Navigation Links
Location, location, location important for genes, too
Date:8/29/2008

COLUMBUS, Ohio Cells become cancerous mainly because they lose control of their growth. To better understand how this happens, a new study at Ohio State University's Comprehensive Cancer Center looks at four genes that help regulate cell growth in embryos and that contribute to cancer in adults.

The genes E2f1, E2f2, and E2f3a and E2f3b are generally believed to work together to help control cell proliferation, a belief that comes from experiments using only cells. Cancer researchers at The Ohio State University carried out several studies in an animal model to learn if it is also true in the body during development.

The scientists also hoped to learn why many organisms, including humans, have multiple E2F genes of this type, while other animals have just one copy.

Their study, published in the Aug. 28 issue of the journal Nature, shows that mice need just one of the four genes to develop from fertilized eggs through adulthood.

"We found that if E2f3a is present, the animals can develop normally through adulthood, even when all the other genes are absent," says study leader Gustavo Leone, an associate professor of molecular virology, immunology and medical genetics at Ohio State's Comprehensive Cancer Center.

Then came the real surprise. To learn if the E2f3a gene was doing something truly critical and different from the other three E2Fs, the scientists swapped it with one of the others they replaced it first with E2f3 gene, then with the E2f1. Neither change made any difference; these "swapped" mice developed quite normally.

"If the E2F3a gene was doing something unique, replacing it with one of the others should prevent development," Leone says. "But the animals still developed just fine.

"We conclude from this that it is the gene's location in the genome, plus the timing and level of its activity, that makes it so important during development," he says.

But if just one of the genes is sufficient for development, why are the others needed?

"Organisms above insects have multiple E2Fs, and these findings don't tell us what the others are doing," Leone says. "We surmise that the other genes are required for adult survival under the stressful conditions in the wild. We are investigating that now."


'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related biology news :

1. Location, location, location
2. New robot scouts best locations for components of undersea lab
3. Relocation of endangered Chinese turtle may save species
4. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
5. Early environment may be key to determining bird migration location
6. Dartmouth researchers identify an important gene for a healthy, nutritious plant
7. 2 Springer authors win important awards from the Ecological Society of America
8. New research on pre-eclampsia in mice may have important implications for humans
9. Peers important for nutrition education among Latinos
10. The benefits of green tea in reducing an important risk factor for heart disease
11. New bee checklist lets scientists link important information about all bee species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/26/2017)... , Jan. 26, 2017  Crossmatch, a leading provider ... new solution aimed at combatting fraud, waste and abuse ... introduced at the Action on Disaster Relief conference in ... point for UN agencies and foreign assistance organizations throughout ... waste and abuse are a largely unacknowledged problem in ...
(Date:1/25/2017)... The Elements of Enterprise Information Security ... of a comprehensive set of business processes and ... identities and providing a secured and documented access ... number of programs opted by enterprises to maintain ... processes and changing policies. However, there are some ...
(Date:1/24/2017)... -- It sounds simple and harmless—an electronic sensor attached ... and alerts parents on their smart phones if, ... But pediatric experts argue that such devices may ... of medical benefits, especially to healthy babies. ... of healthy babies, promising peace of mind about ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... NEW YORK , February 27, 2017 ... up by Stock-Callers.com for evaluation today, and they are: ... ARWR), Pacific Biosciences of California Inc. (NASDAQ: PACB), and ... to an article on ETF Trends, market observers are ... Congress and administration could enact reforms to free cash ...
(Date:2/26/2017)... ... February 26, 2017 , ... Rob Lowe is a well recognized television personality, ... "Informed," focuses on issues that are important to the American public and important to ... has been a hot topic around the world for a few years. , The ...
(Date:2/24/2017)... Tenn. , Feb. 24, 2017 ... ("Provectus" or the "Company"), a clinical-stage oncology and ... regarding the deadline to participate in its previously ... units, consisting of shares of common stock and ... and holders of listed warrants. ...
(Date:2/24/2017)... ... ... FireflySci, Inc is an explosive small business that continues to grow at ... their powerful cuvette and spectrophotometer calibration to the spectroscopy world. Now ... as they add yet another mark on the global map. , With distributors in ...
Breaking Biology Technology: