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'Lonely' bacteria increase risk of antibiotic resistance
Date:4/29/2014

Scientists from The University of Manchester have discovered that 'lonely' microbes are more likely to mutate, resulting in higher rates of antibiotic resistance.

The study, published today in Nature Communications and jointly funded by The Wellcome Trust and Engineering and Physical Sciences Research Council, explored the mutation rates of E. coli.

Researchers found out that the rate of mutation varied according to how many of the bacteria there were. Surprisingly, they discovered that more bacteria gave fewer mutations.

Meanwhile more 'lonely' bacteria developed greater resistance to the well-known antibiotic Rifampicin, used to treat tuberculosis.

Dr Chris Knight joint lead author on the study with Dr. Rok Kraovec from The University of Manchester, said: "What we were looking for was a connection between the environment and the ability of bacteria to develop the resistance to antibiotics. We discovered that the rate at which E. coli mutates depends upon how many 'friends' it has around. It seems that more lonely organisms are more likely to mutate."

This change of the mutation rate is controlled by a form of social communication known as quorum sensing this is the way bacteria communicate to let each other know how much of a crowd there is. This involves the release of signalling molecules by bacteria when in a dense population to help the organisms understand their surrounding environment and coordinate behaviour to improve their defence mechanisms and adapt to the availability of nutrients.

Dr. Kraovec said: "We were able to change their mutation rates by changing who they shared a test tube with, which could mean that bacteria manipulate each other's mutation rates. It also suggests that mutation rates could be affected when bacteria are put at low densities for instance by a person taking antibiotics."

The rate of mutation was found to be dependent on the gene l
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Contact: Meera Senthilingam
m.senthilingam@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

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