Navigation Links
Liquid glucagon formulation discovered for potential use in artificial pancreas systems
Date:6/12/2012

er both insulin and glucagon, or other drugs.

Glucagon is a naturally occurring hormone that responds to hypoglycemia (extreme low blood sugar) by raising blood sugars, but its regulation is impaired in people with T1D. It works to complement the function of insulin to provide the natural fine-tuning of blood glucose control. Previous studies have shown that the addition of glucagon to insulin treatment reduces the frequency of hypoglycemia in T1D, more closely mimicking the physiology of someone without diabetes.

Commercially available glucagon does not maintain its liquid form after the powder and solution are combined, making it suitable only for immediate use. Dr. Ward and his team found that raising the pH of the glucagon allowed the hormone to maintain liquid form, and concluded that this formulation could be suitable for use in a closed-loop bi-hormonal pump.

"We have seen very promising results in our studies of artificial pancreas systems that utilize both insulin and glucagon. But for people with diabetes to realize this potential benefit, we need glucagon that is stable and can be used in a pump," said Sanjoy Dutta, Ph.D., JDRF's senior director of treat therapies. "Dr. Ward's research is promising and steers us toward more tangible solutions along the path toward a multi-hormonal, fully-automated closed loop artificial pancreas."

The artificial pancreas combines a continuous glucose monitor (CGM) and an insulin pump via sophisticated computer software, to provide the right amount of insulin at the right times for people with diabetes. In March, the U.S. Food and Drug Administration approved the first artificial pancreas outpatient trial in the United States. Researchers envision future generations of the device to automatically deliver more than one hormone, in addition to insulin, to more closely perform the functions of a non-diabetic human pancreas.


'/>"/>

Contact: William Sorensen
wsorensen@jdrf.org
212-479-7558
JDRF
Source:Eurekalert

Page: 1 2

Related biology news :

1. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
2. Microbe that can handle ionic liquids
3. Reduced glycerin formulation of tenofovir vaginal gel safe for rectal use
4. Unexpected crustacean diversity discovered in northern freshwater ecosystems
5. University of Alberta led research may have discovered how memories are encoded in our brains
6. Newly discovered foot points to a new kid on the hominin block
7. New immune defense enzyme discovered
8. New genetic mechanism of immune deficiency discovered
9. Housekeeping mechanism for brain stem cells discovered
10. Scientists have discovered genes that increase the risk of osteoporosis and fractures
11. New form of intellectual disability discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 1 can inhibit voltage-gated calcium channel, decrease ... However, some scholars demonstrated that cannabinoid receptor ... and increase neurotransmitter release. Dr. Yi Zhang ... Tongji Medical College, Huazhong University of Science ... and calcium imaging in cultured trigeminal ganglion ...
(Date:7/11/2014)... proteins that let nerve cells send out electrical signals, ... biological tactic that may offer a new way to ... environmentally responsible way. , Their findingthat naturally occurring ... harmless for a closely related onesuggests that insecticides can ... species like bees. A summary of the research, led ...
(Date:7/10/2014)... cities in New Mexico, nearly every public golf course ... precious potable water supplies. Across the U.S. Southwest as ... receive treated effluent. Reusing the effluent increases the sustainability ... homeowners alike fertilize their lawns during the growing season. ... Mexico State University turfgrass expert has a new vision ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3'Tailored' water -- the latest in lawn care 2
... and the Council for Advancement and Support of Education ... 2010 Arizona Professor of the Year. Maienschein, a Regents, ... Life Sciences, was selected from more than 300 top ... team sport," Maienschein says, with credit to colleagues and ...
... When it comes to teaching space and Earth sciences, ... State University researchers are helping K-12 teachers to bring it ... (IGES) has awarded a $37,500 grant to professors Paul Ruscher ... them to design and enhance a series of courses to ...
... the Anaktuvuk River Fire burned more than 1,000 square kilometers ... in that region since record keeping began in 1950. ... area revealed that this was the most destructive tundra fire ... on 60 years of climate and fire data found that ...
Cached Biology News:ASU professor named top in state of Arizona 2ASU professor named top in state of Arizona 3FSU researchers helping K-12 teachers bring science down to Earth 2As Arctic temperatures rise, tundra fires increase, researchers find 2
(Date:7/10/2014)... Burkina Faso (PRWEB) July 10, 2014 ... Faso, today have access to an additional family ... increase access to contraception at all levels of ... a lower-dose formulation of a widely used contraceptive—Pfizer’s ... system. , Burkina Faso is the first of ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, ... announce the relaunch of his highly informative blog, now named ... “ What are Stem Cells ?” Dr. Harman’s purpose ... in the basics of stem cell therapy so that pet ... of treatment when considering regenerative medicine. , A veterinarian by ...
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... Mass., Jan. 12 Microbia Precision Engineering,Inc. (Microbia) ... the,company as Director of North American Sales. In ... for developing and maintaining business,accounts and building customer ... "Chuck Walton is a highly experienced veteran ...
... American Oriental,Bioengineering, Inc. (NYSE: AOB ) ... manufacturer of pharmaceutical and healthcare products in,China, today ... one-on-one,meetings at the 2009 UBS Greater China Conference, ... Management is currently scheduled to meet with,institutional investors ...
... 12 Singulex, Inc. today announced that it has ... Co., Ltd. and supported by existing investors including OrbiMed ... the commercialization of Singulex technologies in the diagnostics market. ... for JAFCO Life Science Investment, will join the company,s ...
Cached Biology Technology:Microbia PE Adds Nutritional Ingredient Industry Veteran Charles Walton to Senior Management Team 2Singulex Closes $19 Million Financing Round 2
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
NORMAL DONOR DONKEY SERUM...
... Molecular Probes Fc OxyBURST Green reagent (F-2902) ... of Boston University to permit measurement of ... and the subsequent oxidative burst directly in ... reagent consists of bovine serum albumin (BSA) ...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: