Navigation Links
Little changes -- large effects
Date:8/30/2013

Scientists at the University of York have discovered that very small chemical changes to dietary flavonoids cause very large effects when the plant natural products are tested for their impact on the human immune system.

Plants are capable of making tens of thousands of different small molecules an average leaf for example, produces around 20,000. Many of these are found in a typical diet and some are already known to have medicinal properties with effects on health, diseases and general well-being.

Now plant biologists and immunologists at York have joined forces to examine a very closely related family of these small molecules (flavonoids) to establish how tiny changes to their chemical structures affect their bio-activity.

The research, published in The Journal of Biological Chemistry, has important implications for diet and in the development of new pharmaceuticals from plant natural products.

Researchers from the Centre for Novel Agricultural Products (CNAP) and the Centre for Immunology and Infection (CII) in the University's Department of Biology designed experiments to test the bioactivity of plant-derived flavonoids.

Professor Dianna Bowles, a plant biochemist and founding Director of CNAP, led the research with Professor Paul Kaye, the Director of CII, who developed the robust assay system involving human cells to assess the impacts of the different structures.

Professor Bowles, who referred to the research in a panel discussion on 'Nature's Marvellous Medicines' at the recent Royal Society Summer Science Exhibition, said: "We were measuring how flavonoids affected the production of inflammatory mediators by cells stimulated by microbial products. We found that the way in which a flavonoid scaffold was decorated had massive effects on how the cells responded. If a methyl group was attached at one site, there would be no effect; methylate another site, and the cells would produce far greater amounts of these inflammato
'/>"/>

Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic secrets of the worlds toughest little bird
2. Solitary lemurs avoid danger with a little help from the neighbors
3. Climate change may have little impact on tropical lizards
4. AACR news: Little molecule makes big difference in bladder cancer metastasis
5. Cell therapy a little more concrete thanks to VIB research
6. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
7. NTU researchers study little mighty creature for scientific breakthrough
8. Chemical fingerprinting tracks the travels of little brown bats
9. Variations of a single gene can lead to too much or too little growth, study shows
10. Changes to symptom structure in DSM-5 support diagnosis of toddlers with autism spectrum disorder
11. Newly discovered bacterial partnership changes ocean chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... such as buying clothing not made in a sweat ... their own bags when they go shopping? According to ... Research , ethical consumption is motivated by a need ... into action. , "Advocates of ethical consumerism suggest that ... the products they choose, but unfortunately only a small ...
(Date:9/16/2014)... responsible for practically all vital functions in an ... signals, transport particular substances and control immune system ... do not function independently of each other, but ... the protein networks, you find many similarities with ... TUM,s Chair of Plant Systems Biology. "Some proteins ...
(Date:9/16/2014)... 16, 2014  Cross Match Technologies, a leading ... today the launch of its Verifier ® ... of an individual using their secure credentials and ... reads credential documents with embedded biometric data and ... biometric to a live scan of their fingerprint. ...
Breaking Biology News(10 mins):Why are consumers willing to spend more money on ethical products? 2Good networkers make prime targets 2Cross Match Launches New Identity Management Handheld Solution 2
... 2012) Norman H. Lee, Ph.D., professor of pharmacology ... Health Sciences (SMHS), received a total of $405,001 in ... (NIDA) to continue to study the correlation between ... fund Lee,s continuing research on drug addiction, titled "Conditional ...
... 29, 2012 Gaining new insight to managing sodium ... Houston (UH) College of Pharmacy believe their work may ... Mohammad Asghar, assistant professor of pharmacology, is exploring the ... hallmarks of the aging process alter the function ...
... robots, Northern Illinois University Professor David Gunkel says science fiction ... intelligence have run the gamut from the loyal Robot in ... A Space Odyssey" and the endearing C-3PO and R2-D2 of ... the stuff of fiction, the issues they raised have never ...
Cached Biology News:GW professor receives grant to study the role of genes in drug addiction 2Aging kidneys may hold key to new high blood pressure therapies 2Morality for robots? 2Morality for robots? 3
(Date:9/15/2014)... phase transitionsthink solid, liquid, and gasbut much ... drops. If phase transitions occur at the ... subtle fluctuations can dramatically transform a material. ... of Energy,s Brookhaven National Laboratory and Stony ... of absolute zero to isolate and probe ...
(Date:9/15/2014)... North Carolina State University have developed a technique for ... very low voltages, opening the door to a new ... The technique hinges on the fact that the oxide ... or removed acts as a surfactant, lowering the ... , The researchers used a liquid metal alloy of ...
(Date:9/15/2014)... , Sept. 15, 2014 Zymo ... viral transport solution for safe ambient temperature storage ... molecular testing. Importantly, the infectivity of agents in such ... maintaining the integrity of the viral nucleic acids ... the recent Ebola epidemic in West ...
(Date:9/15/2014)... September 2014 Die zweite jährliche ... 12. bis 18. Oktober stattfinden. Die IPAW ist ... Association (PPTA) und ihrer Mitgliedsunternehmen ... globale Bewusstsein für die Gewinnung von Quellplasma zu ... Retten und Verbessern von Leben zu würdigen ...
Breaking Biology Technology:Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Researchers control surface tension to manipulate liquid metals 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3
... 2011 Ludwig Institute for Cancer Research LTD (LICR) and ... to expand development of Polaris, novel cancer drug, pegylated arginine ... of the amino acid arginine. As part ... potential of ADI-PEG 20 as a cancer therapy and aim ...
... Md., May 17, 2011 Goodwin Biotechnology, Inc. (GBI), ... a leader in cell line engineering for protein and ... for cell line engineering and biological contract manufacturing.   ... patients with inherited and acquired diseases," said Sung Ho ...
... May 17, 2011 Magellan Biosciences, a global manufacturer ... cost-effective, and less labor intensive, announced that its Vice ... will be a featured speaker at the Medicaid Health ... Awards Forum, which takes place tomorrow in Washington, DC. ...
Cached Biology Technology:Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris' Novel Cancer Drug, ADI-PEG 20 2Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris' Novel Cancer Drug, ADI-PEG 20 3Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris' Novel Cancer Drug, ADI-PEG 20 4Goodwin Biotechnology and RAFAGEN Announce a Collaboration 2Magellan Biosciences to Present at Medicaid Health Plans of America Center for Best Practices First Annual Awards Forum 2Magellan Biosciences to Present at Medicaid Health Plans of America Center for Best Practices First Annual Awards Forum 3Magellan Biosciences to Present at Medicaid Health Plans of America Center for Best Practices First Annual Awards Forum 4Magellan Biosciences to Present at Medicaid Health Plans of America Center for Best Practices First Annual Awards Forum 5Magellan Biosciences to Present at Medicaid Health Plans of America Center for Best Practices First Annual Awards Forum 6
... Daltonics and Bruker BioSpins Metabolic Profiler ... studies, and analysis of complex mixtures. ... an optional Avance NMR spectrometer and ... and statistical analysis for applications like:,Assessment ...
... movements in a Morris Water Maze. Tracks ... predefined sequence of trials.The Spatial Behavior line is ... video camera, frame grabber, and feature extraction software ... and up to 6 moving animals. Software ...
... Object Records behavior directed toward examining a novel ... a family of instruments all built around a ... and that can track two fields at once ... automatically extracts animal positions and records them, but ...
... ACS Reagent Grade C 19 H 9 ... 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity of ... pH 3.0 - Yellow pH 4.6 ... dye in agarose and acrylamide gel electrophoresis. ...
Biology Products: