Navigation Links
Liquid glucagon formulation discovered for potential use in artificial pancreas systems
Date:6/12/2012

New York, NY, June 12, 2012JDRF-funded researchers at Oregon Health & Science University (OHSU) and Legacy Health have discovered a liquid glucagon formulation that may be useable in standard diabetes pumps. Such a formulation could broaden the use of glucagon to help prevent hypoglycemia in people with type 1 diabetes (T1D) who are treated with insulin. It could also open a path to future-generation artificial pancreas systems that dispense more than just insulin for optimizing glucose control.

"Our previous studies have shown that the injections of small amounts of glucagon prevent hypoglycemia, which is a frequent and serious complication of type 1 diabetes that can lead to seizures, loss of consciousness, and even death," said W. Kenneth Ward, M.D., associate professor of medicine (endocrinology, diabetes, and clinical nutrition) at OHSU School of Medicine and senior scientist at Legacy Health, the two Portland, OR-based organizations that collaborated on the study. The research was presented at the American Diabetes Association's (ADA) 72nd Scientific Sessions on Friday, June 8, and on Sunday, June 10, in Philadelphia.

Dr. Ward continues: "Current forms of glucagon cannot be kept for long periods of time in a portable pump, and therefore could not be used as part of an artificial pancreas system. While it is important to note that additional studies will be undertaken in animals and humans before FDA approval can be sought, we have found that the alkaline glucagon compound we discovered can be kept in liquid form for long periods of time, potentially opening pathways for use in bi-hormonal diabetes pumps and toward better therapies for people with diabetes."

The research is a key step forward toward the routine delivery of glucagon for people with T1D, and toward the development of a multi-hormonal, fully-automated closed loop artificial pancreas system. Such future-generation artificial pancreas systems would automatically deliver both insulin and glucagon, or other drugs.

Glucagon is a naturally occurring hormone that responds to hypoglycemia (extreme low blood sugar) by raising blood sugars, but its regulation is impaired in people with T1D. It works to complement the function of insulin to provide the natural fine-tuning of blood glucose control. Previous studies have shown that the addition of glucagon to insulin treatment reduces the frequency of hypoglycemia in T1D, more closely mimicking the physiology of someone without diabetes.

Commercially available glucagon does not maintain its liquid form after the powder and solution are combined, making it suitable only for immediate use. Dr. Ward and his team found that raising the pH of the glucagon allowed the hormone to maintain liquid form, and concluded that this formulation could be suitable for use in a closed-loop bi-hormonal pump.

"We have seen very promising results in our studies of artificial pancreas systems that utilize both insulin and glucagon. But for people with diabetes to realize this potential benefit, we need glucagon that is stable and can be used in a pump," said Sanjoy Dutta, Ph.D., JDRF's senior director of treat therapies. "Dr. Ward's research is promising and steers us toward more tangible solutions along the path toward a multi-hormonal, fully-automated closed loop artificial pancreas."

The artificial pancreas combines a continuous glucose monitor (CGM) and an insulin pump via sophisticated computer software, to provide the right amount of insulin at the right times for people with diabetes. In March, the U.S. Food and Drug Administration approved the first artificial pancreas outpatient trial in the United States. Researchers envision future generations of the device to automatically deliver more than one hormone, in addition to insulin, to more closely perform the functions of a non-diabetic human pancreas.


'/>"/>

Contact: William Sorensen
wsorensen@jdrf.org
212-479-7558
JDRF
Source:Eurekalert

Related biology news :

1. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
2. Microbe that can handle ionic liquids
3. Reduced glycerin formulation of tenofovir vaginal gel safe for rectal use
4. Unexpected crustacean diversity discovered in northern freshwater ecosystems
5. University of Alberta led research may have discovered how memories are encoded in our brains
6. Newly discovered foot points to a new kid on the hominin block
7. New immune defense enzyme discovered
8. New genetic mechanism of immune deficiency discovered
9. Housekeeping mechanism for brain stem cells discovered
10. Scientists have discovered genes that increase the risk of osteoporosis and fractures
11. New form of intellectual disability discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader ... “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, ... providing practical tips, tools, and strategies for clinical researchers. , “The landscape of ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
Breaking Biology Technology: