Navigation Links
Liver protein crucial for pregnancy
Date:6/30/2013

This news release is available in French.

A protein first shown to function in the liver plays a crucial role in pregnancy in mice and has a key role in the human menstrual cycle, according to researchers at the University of Montreal. Mice that were genetically engineered not to produce the liver receptor homolog-1 (Lrh-1) molecule were unable to create the uterine conditions necessary for establishing and sustaining pregnancy, resulting in the formation of defective placentas. The researchers then showed that Lhr-1 was present in the human uterus and the essential processes related to the success of early gestation. "We previously showed that Lrh-1 is essential for ovulation. Our newest studies have revealed that it is plays an important role in the uterus, raising the possibility that Lrh-1 deficiency contributes to human gestational failure," explained lead author Bruce Murphy, of the university's Animal Reproduction Research Centre. "We worked with mice before looking at human tissues. I believe it premature to propose determination of Lrh-1 in uterine biopsies as a diagnostic tool, but we are working on determining the receptor's pattern of expression across the menstrual cycle."

The researchers also looked at whether hormone replacement therapy might restore normal uterine functions in the mice. "Progesterone did not make a difference. Although hormone therapy allowed for the embryos to implant, we saw problems with the lining in the uterus, compromised formation of the placenta, fetal growth retardation and fetal death," Murphy said. "However, there are new Lrh-1 agonists and antagonists, currently in clinical trials to treat hepatic consequences of type II diabetes, and thus therapeutic intervention might be possible."


'/>"/>

Contact: William Raillant-Clark
rw.raillantclark@gmail.com
514-566-3813
University of Montreal
Source:Eurekalert

Page: 1

Related biology news :

1. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
2. Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
3. Researchers unravel genetic mechanism of fatty liver disease in obese children
4. Commonly used diabetes drug may help to prevent primary liver cancer
5. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
6. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
7. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
8. Family history of liver cancer increases risk of developing the disease
9. Modest alcohol intake associated with less inflammation in patients with common liver disease
10. Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
11. Cancerous tumors deliver pro-metastatic information in secreted vesicles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/22/2017)... LIVERMORE, Calif. , March 21, 2017 ... recognition analytics company serving law enforcement agencies, announced today ... Sheridan as director of public safety business development. ... of diversified law enforcement experience, including a focus on ... Vigilant. In his most recent position, Mr. Sheridan served ...
(Date:3/13/2017)... Germany , March 13, 2017 Future of security: ... ... DERMALOGs Face Matching enables to match face ... forms the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... Alisa Wright, ... Distinguished Alumni Awards from the Purdue College of Pharmacy in Lafayette, Indiana. , ... Pharmacy Program for achievements in their careers and other scientific endeavors. , Wright ...
(Date:4/19/2017)... ... April 19, 2017 , ... Nobilis Therapeutics Announces Completion ... to Leverage Clinical Data in its Upcoming Post Traumatic Stress Disorder Trial , ... patient clinical trial assessing efficacy of its NBTX-001, a xenon-based therapeutic in the treatment ...
(Date:4/19/2017)... ... 19, 2017 , ... WHO: Peggy Lillis Foundation, the preeminent ... advocacy. Founded in 2010 in memory of a single-parent mom and kindergarten teacher ... the most-consulted source for patient-focused information on C. diff infections in the nation. ...
(Date:4/19/2017)... April 19, 2017 A new report published by Allied ... 2014-2022 ," the global market was valued at $6,769 million in 2015, and ... from 2016 to 2022. ... Allied Market Research Logo ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) The cross-flow ...
Breaking Biology Technology: