Navigation Links
Living longer thanks to the 'longevity gene'
Date:2/3/2009

This release is available in German.

A variation in the gene FOXO3A has a positive effect on the life expectancy of humans, and is found much more often in people living to 100 and beyond moreover, this appears to be true worldwide. A research group in the Faculty of Medicine at the Christian-Albrechts-University in Kiel (CAU) has now confirmed this assumption by comparing DNA samples taken from 388 German centenarians with those from 731 younger people. The results of the study appear this week in the prestigious American scientific journal Proceedings of the National Academy of Sciences ("PNAS").

Previously, in September 2008, an American research team led by Bradley J. Willcox had published in PNAS a study that indicated a higher frequency of this genetic variation in long-lived Americans of Japanese origin (ages 95 and above). Professor Almut Nebel, the scientific leader of the "Research Group for Healthy Ageing" at Kiel, comments: "That published result is only of scientific value if it can be confirmed in a study with an independently chosen sample population. Without that there must still remain a tinge of doubt. We have now eliminated that uncertainty about the connection between FOXO3A and longevity, both by our results from the German sample study and by the support from our French partners in Paris, whose research on French centenarians showed the same trend. This discovery is of particular importance as there are genetic differences between Japanese and European people. We can now conclude that this gene is probably important as a factor in longevity throughout the world."

FOXO3A is of great interest for genetic research on ageing, since it was reported in the 1990s that the gene was connected with ageing processes in worms and flies. It is because of those observations that the Kiel research group at the Institute of Clinical Molecular Biology has been working for a long time on variations of this gene in humans.

"The most difficult problem is to get enough old people, especially those aged 100 or more, to take part in such a study. Interestingly, the genetic effects are much more evident in 100-year-olds than in 95-year-olds", notes the first author of the report, Dr. Friederike Flachsbart of the Institute of Clinical Molecular Biology at Kiel University. However, through the support of the Schleswig Holstein biobank Popgen, which now contains over 660 DNA samples from centenarians, the institute in Kiel has access to one of the world's largest collections of DNA samples from long-lived research subjects.


'/>"/>

Contact: Dr. Almut Nebel
a.nebel@mucosa.de
49-043-159-71373
Kiel University
Source:Eurekalert

Related biology news :

1. Reproductive life of male mice is increased by living with females
2. MIT nanotubes sniff out cancer agents in living cells
3. Novel technique for fluorescence tomography of tumors in living animals
4. New method provides panoramic view of protein-RNA interactions in living cells
5. Living fossil tree contains genetic imprints of rain forests under climate change
6. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
7. NSF funds new Center for the Physics of Living Cells at Illinois
8. Buckyballs have high potential to accumulate in living tissue
9. Living sensor can warn of arsenic pollution
10. Nothing stops an expert in the art of living
11. Simian foamy virus found in several people living and working with monkeys in Asia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
Breaking Biology Technology: