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Lombardi scientist brings 'dream team' breast cancer research effort to GUMC
Date:5/27/2009

ch year. While called breast cancer, tumors that develop in the breast can have many different characteristics and require tailored treatment based on these characteristics. Still, many cancers don't respond to treatment, grow resistant to therapy or can recur. Understanding the molecular diversity of human breast cancer has been a driving force in leading to a new and exciting era in cancer treatment. This understanding has already led to more effective and less toxic treatments.

Jordan is an internationally recognized breast cancer scientist whose research focuses on the response of breast cancer cells to preventive and treatment agents. He is recognized by many as the "father" the anti-cancer drug tamoxifen, a drug that blocks estrogen from fueling some breast cancers. Millions of women around the world continue to be treated with tamoxifen. Jordan's team, led by Dennis Slamon, MD, PhD, University of California, Los Angeles and Joe Gray, PhD, Lawrence Berkley National Laboratory, is focused on understanding the molecular subtypes of breast cancer.

The Teams' goals include: expanding the underlying molecular understanding of each subtype of breast cancer in order to better understand the efficacy of a given therapy; evaluating the mechanisms that lead to therapy resistance within the different subtypes of breast cancer; understanding the role stem cells, or cells known to be the biological foundation of human breast cancer, play in each subtype of breast cancer; developing cell line and laboratory models of each breast cancer subtype; and developing an information distribution center to allow the greater scientific community to benefit from this knowledge.

Jordan's research will be part of Lombardi's Nina Hyde Center for Breast Cancer Research, which is home to a dedicated corps of more than 30 faculty members working exclusively on the prevention and cure of breast cancer. The Nina Hyde Center, founded in honor of the late W
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Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

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