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Living microprocessor tunes in to feedback
Date:6/12/2012

roduction in response to a decrease in the flow of precursors. This is achieved by the digestion of Dgcr8 mRNA, which structurally mimics miRNA. By keeping levels in line with precursor miRNAs, the Microprocessor thus reduces its chances of chopping off-target RNAs.

Since small RNAs are produced synthetically as possible new therapies for a number of diseases, this research may direct efforts to efficiently produce such therapies in the future. In addition, many other biological systems need to balance efficiency with specificity, and the team's findings suggest that many may do so in a similar way.


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Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

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