Navigation Links
Little-known protein found to be key player
Date:7/29/2009

HOUSTON -- (July 29, 2009) -- Italian and U.S. biologists this week report that a little-understood protein previously implicated in a rare genetic disorder plays an unexpected and critical role in building and maintaining healthy cells. Even more surprising, their report in the journal Nature shows that the protein, called "atlastin," does its work by fusing intracellular membranes in a previously undocumented way.

"If you'd asked me a year ago whether this was possible, I would have said, 'No,'" said study co-author James McNew, associate professor of biochemistry and cell biology at Rice University. "In fact, that's exactly what I told (co-author) Andrea Daga when we first spoke about the idea a year ago."

McNew has spent the past 15 years studying SNARE proteins, a specialized family of proteins that carries out membrane fusion. It's a vital process that happens thousands of times a second in every cell of our bodies.

"It is fitting that the discovery of a new protein capable of fusing membranes comes 10 years after the demonstration that SNAREs can fuse lipid bilayers," said Daga, a researcher at the Eugenio Medea Scientific Institute in Conegliano, Italy.

In the new study, Daga's and McNew's research teams used fruit flies to study how atlastin functions. The atlastin in fruit flies is very similar to the human version of the protein and serves the same function.

"Prior to this, there were only two defined ways in which you could take biological membranes and put them together in a specific way," said McNew, a faculty investigator at Rice's BioScience Resesarch Collaborative. "Atlastin is the third, and it's the only one that requires enzymatic activity, so it's distinctly different."

Using a range of tests on purified proteins, live fruit flies and cell cultures, the Italian and U.S. teams examined the effect of both an overabundance and a scarcity of atlastin on cell function and on fruit f
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Book on little-known species and conservation provides guidance to managers and others
2. MSU researcher uses grant to study little-known but largely useful microbes
3. Protein chatter linked to cancer activation
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. Low levels of key protein may indicate pancreatic cancer risk
7. Structure of 450 million year old protein reveals evolutions steps
8. Scientists retrace evolution with first atomic structure of an ancient protein
9. Specific brain protein required for nerve cell connections to form and function
10. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Little-known protein found to be key player
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
(Date:4/22/2014)... for Experimental Biology (FASEB) has released updated factsheets ... from the National Institutes of Health (NIH) benefits each ... is pleased to make these factsheets available to help ... their state," said FASEB President, Margaret K. Offermann, MD, ... research funding, investing $29.2 billion in FY 2013 ...
(Date:4/22/2014)... of breeding bird surveys sent in by citizen scientists ... years, wildlife researchers report that most of the 40 ... higher elevation in response to climate change, but did ... previous studies of potential climate change impacts on wildlife ... have likely underestimated the effects of environmental warming, say ...
Breaking Biology News(10 mins):Wildlife response to climate change is likely underestimated, experts warn 2
... especially in intensive production. Piglets commonly become susceptible to ... to losses of 10% or more. The antibiotics used ... have now fallen out of use, mainly due to ... A radical solution has been found by using a ...
... cushy haploid environs to take up residence in a ... but Indiana University Bloomington scientists report in this week's ... plants. , "Plants that reproduce clonally or are ... mitochondrion to the nucleus," said graduate student Yaniv Brandvain, ...
... that help shape our understanding of how tool use ... chimpanzees, at least under some conditions, are capable of ... The work, reported by Jill Pruetz of Iowa State ... will appear online in the journal Current Biology on ...
Cached Biology News:A healthier start to a pig's life 2Mitochondrial genes move to the nucleus -- but it's not for the sex 2Chimpanzees found to use tools to hunt mammalian prey 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 2014 Freeslate, Inc ., the ... that Lupin Limited, one of India’s top five pharmaceutical ... PharmD System for high throughput solid form screening. ... on a wide range of quality, affordable generic and ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... offers revolutionary orthotic prescription ... ... Technologies will,debut the new Xtremityscan System and give away a free ... at the,Disneyland Hotel., Xtremityscan is a digital shape acquisition system ...
... ... Laboratories, NEW YORK, ... that its Owlstone Nanotech Inc.,("Owlstone") subsidiary has received a purchase order ... IEE, an,innovative developer of specialized sensing systems with a global,leadership position ...
... Genaera,Corporation (Nasdaq: GENR ) today announced that Jack ... present at the BIO,Business Forum. The presentation will provide an ... San Diego Convention Center in San,Diego on Tuesday, June 17, ... will also join a panel of experts to discuss new ...
Cached Biology Technology:PAL Health Technologies Debuts Xtremityscan System at Western Podiatric Medical Congress 2Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 2Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 3Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 4Genaera Corporation to Present at BIO Business Forum 2Genaera Corporation to Present at BIO Business Forum 3
... Vybrant Apoptosis Assay Kit #4 ... that occur in the permeability of cell ... both YO-PRO-1 and propidium iodide nucleic acid ... plasma membranes of apoptotic cells and labels ...
Request Info...
Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. E...
Request Info...
Biology Products: