University has devised ... traditional sutures and result in less scarring, faster recovery times ... Traditionally, there have been two ways to join tissue ...
Cached Biology News:Fly like a bird through boom and bust 2Information warfare in the 21st century: Ideas are sometimes stronger than bombs 2Shellfish and inkjet printers may hold key to faster healing from surgeries 2
(Date:2/27/2015)... 2015  Pharmacyclics, Inc. (NASDAQ: PCYC ... its newly developed Bruton,s tyrosine kinase (BTK) inhibitor ... The results of these preclinical evaluations have been ... The feedback received from the Agency is supportive ... Additional preclinical work is required to begin a ...
(Date:2/27/2015)... Feb. 27, 2015 Research and Markets ( ... Market Report of Trypsin" report to their offering. ... aims at providing comprehensive data on Trypsin globally and regionally ... North America , Latin America ... attention to Trypsin This report focuses on three ...
(Date:2/27/2015)... 2015 The fully automated supercritical ... can sequentially analyze up to 48 samples utilizing ... detection of targets by mass spectrometry. , ... the measurement requirements of a wide range of ... delivery and search for disease biomarkers, additives in ...
(Date:2/27/2015)... DIEGO , Feb. 27, 2015  Pfenex Inc. ... the development of biosimilar therapeutics, today announced that it ... Francisco Marriott Marquis on March 2 nd at ... participate on a panel discussing the current state of ... of Biosimilars . For more information ...
Breaking Biology Technology:Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3Global Market Report of Trypsin 2014-2018 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3
... GRINSTEAD, West Sussex, U.K. and CLEVELAND, Nov. 18 ... and premier provider of diagnostic systems and susceptibility ... Grinstead, U.K., manufacturing and research and development facility ... product line for susceptibility and identification testing. The ...
... ... characterizing DNA-protein interactions. , ... Madison, WI, USA (PRWEB) November 18, 2009 -- Promega Corporation ... a study using the HaloCHIP™ System and high-throughput promoter assays demonstrate the ability ...
... , , MONROVIA, Calif. ... Corp . ("Niusule" or the "Company") (OTC Bulletin Board: ... selling nutritional products for children, today announced that the Company,s ... largest city in China. The Company has entered into a ...
Cached Biology Technology:TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 2TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 3TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 4Promega and SwitchGear Publish Findings from Combined Technologies that Correlate Binding Events and Transcriptional Activity 2Niusule Expands Geographic Footprint in China 2Niusule Expands Geographic Footprint in China 3
... Protein Phosphatase-2A (PPase-2A) is a serine/threonine ... It is isolated as the heterodimer of ... has the ability to dephosphorylate the a-subunit ... subunit, PPase-2A has broad substrate specificity and ...
... is a high performance spectral scanning ... incubator. With the advanced SkanIt Software ... for drug discovery assay development. Varioskan ... intensity, time-resolved fluorescence and photometric assays ...
... wide variety of solvent vapors that can contaminate and ... allows for the collection of liquid into a self ... waiting period., Ultra low -104 o C ... , Digital Display of temperature ...
Immulon 2HB, Flat Bottom, 50/Bx; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes....
Biology Products: