Navigation Links
Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells
Date:1/13/2014

Two small RNAs (sRNAs) working in concert enable the deadly enterohemorrhagic Escherichia coli (EHEC) 0157:H7 to attach to and initiate infection in epithelial cells that line the digestive tract, according to a study published in mBio, the online open-access journal of the American Society for Microbiology.

Gram-negative bacteria such as EHEC enter their prey and deploy syringe-like weapons called type III secretion systems (T3SS) that inject proteins into the epithelial cells to promote reorganization of the the cytoskeleton into pedestals that act as docking stations for the bacteria to adhere to the cells.

Both pedestal and T3SS formation demand rapid activation and precise coordination of a large number of bacterial genes co-opted from a pathogenicity island called the locus of enterocytes effacement (LEE) which Charley Gruber, Vanessa Sperandio and their colleagues at the University of Texas Southwestern Medical School in Dallas recently discovered is orchestrated by two sRNAs known as GlmY and GlmZ.

"Our data reveal two previously unknown mechanisms of actions for these sRNAs," Sperandio says. "Working together GlmY and GlmZ cleave the transcript between espJ and espFu genes enabling translation of EspFu, a protein important for efficient mammalian-cell invasion, and also destabilize the LEE 4 and 5 transcripts thus fine tuning LEE gene expression."

"Destabilization of LEE is especially important for two reasons first, it permits the differential expression of various genes encoded within the same cluster and second, it ensures that the bacteria are forming optimal pedestal levels on epithelial cells during infection," according to Sperandio. Thus, these researchers propose that these sRNAs are responsible for the dynamic rewiring of the bacterial complex machineries that enable infection.

"This is a very important contribution to the field particularly because it shows that things are
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Young tropical forests contribute little to biodiversity conservation
2. Targeted culling of deer controls disease with little effect on hunting
3. Beyond the little blue pill: scientists develop compound that may treat priapism
4. Little changes -- large effects
5. Genetic secrets of the worlds toughest little bird
6. Solitary lemurs avoid danger with a little help from the neighbors
7. Climate change may have little impact on tropical lizards
8. AACR news: Little molecule makes big difference in bladder cancer metastasis
9. Cell therapy a little more concrete thanks to VIB research
10. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
11. NTU researchers study little mighty creature for scientific breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... division of the striatum is also involved in ... of substance P in the striatal marginal division ... his team, College of Biophotonics, South China Normal ... P receptor, neurokinin 1 was highly expressed in ... rats. Unilateral or bilateral injection of an antisense ...
(Date:7/11/2014)... 2014 Research and Markets has ... Market - Industry Analysis Size Share Growth Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 The ... a need for high level security in both private ... such as username and passwords, tokens etc. are vulnerable ...
(Date:7/10/2014)... Santa Fe, Albuquerque, and other major cities in New ... with treated municipal wastewater rather than precious potable water ... than 40% of all golf courses receive treated effluent. ... , Additionally, golf courses and homeowners alike fertilize ... in fertilizer is nitrate. A New Mexico State University ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... landscape of our planet and the elemental forces that shape ... being led by The University of Nottingham. The Earth ... University,s School of Geography, is a two-year project funded with ... will focus on technology that can be used for a ...
... from the University of Pennsylvania have linked the ... dark contrasts of the natural world, demonstrating the likelihood ... adapted to best capture the world around us. ... darkness are more numerous and cluster closer together than ...
... -- The explosion of portable communication devices that we ... Bluetooth hands-free units, and wireless Internet networks -- has ... variety of integrated circuits that create, process and receive ... Continuing demand for higher performance over a ...
Cached Biology News:Keeping a watch on the world 2Keeping a watch on the world 3The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say 2The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say 3
(Date:7/10/2014)... 10, 2014 Robert Harman, DVM, Founder and ... is proud to announce the relaunch of his highly informative ... new series called “ What are Stem Cells ?” ... and straightforward foundation in the basics of stem cell therapy ... the right type of treatment when considering regenerative medicine. , ...
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)...  Kainos Capital, a firm specializing in acquiring and ... has acquired the Slim-Fast brand from Unilever. Unilever will ... the transaction were not disclosed. Slim-Fast is ... markets ready-to-drink shakes, powders, bars and snacks to retail ... in the United Kingdom and ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... , COLUMBIA, Md., Aug. 20 Martek Biosciences Corporation ... into a multi-year, sole-source supply agreement with Milk Powder Solutions, based ... as Milk Powder Solutions, exclusive supplier for all of its ARA ... Gold Cow brand name. , , "This new ...
... BEIJING, Aug. 20 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. ... China-based medical device,company that develops, manufactures and markets advanced ... unaudited financial results,for the fourth fiscal quarter ("4Q FY2008") ... first fiscal quarter ("1Q FY2009") ended June 30, 2009,before ...
... , BELLE MEAD, N.J., Aug. 19 ... Jersey will streamline and improve the quality of care for patients ... i ng.net ), a leader in healthcare technology. ... to oversee all aspects of practice management and electronic health record ...
Cached Biology Technology:Martek Signs Sole-Source Supply Agreement with Milk Powder Solutions 2Martek Signs Sole-Source Supply Agreement with Milk Powder Solutions 3China Medical Technologies to Announce Unaudited Financial Results for the Fourth Fiscal Quarter and Fiscal Year ended March 31, 2009 and the First Fiscal Quarter ended June 30, 2009 on September 1, 2009 2New Jersey Surgery Centers Pick Health Informatics Consulting to Implement Patient Electronic Health Record Systems 2