Navigation Links
Live from the scene: Biochemistry in action
Date:8/8/2011

Researchers can now watch molecules move in living cells, literally millisecond by millisecond, thanks to a new microscope developed by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Published online today in Nature Biotechnology, the new technique provides insights into processes that were so far invisible.

By combining light-sheet microscopy and single molecule spectroscopy, the new microscope can record the fluorescence of every pixel within view, and take snapshots at intervals of less than one millisecond. With it, scientists can watch and measure very fast processes, such as the way molecules diffuse, across a whole sample, even one containing several cells. This is a considerable step up from previous techniques, based on confocal microscopy, in which researchers could only observe at most a few isolated spots in a sample at a time.

"It's really visual biochemistry," says Malte Wachsmuth, who developed the microscope at EMBL. "We can follow fluorescently-tagged molecules in whole live cells, in 3D, and see how their biochemical properties, like interaction rates and binding affinities, vary throughout the cell."

Until now, chromatin the combination of DNA, RNA and proteins that forms chromosomes had been observed in two states: wound tightly together, with most of its DNA inaccessible to the cell's gene-reading machinery, in which case it is called heterochromatin; or loosely packed and easily readable, called euchromatin. But when they used the new microscope to measure the interaction between chromatin and a protein called HP1-α, the EMBL scientists made an intriguing discovery.

"In some areas that look like euchromatin, HP1-α behaves as it would in the presence of heterochromatin," says Michael Knop, now at the University of Heidelberg, Germany. "This suggests that chromatin may also exist in an intermediate state between hetero- and euchromatin, which was n
'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. MSU lands $4.1 million grant to unlock plants biochemistry secrets
2. Biochemistry of how plants resist insect attack determined
3. The GW Department of Biochemistry and Molecular Biology to host Nobel Laureate Dr. Ferid Murad
4. American Society for Biochemistry and Molecular Biology reacts to stem-cell ruling
5. American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists
6. NSF grant will develop new online hub for biochemistry, molecular biology educators
7. Springer partners with the American Society for Biochemistry and Molecular Biology
8. ASBMB Annual Meeting to feature talks on the biochemistry of aging
9. Phytoplankton cell membranes challenge fundamentals of biochemistry
10. Biochemistry of human physiology in health and disease is focus of updated clinical text
11. Catching the West Nile virus in action
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Live from the scene: Biochemistry in action
(Date:6/16/2015)... June 16, 2015 /CNW Telbec/ - handyem Inc. ... around the incorporation of handyem,s HPC-150 portable flow ... the Mo-POD™. This unprecedented model of mobile laboratory ... at the Pennsylvania Convention ... 15 th to 18 th 2015. ...
(Date:6/15/2015)... 2015 A new report [ ... majority of US consumers using mobile banking applications want their ... fingerprint and voiceprint, instead of having to prove who they ... " Mobile Identity   -   The Fusion of Financial ... now the primary channel used by Gen X and Gen ...
(Date:6/9/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, will be providing demonstrations of its ... Drug Information Association (DIA) Annual Meeting in ... will include previews of many exciting new enhancements that ... iMedNet 2015 Feature 1 Release. ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 3
... actions and dispositions of strangers by observing others ... show an ability to recognize certain behavioral traits ... of these traits in strangers in similar situations ... from the George Washington University in Washington DC ...
... INDONESIA In an investigative report published today by Eyes ... in Riau Province -- strongly indicated as illegally built by ... cutting into the heart of Sumatras largest contiguous peatland forest, ... planets biggest carbon stores. The road would allow ...
... researchers showed for the first time that a natural ... help destroy pancreatic cancer cells by reaching to the ... function. The study is published in the March edition ... The study also showed that when the pancreatic ...
Cached Biology News:Who's bad? Chimps figure it out by observation 2Logging road threatens rare peat dome, tigers 2Logging road threatens rare peat dome, tigers 3Mounting evidence shows red wine antioxidant kills cancer 2Mounting evidence shows red wine antioxidant kills cancer 3
(Date:7/2/2015)... ... July 02, 2015 , ... In’Tech Medical SAS ( ... Orthopedics, announced today the acquisition of Turner Medical, Inc ., thus becoming ... instruments to the Spine Industry. The acquisition of Turner Medical ideally supplements In’Tech ...
(Date:7/1/2015)... July 1, 2015   Decision Resources Group ... advantages of Otezla are its oral administration, alternative ... reported by surveyed rheumatologists. Otezla was the first ... treatment of active psoriatic arthritis in ... of care includes conventional oral treatments including disease-modifying ...
(Date:7/1/2015)... July 1, 2015   Neuraltus Pharmaceuticals, Inc. ... of groundbreaking drugs to treat neurodegenerative diseases such ... Robert G. Miller , M.D., Director of the ... California Pacific Medical Center in San Francisco, has been ... $1.5 million to help fund a Phase 2 ...
(Date:7/1/2015)... Wilmington, DE (PRWEB) , ... July 01, 2015 , ... ... to develop new ideas to lower the barriers to innovation in life sciences R&D. ... for up to two cash prizes of US$15,000 and a period of expert mentorship ...
Breaking Biology Technology:In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3
... Health Care Compliance Strategies, Inc. (HCCS) , ... training, today announced the release of a new online ... Associates (BAs) . Responding to expanded HIPAA Privacy Rule ... an online course designed to assist healthcare vendors in ...
... , a venture backed clinical stage biotechnology company developing ... from the Phase 2b trial of ARC-4558 for the ... will be the subject of two poster presentations at ... at the American Diabetes Association,s 71st Scientific Sessions, June ...
... Reportlinker.com announces that a new market research ... Global Immunochemicals Industry ... report analyzes the worldwide markets for Immunochemicals ... segments – Catalog Antibodies, and Custom Antibodies. ...
Cached Biology Technology:New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 2New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 3Arcion Therapeutics to Present ARC-4558 Phase 2b Data for the Treatment of Pain Associated With Painful Diabetic Neuropathy at Upcoming Medical Meetings 2Arcion Therapeutics to Present ARC-4558 Phase 2b Data for the Treatment of Pain Associated With Painful Diabetic Neuropathy at Upcoming Medical Meetings 3Reportlinker Adds Global Immunochemicals Industry 2Reportlinker Adds Global Immunochemicals Industry 3Reportlinker Adds Global Immunochemicals Industry 4Reportlinker Adds Global Immunochemicals Industry 5Reportlinker Adds Global Immunochemicals Industry 6Reportlinker Adds Global Immunochemicals Industry 7Reportlinker Adds Global Immunochemicals Industry 8Reportlinker Adds Global Immunochemicals Industry 9Reportlinker Adds Global Immunochemicals Industry 10
Request Info...
... siRNA and miRNA Isolation Traditional mRNA ... mRNA and can result in the loss ... mirVana miRNA Isolation Kit purifies all RNA ... double-stranded. Through an enrichment procedure included in ...
... peptide derived from the internal region of ... Specific for the internal region of the ... the target band at ~590 kDa. ... media from primary tracheobranchial epithelial cultures and ...
Request Info...
Biology Products: