Washington, DC Scientists at the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC) were awarded a five-year $7.5 million grant to tease apart in the most comprehensive way ever devised the role of a single protein receptor in breast cells in cancer development and treatment. This protein determines which women will develop the most common kind of breast cancer and how she will fare during her treatment. The researchers' ultimate goal is to develop more advanced and better targeted therapies.
"We're combining the strengths of top scientists in this large-scale team science approach to achieve a new level of understanding of the estrogen receptor. That will allow us to make more meaningful predictions about clinical treatment of breast cancer and to be able to correctly identify new targets for therapy," says Robert Clarke, PhD, DSc, a professor of oncology and physiology & biophysics at Lombardi, and interim director of GUMC's Biomedical Graduate Research Organization. Clarke is the principal investigator of the new Center.
The National Cancer Institute (NCI) awarded the grant to Clarke and his team, which includes Leena Hilakivi-Clarke, PhD, professor of oncology at Lombardi; and Louis M. Weiner, MD, Lombardi's director. Georgetown joins ten other institutions across the United States to house a prestigious Center for Cancer Systems Biology.
"These centers represent a unique multidisciplinary union of outstanding scientists and clinicians who will work to unravel the complexities of cancer through the novel application of technology and mathematical modeling. Their discoveries and models will be critical to our continued success in understanding and treating this disease," said Dan Gallahan, PhD, program director for the NCI's Integrative Cancer Biology Program.
"This program is part of the next generation of cancer research, in that it will approach the disease from a holistic or compre
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Georgetown University Medical Center