Navigation Links
Little-known protein found to be key player
Date:7/29/2009

ly development. They also created mutant versions of the protein to see how it functioned -- or failed to function -- when some parts were disabled.

The tests showed that cells with extra atlastin had an overdeveloped endoplasmic reticulum (ER), a system of interconnected membrane tubes and chambers that's critical for normal cell function. The tests also showed too little atlastin led to a fragmented ER. Flies with defective atlastin were sterile and short-lived.

"The endoplasmic reticulum is an ever-changing environment," McNew said. "It grows. It retracts. It expands. It collapses. It's highly dynamic, and for that to be the case, there has to be a mechanism by which it can grow new pieces and connect those pieces together. That's where the fusion comes in."

Daga said the discovery will lay the foundation for a deeper understanding of both basic biological processes and disease.

"We hope the findings lead to a better understanding of hereditary spastic paraplegia (HSP), the genetic disorder that atlastin has been linked with," Daga said.

HSP is a rare genetic condition that affects fewer than one million people worldwide. It's marked by a partial paralysis of the lower extremities due to defects in the body's longest cells, the neurons that run from the spine through the legs.

Daga said atlastin's role in building and maintaining a healthy ER may help HSP researchers better understand why neurons are affected first.

"This is the first clue," Daga said. "We have the definition of what the protein does. Now we need to explore how it does that, and what it means."


'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Book on little-known species and conservation provides guidance to managers and others
2. MSU researcher uses grant to study little-known but largely useful microbes
3. Protein chatter linked to cancer activation
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. Low levels of key protein may indicate pancreatic cancer risk
7. Structure of 450 million year old protein reveals evolutions steps
8. Scientists retrace evolution with first atomic structure of an ancient protein
9. Specific brain protein required for nerve cell connections to form and function
10. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Little-known protein found to be key player
(Date:6/17/2015)... GARDENS, Fla. , June 17, 2015 /PRNewswire/ ... solutions, today announced that its U.are.U ® ... Togo,s Eateries, Inc., a ... casual sandwich chain, to increase security, improve accountability ... fingerprint readers enable instant, non-repudiable identity confirmation for ...
(Date:6/15/2015)... June 16, 2015 According to ... by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, ... 2020" published by MarketsandMarkets, The Natural Language Processing Market ... CAGR of 18.4% for the forecast period 2015-2020. ... 46 F igures spread   through 155 P ...
(Date:6/10/2015)... June 10, 2015 According ... Market by Technology (Ultrasound, TOF, Structured Light, Stereo ... Entertainment, Automotive) and by Geography - Trends & ... the market is expected to reach $3,319.71 Million ... between 2015 and 2020. Browse 71 ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 53D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4
... over the past 100 years, potentially endangering coast redwood trees ... by University of California, Berkeley, scientists. , It is unclear ... result of human activity, but the change could affect not ... say. , "Since 1901, the average number of hours of ...
... underlying mechanism is shared by a group of previously ... development and function. Rett syndrome (RTT), Cornelia de Lange ... have each been linked with distinct abnormalities in chromatin, ... chromosomes and control how genetic information is read in ...
... cells convert nutrients into energy could offer new approaches ... and stroke. Using a new way to screen ... Hospital (MGH) researchers has identified several FDA-approved agents, including ... metabolism processes in animals. Their findings, being published ...
Cached Biology News:Fog has declined in past century along California's redwood coast 2Fog has declined in past century along California's redwood coast 3Fog has declined in past century along California's redwood coast 4A common thread links multiple human cognitive disorders 2Shifting cellular energy metabolism may help treat cardiovascular disease 2Shifting cellular energy metabolism may help treat cardiovascular disease 3
(Date:6/29/2015)... , ... June 29, 2015 , ... ... B2. Under the terms of the agreement, MediVet will acquire the rights to ... (UCMSCs). MB-007 is currently in pre-clinical development as a potential next-generation treatment for ...
(Date:6/29/2015)... , June 29, 2015  Neuralstem, Inc. (NYSE ... technology to develop small molecule and cell therapy treatments ... has been approved for listing on the NASDAQ Capital ... will continue to trade on the NYSE MKT until ... the NASDAQ Capital Market is expected to commence on ...
(Date:6/29/2015)... 29, 2015 Elsevier , ... products and services, today announced the highlights of its ... 2014 Journal Citation Reports® (JCR) published by Thomson Reuters, ... from 2013 to 2014, ahead of the aggregate across ... rank in 62 subject categories, up from 61 in ...
(Date:6/26/2015)... June 26, 2015  A San Francisco company, Pembient, ... with synthetic rhino horn: beer in China ... . In response to the emerging industry, two ... and sale of synthetic rhino horn.  ... Save the Rhino International (SRI) released a ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... 16, 2012  That our chromosomes can break and reshuffle pieces ... decades, especially in cancer cells. The rules for where chromosomes ... together are only just now starting to come into view. ... Immune Disease Institute (IDI) have helped bring those rules ...
... led by a University of British Columbia professor has developed ... a brief, sudden loss of consciousness in rats, ... seizures, also known as "petit mal seizures," are a symptom ... the person looks awake but dazed. The seizures, arising from ...
... Feb. 15, 2012 The Alfred P. Sloan Foundation ... U.S. and Canadian researchers as recipients of Sloan Research ... are given to early-career scientists and scholars whose achievements ... generation of scientific leaders. "Today,s Sloan Research ...
Cached Biology Technology:To Understand Chromosome Reshuffling, Look to the Genome's 3D Structure 2To Understand Chromosome Reshuffling, Look to the Genome's 3D Structure 3To Understand Chromosome Reshuffling, Look to the Genome's 3D Structure 4New drugs show promise for preventing 'absence seizures' in children: UBC research 2Sloan Research Fellowships Awarded to 126 Young Scholars 2
...
...
Verotoxin IIbeta (457)...
Thermo Labsystems offers a basic reader for 96-well microplates that is especially adapted for ELISA and other colorimetric assays....
Biology Products: