Navigation Links
Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
Date:3/20/2009

r (Erbitux, Avastin), lung cancer (Avastin), and blood cancers (Rituxan, Campath), but they have appeared to primarily work by forcing tumor related receptors to shut down pro-growth signals, Weiner says.

"For years it has been presumed that the ability of antibodies to interfere with malignant cell-related signaling is the dominant mechanism of anticancer activity, but we have also known that the normal job of an antibody is to deliver an antigen to the body's immune system which then destroys the target," Weiner says.

Recent research by Weiner and others, however, now shows that antibodies can inhibit function not only as signaling manipulators but also as initiators of immune responses that leads to control of cancer, the authors say.

"We believe that Herceptin and Rituxan, as examples, work in part by immunizing people against cancer, but at this point, the magnitude of that response is variable and is frequently very small," Weiner says.

Scientists now believe that it will be possible to alter the antibodies so that they induce both kinds of human immunity the innate immune response that is short-lasting and which directly kills tumor cells, and a long-lasting "memory" response that comes from the adaptive immune response. "We have long thought that monoclonal antibodies are capable of stimulating the innate immune system, but we now have evidence that the therapy can prime an adaptive response as well. Such responses would make the treatment much more powerful, capable of keeping cancer under control," he says.

"For the first time we are using technology that can measure the immune response that is occurring in monoclonal antibody treatment, and which will help us build better antibodies that amplify and shape that immune response to become more powerful," Weiner says.

And in the future, it may be possible to build antibodies that are targeted to existing targets on a patient's tumor, as well as to tar
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Harmonizing biobank research: An achievable world-wide goal
2. Toothsome research: Deducing the diet of a prehistoric hominid
3. K-State research: Freshwater pollution costs US at least $4.3 billion a year
4. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
5. Robotics research: Enhancing the lives of people with disabilities
6. Advances in the field of schizophrenia research: New genetic factors identified
7. New research: Fruit juice consumption not related to overweight in children
8. Paradigm shift in Alzheimerss research: new treatments
9. Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses
10. Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses
11. Evolution in action: Our antibodies take evolutionary leaps to fight microbes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology , ... announced the availability of the VeriLook Surveillance ... 3.0 provides real-time biometric face identification using live ... surveillance cameras. The new version not only identifies ... people from objects while they are moving through ...
(Date:10/14/2014)... N.Y. – Scientists have sequenced the house fly genome ... one might expect from an insect that thrives in ... published Oct. 14 in the journal Genome Biology ... biology and of how flies quickly adapt to resist ... Adult house flies (Musca domestica) carry and transmit more ...
(Date:10/14/2014)... – Scientists from The Scripps Research Institute (TSRI) have ... Health (NIH) to lead an investigation of Lassa fever ... Africa. The study aims to understand how Lassa fever ... others survive the inflection. , "The ultimate goal ... how Lassa fever virus causes disease and develop new ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... genetically modified to brandish a powerful "on-switch" that prompts ... finding, from researchers at St. Jude Children's Research Hospital, ... who receive treatment for acute lymphoblastic leukemia (ALL) or ... study are published in the current online issue of ...
... gas pump could come in the form of corncobs, ... a joint feasibility study for the departments of Agriculture ... Laboratory report outlines a national strategy in which 1 ... is available on a renewable or recurring basis ?would ...
... most accurate estimates of the causes of child deaths ... THE LANCET, reveal that worldwide more than 70% of ... attributable to six causes: pneumonia (19%), diarrhoea (18%), malaria ... and asphyxia at birth (8%). , Robert Black (Johns ...
Cached Biology News:Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells 2Human Cells Filmed Instantly Messaging for First Time 2New Estimates For The Causes Of Child Deaths Worldwide 2
(Date:10/17/2014)... Oct. 16—As in Alice,s journey through the looking-glass to ... in surprising and unexpected ways, including a new class ... As reported today in The Optical Society,s (OSA) new ... demonstrated, for the first time, a new type of ... instead reflects infrared light by using an unusual magnetic ...
(Date:10/17/2014)... Horsham, PA (PRWEB) October 17, 2014 ... is being called upon by health facilities around ... exposed patients are being treated. Among the many ... used includes Texas Health Presbyterian Hospital Dallas and ... Center. The state-of-the-art vapor-producing robots have been utilized ...
(Date:10/17/2014)... (PRWEB) October 17, 2014 The Europe ... additives market in Europe with analysis and forecast of ... Fuel Additives Market report, to get an idea of ... of the segmentation in the European fuel additives market, ... , http://www.micromarketmonitor.com/market/europe-fuel-additives-5379768082.html , Fuel additives are chemicals ...
(Date:10/17/2014)... The Middle East and Africa Location Based Services (LBS) market ... East and Africa with analysis and forecast of revenue. This ... to $3,403.1 million by 2019, at a CAGR of 38.5% ... the Middle East and Africa Location Based Services (LBS) market ... It also provides a glimpse of the market segmentation, and ...
Breaking Biology Technology:Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 2The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 4The Middle East and Africa Location Based Services (LBS) market is estimated to reach $3,403.1 million by 2019 - New Report by MicroMarket Monitor 2The Middle East and Africa Location Based Services (LBS) market is estimated to reach $3,403.1 million by 2019 - New Report by MicroMarket Monitor 3The Middle East and Africa Location Based Services (LBS) market is estimated to reach $3,403.1 million by 2019 - New Report by MicroMarket Monitor 4
... Aug. 14 CJPS Enterprises, LLC, the,operator of ... it,has put online more resources for Michigan companies ... to grow their existing healthcare,business. Those resources can ... project is dedicated to providing users with information ...
... XI,AN, China, Aug. 14 /Xinhua-PRNewswire-FirstCall/ -- Huifeng Bio-,Pharmaceutical ... and producer of plant extracts and pharmaceutical raw ... is pleased to,announce record sales and earnings for ... 2008., "In the first half of 2008, ...
... China Sky One,Medical, Inc. (,China Sky One ... ), a,leading fully integrated pharmaceutical company producing ... of China ("PRC"), today,announced that it successfully ... prevention of rheumatic disease., Heilongjiang Tianlong ...
Cached Biology Technology:The Michigan Life Sciences Pipeline Adds More Resources On Its Website 2Huifeng Bio-Pharmaceutical (HFGB) Reports over $5 Million in Gross Sales; Record Results for the First Half of 2008 2China Sky One Medical, Inc. Develops Nasal Spray for Rheumatic Disease 2China Sky One Medical, Inc. Develops Nasal Spray for Rheumatic Disease 3