Navigation Links
Local therapy followed by treatment with EGFR TKI is well tolerated
Date:2/22/2013

DENVER Local therapy is not commonly utilized in metastatic lung cancer. Researchers at Memorial Sloan-Kettering Cancer Center investigated the efficacy of local therapy with continued EGFR TKI therapy specifically in patients with acquired resistance to EGFR TKIs. A recent study published in the March 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, found that EGFR- mutant lung cancers with acquired resistance to EGFR TKI therapy are amenable to local therapy to treat oligometastatic disease when used in conjunction with continued EGFR inhibition.

Eighteen patients were identified who received elective local therapy (surgical resection, radiofrequency ablation or radiation). Local therapy was well-tolerated, with 85 percent of the patients restarting TKI therapy within one month of local therapy. Local therapy with surgery, radiation, or radiofrequency ablation in selected patients is associated with a median overall survival of 41 months, a median time to progression of 10 months, and a median time to next systemic therapy of 22 months.

Researchers report that, "these remarkable outcomes in patients with EGFR mutant lung cancer are likely a result of multiple factors including the unique clinical course of this disease, patient selection, continued benefits of the TKI even after progression, and potential benefits of local therapy."

They also say, "While the patients reported here had long median overall survivals and delayted time to disease progression, there was a wide range of outcomes. Outcomes appeared to be best when the site of local therapy was the only known site of disease." Their experience suggests, "local therapy should be considered for patients with oligometastatic lung cancer with acquired resistance to EGFR TKI."


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related biology news :

1. Chinese scientists discover evidence of giant pandas population history and local adaptation
2. Maple syrup, moose, and the local impacts of climate change
3. Greater effort needed to move local, fresh foods beyond privileged consumers
4. Global economic pressures trickle down to local landscape change, altering disease risk
5. In Fiji, marine protection gets local boost
6. Long-distance distress signal from periphery of injured nerve cells begins with locally made protein
7. First paternity study of southern right whales finds local fathers most successful
8. Managing biodiversity data from local government
9. New therapy for heart failure may enhance bodys stem cell response at cardiovascular injury site
10. Cell therapy a little more concrete thanks to VIB research
11. Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... This news release is available in German . ... we as individuals prompt our fellow humans to behave ... to social dilemmas in game theory. Previous studies assumed ... large groups. Nonetheless, scientists from the Max Planck Institute ... us can exert an influence on the cooperative behaviour ...
(Date:10/30/2014)... 29, 2014  Securus Technologies, a leading ... solutions for public safety, investigation, corrections and ... exciting enhancements to its THREADS™ product, which ... actionable intelligence and focused leads for investigators. ... technological innovation through identifying and delivering solutions ...
(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... tools of physics to show how our circadian clocks ... environment. , In an article appearing March 13 ... Ecole Polytechnique Federale de Lausanne demonstrate that the stability ... recent association studies in families affected by advanced sleep ...
... molecule and snake venom may provide researchers with a ... new drugs. , Purdue University researchers bound a complex ... that was delivered to specific proteins in living venom ... a better way to ascertain the presence, concentration and ...
... A new statistical method of determining genetic traits that ... productive livestock. , Scientists from Purdue University, the ... to choose animals that are more congenial in groups, ... geneticist. The new method is a tool that may ...
Cached Biology News:Keeping the body in sync -- The stability of cellular clocks 2Scientists use nanoparticle to discover disease-causing proteins 2Scientists find method to pick noncompetitive animals, improve production 2
(Date:10/27/2014)... 2014 New Q4-2014 incentives help ... an industry leading unified communication and collaboration provider, ... to deliver cloud-based audio and web/video conferencing solutions ... With SoundConnect’s Q4 incentive partners will ... web conferencing licenses sold, now through December 31st, ...
(Date:10/27/2014)... HORSHAM, Pa. , Oct. 27, 2014 /PRNewswire/ ... Colitis Foundation of America (CCFA) announced today the ... , an educational campaign designed ... bowel diseases (IBD) on the paired role of ... To view the multimedia assets associated with ...
(Date:10/25/2014)... The report “Adipic Acid Market by Application, by ... & Forecast to 2019” report analyzes the adipic ... and trends in different regions. , Browse 119 ... 217 slides and in-depth TOC on “Adipic Acid ... http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers will receive 10% ...
(Date:10/25/2014)... 24, 2014 DuPont Pioneer and ... more than double the acreage contracted for Plenish® ... its soybean crush facility in Salisbury, Md. The ... will target several markets including foodservice and food ... performance. , For the 2015 growing season, Perdue ...
Breaking Biology Technology:SoundConnect Unveils Q4 Partner Incentives 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 2DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 3DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 4
... signing to follow his presentation, WASHINGTON, Sept. ... global marketplace, and the role of,financing are focus ... presentations will focus on the convergence of the,MedTech ... patient monitoring,technologies, critical issues to consider when entering ...
... Detecting deadly fumes in subways, toxic gases in ... becoming easier and more efficient with a measurement ... the technique,s sensitivity, scientists must design better scattering ... , Researchers at the University of Illinois, led ...
... in secret. , Most people did not know that ... Sandia National Laboratories was contributing important information to the ... that cause the disease anthrax. The spores were mailed ... offices and to two U.S. senators. Five people were ...
Cached Biology Technology:Former Speaker of the House Newt Gingrich Featured Wednesday 2Killer pulses help characterize special surfaces 2FBI unveils science of anthrax investigation 2FBI unveils science of anthrax investigation 3