Navigation Links
'Lonely' bacteria increase risk of antibiotic resistance
Date:4/29/2014

Scientists from The University of Manchester have discovered that 'lonely' microbes are more likely to mutate, resulting in higher rates of antibiotic resistance.

The study, published today in Nature Communications and jointly funded by The Wellcome Trust and Engineering and Physical Sciences Research Council, explored the mutation rates of E. coli.

Researchers found out that the rate of mutation varied according to how many of the bacteria there were. Surprisingly, they discovered that more bacteria gave fewer mutations.

Meanwhile more 'lonely' bacteria developed greater resistance to the well-known antibiotic Rifampicin, used to treat tuberculosis.

Dr Chris Knight joint lead author on the study with Dr. Rok Kraovec from The University of Manchester, said: "What we were looking for was a connection between the environment and the ability of bacteria to develop the resistance to antibiotics. We discovered that the rate at which E. coli mutates depends upon how many 'friends' it has around. It seems that more lonely organisms are more likely to mutate."

This change of the mutation rate is controlled by a form of social communication known as quorum sensing this is the way bacteria communicate to let each other know how much of a crowd there is. This involves the release of signalling molecules by bacteria when in a dense population to help the organisms understand their surrounding environment and coordinate behaviour to improve their defence mechanisms and adapt to the availability of nutrients.

Dr. Kraovec said: "We were able to change their mutation rates by changing who they shared a test tube with, which could mean that bacteria manipulate each other's mutation rates. It also suggests that mutation rates could be affected when bacteria are put at low densities for instance by a person taking antibiotics."

The rate of mutation was found to be dependent on the gene luxS which is known to be involved in quorum sensing in a wide range of bacteria.

The team now hopes to find ways to control this signalling for medical applications in a future study funded by the Biotechnology and Biological Sciences Research Council.

"Eventually this might lead to interventions to control mutation rates, for instance to minimise the evolution of antibiotic resistance, allowing antibiotics to work better," said Dr Knight.

Dr Mike Turner, Head of Infection and Immunobiology at the Wellcome Trust said: "Antibiotic resistance is a real threat to disease control and public health today. Any insight into the origins of such resistance is valuable in the fight to prevent it. Chris Knight and his team have gained a fundamental understanding of bacterial communication and the development of mutations which in the long run could contribute to more potent antibiotics and better control of bacterial disease".


'/>"/>
Contact: Meera Senthilingam
m.senthilingam@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Related biology news :

1. Plants send out signals attracting harmful bacteria, MU study finds
2. How a plant beckons the bacteria that will do it harm
3. Theoretical biophysics: Adventurous bacteria
4. Gate for bacterial toxins found
5. Antimicrobial from soaps promotes bacteria buildup in human noses
6. Bacterial gut biome may guide colon cancer progression
7. Immune cell defenders could beat invading bacteria
8. Engineered bacteria produce biofuel alternative for high-energy rocket fuel
9. Among US children, more infections caused by drug-resistant bacteria
10. Gut bacteria can cause life-threatening infections in preterm babies
11. Bacterial reporters that get the scoop
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For the second ... a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, ... from US2020. , US2020’s mission is to change the trajectory of STEM education ...
(Date:10/10/2017)... ... 10, 2017 , ... The Pittcon Program Committee is pleased ... scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each ... leading conference and exposition for laboratory science, which will be held February 26-March ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the ... in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective ...
(Date:10/6/2017)... (PRWEB) , ... October 06, 2017 , ... ... host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial ... Investigator, Dana-Farber Cancer Institute. The event is free and open to the public, ...
Breaking Biology Technology: