Navigation Links
Little-known protein found to be key player
Date:7/29/2009

HOUSTON -- (July 29, 2009) -- Italian and U.S. biologists this week report that a little-understood protein previously implicated in a rare genetic disorder plays an unexpected and critical role in building and maintaining healthy cells. Even more surprising, their report in the journal Nature shows that the protein, called "atlastin," does its work by fusing intracellular membranes in a previously undocumented way.

"If you'd asked me a year ago whether this was possible, I would have said, 'No,'" said study co-author James McNew, associate professor of biochemistry and cell biology at Rice University. "In fact, that's exactly what I told (co-author) Andrea Daga when we first spoke about the idea a year ago."

McNew has spent the past 15 years studying SNARE proteins, a specialized family of proteins that carries out membrane fusion. It's a vital process that happens thousands of times a second in every cell of our bodies.

"It is fitting that the discovery of a new protein capable of fusing membranes comes 10 years after the demonstration that SNAREs can fuse lipid bilayers," said Daga, a researcher at the Eugenio Medea Scientific Institute in Conegliano, Italy.

In the new study, Daga's and McNew's research teams used fruit flies to study how atlastin functions. The atlastin in fruit flies is very similar to the human version of the protein and serves the same function.

"Prior to this, there were only two defined ways in which you could take biological membranes and put them together in a specific way," said McNew, a faculty investigator at Rice's BioScience Resesarch Collaborative. "Atlastin is the third, and it's the only one that requires enzymatic activity, so it's distinctly different."

Using a range of tests on purified proteins, live fruit flies and cell cultures, the Italian and U.S. teams examined the effect of both an overabundance and a scarcity of atlastin on cell function and on fruit f
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Book on little-known species and conservation provides guidance to managers and others
2. MSU researcher uses grant to study little-known but largely useful microbes
3. Protein chatter linked to cancer activation
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. Low levels of key protein may indicate pancreatic cancer risk
7. Structure of 450 million year old protein reveals evolutions steps
8. Scientists retrace evolution with first atomic structure of an ancient protein
9. Specific brain protein required for nerve cell connections to form and function
10. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Little-known protein found to be key player
(Date:4/1/2015)...   Medisafe ™, the leading global medication management ... and Android smartphones and tablets, announces ... platform to allow patients to track and correlate their ... patients will be able to visualize in real-time how ... such as glucose levels and blood pressure. ...
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the ... Business Report" report to their offering. This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... NY, November 20, 2012Mary Ann Liebert, Inc., publishers ... journal dedicated to the science and engineering of soft materials ... first to answer the urgent need for research on robotic ... in complex natural or human-built environments. Soft Robotics ...
... during cardiac surgery can lead to convulsive seizures, but ... research from the Faculty of Medicine at the University ... trauma surgery are often given tranexamic acid (TXA) and ... of Medicine researchers found these drugs are associated with ...
... atomic physics over the past few years are methods that ... temperatures just above absolute zero. Scientists from Bangalore and Mainz ... also be cooled through contact with cold atoms and may ... condition for longer periods of time. This finding runs counter ...
Cached Biology News:'Soft Robotics': A groundbreaking new journal on engineered soft devices that Interact with Living Systems 2Seizures linked to surgery drugs can be prevented by anesthetics, U of T team finds 2Scientists from Bangalore and Mainz develop new methods for cooling of ions 2
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, ... congestive heart failure and other chronic diseases, has ... independent analysis designed to reflect the healthcare patterns ... This model will be used to characterize the ... could have on those groups of patients and ...
(Date:5/5/2015)... Oakland, CA (PRWEB) May 05, 2015 ... Database technology, today announced that its flagship product, AllegroGraph, ... recent Graph Database Market Update report. AllegroGraph ... by leveraging the W3C industry standards. Graph databases are skyrocketing ... two years, according to a recent DBMS ranking ...
(Date:5/5/2015)... 5, 2015   Tocagen Inc. , a ... R. Parkinson , M.D., a venture partner at ... the board of directors of Tocagen. Dr. Parkinson ... oncology clinical development, including leading clinical activities at ... of the cancer therapeutics Gleevec®, Femara®, Zometa®, Kepivance® ...
(Date:5/5/2015)... The Alliance for Clinical Research Excellence and Safety ... public interest, and Texas-based for-profit San Antonio Express-News ... formed a strategic alliance to create a blog as ... healthcare and clinical research endeavor. The blog provides ... public to be clearly heard in this important dialogue. ...
Breaking Biology Technology:RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 3ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 4
... Nanotechnology Victoria (NanoVic) and AZoNetwork are pleased to ... in a Podcast format. , This third Podcast ... features key stakeholders discussing the crucial issues around ... development and translated into successful commercial outcomes. , Dr ...
... Bulletin Board: CNVT) holding BIOREM announced the,receipt of a ... a,Biofiltair odor control system. This order for $280,000 (Cdn) ... is the third order,received from China over the past ... was accepted on these projects,",said Peter Bruijns, President and ...
... RDEA ) today announced that its President and ... the "In Search of the,Next HIV Treatment" panel discussion ... December 12, 2007 at 1:30 p.m. (ET) at,the Westin ... audio webcast of the,presentation and panel discussion will be ...
Cached Biology Technology:Commercialization of nanotechnology 2CVF Technologies Corporation's Holding - BIOREM Announces 3rd Order from China 2Ardea Biosciences to Participate in RBC Capital Markets 2007 Healthcare Conference 2Ardea Biosciences to Participate in RBC Capital Markets 2007 Healthcare Conference 3
... serum is collected from fasted Rhesus monkeys of ... Available Anticoagulants: N-02: Citrate ... K2EDTA N-08: Potassium Oxalate N-10: ... N-05: ACD N-07: CPD ...
Porcine Serum US Origin 6 Months or Older...
SEQUENASE PCR PRODUCT PRE-SEQU, 1 EA. Category: SEQUENASE....
... is collected off the clot from fasted Cynomolgus monkeys ... Available Anticoagulants: N-02: Citrate ... N-08: Potassium Oxalate N-10: EDTA (Na) ... N-07: CPD N-09: K3EDTA N-11: ...
Biology Products: