Navigation Links
Lithium may help radiation target cancer, spare healthy tissue
Date:5/4/2009

Vanderbilt-Ingram Cancer Center investigators have uncovered a mechanism that helps explain how lithium, a drug widely used to treat bipolar mood disorder, also protects the brain from damage that occurs during radiation treatments.

In the May 1 issue of the Journal of Clinical Investigation, Fen Xia, M.D., Ph.D., and colleagues show that lithium promotes DNA repair in healthy cells but not in brain tumor cells. The findings suggest that lithium treatment could offer a way to protect healthy brain tissue from damage that may occur during cranial radiation treatments.

Cranial irradiation is part of standard therapy for both primary and metastatic brain tumors. However, as with all treatment modalities, radiation often causes long-term side effects. In particular, neurological impairments including lowered IQ, learning difficulties and memory loss have been reported, especially in children treated for brain cancers. Radiation-induced damage to the healthy cells of the hippocampus, a brain structure crucial for learning and memory, is one likely source of these deficits.

These cognitive impairments have long-lasting effects on the quality of life for survivors, noted Xia, an assistant professor of Radiation Oncology and Cancer Biology.

"Because these patients can now survive longer and are being cured, alleviating long-term toxicity is becoming more important," she said.

Researchers have been searching for agents that could protect healthy brain tissue from radiation-induced damage. Previously, Vanderbilt-Ingram investigators led by Dennis Hallahan, M.D., chair of Radiation Oncology and the Ingram Professor of Cancer Research found that lithium treatment protects cultured hippocampal neurons from radiation-induced cell death and improves cognitive performance in irradiated mice.

But how lithium protects against radiation-induced damage is unclear.

Radiation kills tumor cells by damaging thei
'/>"/>

Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Novel technique changes lymph node biopsy, reduces radiation exposure
2. Could vitamin D save us from radiation?
3. Paradigm Tactical Products to be Largest Distributor of Metal/Radiation Detection Wands in United States
4. NIAID announces 25 new awards to develop radiation countermeasures
5. Checking people at airports -- with terahertz radiation
6. Radiation, nanotechnology, health care and more
7. Experts tackle shipment issues for beneficial radiation sources
8. Distance learning course in radiation oncology for cancer treatment
9. Needle-size device created to track tumors, radiation dose
10. Common aquatic animals show extreme resistance to radiation
11. Predicting the radiation risk to ESAs astronauts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... , April 20, 2015 The ... Glenbeigh Records Management (GRM), Ireland,s ... Dubai Islamic Bank. Having built up an impressive track record ... a leading player within the records management sector in ... to double is GCC staffbase and employ a further eight ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... spent a significant amount of time in an urban setting, the ... suspicious package might be all too familiar. But just how is ... just leftovers or a lethal weapon? The most common way ... so far," says Eric Houser, a program manager in the Explosives ...
... overweight because of my genes," is suddenly gaining credibility ... our bodies digest and process nutrients in the food ... discipline of metabolomics strives to investigate these differences in ... the Technische Universitaet Muenchen are on the front line: ...
... In a discovery that could rewrite the story of ... skeletal remains of a new species of ancient human. The ... latest issue of the prestigious journal Science . The ... found in miners, debris in the Cradle of Humankind World ...
Cached Biology News:Bomb scares: An ODD solution 2Bomb scares: An ODD solution 3Metabolic fingerprints offer fresh clues and a new path toward personalized medicine 2Metabolic fingerprints offer fresh clues and a new path toward personalized medicine 3Scientists uncover new species of human ancestor 2Scientists uncover new species of human ancestor 3
(Date:5/27/2015)... /CNW/ - CQDM, Brain Canada and the Ontario ... (6) multi-disciplinary and multi-provincial research teams across Canada to ... Brain strategic initiative. To this amount, $1.5M is added ... This exciting announcement was made today at the annual ... presence of Inez Jabalpurwala, President and CEO of ...
(Date:5/27/2015)... , May 27, 2015  CytomX, a ... of cancer, today announced the appointments of ... Cynthia Ladd as senior vice president ... was chief financial officer of Onyx Pharmaceuticals, an ... independent consultant and legal counsel to several leading ...
(Date:5/27/2015)... -- US-Australian drug discovery and development company, Novogen Limited (ASX: NRT; ... at the Brain Tumor Biotech Summit 2015, being held in ... The venue is the Lennox Hill Hospital, East 76 th ... The Brain Tumor Biotech Summit brings together the nation,s top ... community to promote innovative new therapies for brain tumors.  ...
(Date:5/26/2015)... 26, 2015 The University of ... Max Planck Society establishing the Max Planck-University ... center will link two of the world's foremost research ... only the third Max Planck Centre in North America. ... for optics and photonics, was with university and ...
Breaking Biology Technology:Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10CytomX Expands Executive Leadership Team 2CytomX Expands Executive Leadership Team 3Novogen to Present at Brain Tumor Biotech Summit 2015 2Novogen to Present at Brain Tumor Biotech Summit 2015 3Novogen to Present at Brain Tumor Biotech Summit 2015 4Novogen to Present at Brain Tumor Biotech Summit 2015 5Third Max Planck Centre in North America Inaugurated at University of Ottawa 2Third Max Planck Centre in North America Inaugurated at University of Ottawa 3
... -- The president of Cars.com and one ... and other Internet topics in the Sept. 29 inaugural speaker ... , ,The speaker, Mitch Golub, has an extensive background in ... joined Classified Ventures, which includes Cars.com, after a 21-year career ...
... Madison, Wis. - An improved warning system could ... representatives of a Madison company involved in emergency communications. ... the levees were breached, where people could have been ... said Kendall Post, chief technology officer of Madison-based ...
... Inc., has launched interactive, personalized services for Milwaukee ... the company announced Thursday. Traffic.com will provide area ... displays of roadway traffic conditions including congestion levels, ... in a news release. , ,Data for the ...
Cached Biology Technology:Cars.com president slated for Milwaukee event 2Madison company urges disaster warning upgrades 2
... PGE1-d4 contains 4 deuterium atoms at the ... is intended for use as an internal ... GC- or LC-mass spectrometry. PGE1 is the ... but it is virtually undetectable in the ...
Assay Diluent, 10 L...
Direct ELISA Assay Diluent - EDTA, 10 L...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: