Navigation Links
Location, location, location important for genes, too
Date:8/29/2008

COLUMBUS, Ohio Cells become cancerous mainly because they lose control of their growth. To better understand how this happens, a new study at Ohio State University's Comprehensive Cancer Center looks at four genes that help regulate cell growth in embryos and that contribute to cancer in adults.

The genes E2f1, E2f2, and E2f3a and E2f3b are generally believed to work together to help control cell proliferation, a belief that comes from experiments using only cells. Cancer researchers at The Ohio State University carried out several studies in an animal model to learn if it is also true in the body during development.

The scientists also hoped to learn why many organisms, including humans, have multiple E2F genes of this type, while other animals have just one copy.

Their study, published in the Aug. 28 issue of the journal Nature, shows that mice need just one of the four genes to develop from fertilized eggs through adulthood.

"We found that if E2f3a is present, the animals can develop normally through adulthood, even when all the other genes are absent," says study leader Gustavo Leone, an associate professor of molecular virology, immunology and medical genetics at Ohio State's Comprehensive Cancer Center.

Then came the real surprise. To learn if the E2f3a gene was doing something truly critical and different from the other three E2Fs, the scientists swapped it with one of the others they replaced it first with E2f3 gene, then with the E2f1. Neither change made any difference; these "swapped" mice developed quite normally.

"If the E2F3a gene was doing something unique, replacing it with one of the others should prevent development," Leone says. "But the animals still developed just fine.

"We conclude from this that it is the gene's location in the genome, plus the timing and level of its activity, that makes it so important during development," he says.

But if just one of the genes is sufficient for development, why are the others needed?

"Organisms above insects have multiple E2Fs, and these findings don't tell us what the others are doing," Leone says. "We surmise that the other genes are required for adult survival under the stressful conditions in the wild. We are investigating that now."


'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related biology news :

1. Location, location, location
2. New robot scouts best locations for components of undersea lab
3. Relocation of endangered Chinese turtle may save species
4. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
5. Early environment may be key to determining bird migration location
6. Dartmouth researchers identify an important gene for a healthy, nutritious plant
7. 2 Springer authors win important awards from the Ecological Society of America
8. New research on pre-eclampsia in mice may have important implications for humans
9. Peers important for nutrition education among Latinos
10. The benefits of green tea in reducing an important risk factor for heart disease
11. New bee checklist lets scientists link important information about all bee species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
(Date:6/23/2016)... , June 23, 2016 ... market research report to its pharmaceuticals section with ... product details and much more. Complete ... across 151 pages, profiling 15 companies and supported ... at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The ...
Breaking Biology Technology: