Navigation Links
Lithium profoundly prevents brain damage associated with Parkinson's disease
Date:6/23/2011

Lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson's disease (PD) in a mouse model of the condition.

Preclinical research is now underway at the Buck Institute for Research on Aging to determine correct dosages for a drug that continues to be the gold standard for the treatment of bipolar disorder. The Buck is currently working toward initiating a Phase IIa clinical studies of lithium in humans in conjunction with standard PD drug therapy. The research appears in the June 24 online edition of the Journal of Neuroscience Research.

"This is the first time lithium has been tested in an animal model of PD," said lead author and Buck Professor Julie Andersen, PhD. "The fact that lithium's safety profile in humans is well understood greatly reduces trial risk and lowers a significant hurdle to getting it into the clinic."

According to Andersen, lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals. "We fed our mice levels of lithium that were at the low end of the therapeutic range," said Andersen. "The possibility that lithium could be effective in PD patients at subclinical levels is exciting, because it would avoid many side effects associated at the higher dose range." Overuse of lithium has been linked to hyperthyroidism and kidney toxicity.

PD is a progressive, incurable neurodegenerative disorder that affects 1 million Americans and results in tremor, slowness of movement and rigidity. It is the second most common neurodegenerative disease after Alzheimer's. Between 50,000 and 60,000 new cases are diagnosed each year. Age is the largest risk factor for the PD. Onset usually begins between the ages of 45 and 70 years.

Andersen's research focuses on
'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Uncovering lithiums mode of action
2. Lithium may help radiation target cancer, spare healthy tissue
3. Rising greenhouse gases profoundly impact microscopic marine life
4. Enzyme prevents fatal heart condition associated with athletes
5. New research helps explain how progesterone prevents preterm birth
6. New research helps explain how progesterone preventspreterm birth
7. A protein reinforces memory and prevents forgetfulness
8. Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation
9. Essential oil pill prevents PMS
10. Drug prevents post-traumatic stress syndrome
11. The zebrafishs neural circuit prevents it from biting off more than it can chew
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2015)... Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... patent 62114357 for DISTRIBUTED VOICE DIRECTED PAYMENT ... introduces a new groundbreaking payment method. Payment accounts may ... may only be accessed if both the speech (the ...
(Date:2/12/2015)... MINNETONKA, Minn. , Feb. 12, 2015 /PRNewswire/ ... technology company specializing in clinical study management systems, ... Partner Program , further distinguishing iMedNet ... for Clinical Research Organizations (CROs) and healthcare consultants.  ... sales support, prospective customer referrals and numerous co-marketing ...
(Date:2/9/2015)...  Lintec of America recently announced an exclusive license ... macrostructures, including sheets, yarns and ribbons, developed at the ... the vast industrial resources of the global Lintec Group, ... of America is forming the Nano-Science and Technology Center ... on scaling up the manufacturing and commercialization of nano ...
Breaking Biology News(10 mins):NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4
... good news from University of Illinois broccoli researchers this ... broccoli lacks the ability to form sulforaphane, the cancer-fighting ... how the food industry can act to restore the ... that companies can use to make frozen broccoli as ...
... losing about 1.6 million tonnes of carbon per year from ... and carbon accounts, according to new research.,Top soil is rich ... by events such as the ,Red Dawn, in Sydney in ... atmosphere it changes the amount and location of soil carbon. ...
... with carpal tunnel syndrome one of the most common ... research collaboration led by an Arizona State University biomedical engineering ... and Mark Ross were recently awarded a grant of $93,000 ... to quantify the effects of carpal tunnel release surgery on ...
Cached Biology News:Illinois scientists put cancer-fighting power back into frozen broccoli 2Soil carbon 'blowing in the wind' 2ASU-Mayo research project targets carpal tunnel syndrome diagnosis 2
(Date:3/5/2015)... 5, 2015  In response to the incorrect assertions ... FL on February 12, 2015. Impeto Medical ... financial health and their SUDOSCAN® devices have been proven ... Impeto prefers to have the courts decide this dispute ... than 40 articles written by Key Opinion Leaders, published ...
(Date:3/4/2015)... In an article published and posted online ... Security review the clinical aspects of diseases caused by ... The article, "Clinical Management of Potential Bioterrorism-Related Conditions," was ... the New England Journal of Medicine . ... and Tom Inglesby—review the clinical management of conditions resulting ...
(Date:3/4/2015)... 04, 2015 Research and Markets ... the "Global Biologics and Biosimilars Industry Report ... The Global Biologics and Biosimilars Industry ... on the current state of the biologics and ... basic overview of the industry including definitions, classifications, ...
(Date:3/4/2015)... March 4, 2015  BioClinica®, Inc., a ... provider, today announced that clinical trial professionals ... at its annual European User Conference in ... discuss the use of its eClinical technologies ... technologies include: the Microsoft Office-Smart OnPoint CTMS; ...
Breaking Biology Technology:Impeto Medical Responds to Published Allegations by LD Technology LLC ("LD") 2Latest Clinical Information On Bioterrorism Threats 2Global Biologics and Biosimilars Industry Report 2015-2020 2BioClinica Teams With Pharma To Tackle Clinical Trial Challenges In Europe 2BioClinica Teams With Pharma To Tackle Clinical Trial Challenges In Europe 3
... 11 Altogen Biosystems,( http://www.altogen.com ) announced ... Las Vegas, NV, Altogen Custom Services focus ... Interference (RNAi) services, generation of stably-expressing cell,lines, ... the company will draw upon their unique ...
... affordable and accessible to all researchers, HUNTSVILLE, ... that Harvard Medical School and the University of ... Each University,purchased access to whole genome human and ... and distributed by Open Biosystems., (Logo: ...
... China-based R&D and production platform and Datascope,s strong US-based ... direct sales and service network, Provides powerful ... ... SHENZHEN, China, March 11 /Xinhua-PRNewswire-FirstCall/ -- Mindray,Medical International Limited (NYSE: ...
Cached Biology Technology:Altogen Biosystems Launches Custom Biotechnology Research Services: Generation of Stable Cell Lines and RNAi Cell Transfection Services 2Open Biosystems' Open Access RNAi Program Adopted by Harvard Medical School and University of North Carolina 2Mindray to Acquire Datascope's Patient Monitoring Business for US$202 million 2Mindray to Acquire Datascope's Patient Monitoring Business for US$202 million 3Mindray to Acquire Datascope's Patient Monitoring Business for US$202 million 4Mindray to Acquire Datascope's Patient Monitoring Business for US$202 million 5Mindray to Acquire Datascope's Patient Monitoring Business for US$202 million 6
... the data from any one of IITC NIBP ... The final data is sent from the amplifier ... automatic for Systolic, Mean, Heart Rate while the ... always in the position to override the automatic ...
Sirtuin 7 (SIRT7) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: Other Recommended Storage: Long term: -20C; Short term: +4C...
... DNA microarrays designed for your specific applications ... Paraflo microfluidic synthesis platform. Thousands of customer ... LC Sciences can provide assistance with custom ... part of our comprehensive Custom DNA Microarray ...
... microplate sealer with an integrated in-line plate ... a variety of configurations and sealing capabilities. ... stacker and 240-plate storage capacity , Integrated ... small workcells , Handles all SBS microplates ...
Biology Products: