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Location, location, location: Membrane 'residence' gives proteases novel abilities
Date:11/16/2012

nt. "Rhomboid proteases have watery inner chambers. If the slinky shape falls apart inside, the protein gets cut. If the slinky shape remains intact, it doesn't get cut."

This insight, says Urban, opens possibilities for better understanding several diseases and ultimately for developing treatments. For example, he says, the protein that builds up in the brain of Alzheimer's patients is a target for another type of membrane-resident protease that isn't well understood either.


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Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

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