Navigation Links
Liquid glucagon formulation discovered for potential use in artificial pancreas systems
Date:6/12/2012

New York, NY, June 12, 2012JDRF-funded researchers at Oregon Health & Science University (OHSU) and Legacy Health have discovered a liquid glucagon formulation that may be useable in standard diabetes pumps. Such a formulation could broaden the use of glucagon to help prevent hypoglycemia in people with type 1 diabetes (T1D) who are treated with insulin. It could also open a path to future-generation artificial pancreas systems that dispense more than just insulin for optimizing glucose control.

"Our previous studies have shown that the injections of small amounts of glucagon prevent hypoglycemia, which is a frequent and serious complication of type 1 diabetes that can lead to seizures, loss of consciousness, and even death," said W. Kenneth Ward, M.D., associate professor of medicine (endocrinology, diabetes, and clinical nutrition) at OHSU School of Medicine and senior scientist at Legacy Health, the two Portland, OR-based organizations that collaborated on the study. The research was presented at the American Diabetes Association's (ADA) 72nd Scientific Sessions on Friday, June 8, and on Sunday, June 10, in Philadelphia.

Dr. Ward continues: "Current forms of glucagon cannot be kept for long periods of time in a portable pump, and therefore could not be used as part of an artificial pancreas system. While it is important to note that additional studies will be undertaken in animals and humans before FDA approval can be sought, we have found that the alkaline glucagon compound we discovered can be kept in liquid form for long periods of time, potentially opening pathways for use in bi-hormonal diabetes pumps and toward better therapies for people with diabetes."

The research is a key step forward toward the routine delivery of glucagon for people with T1D, and toward the development of a multi-hormonal, fully-automated closed loop artificial pancreas system. Such future-generation artificial pancreas systems would automatically deliv
'/>"/>

Contact: William Sorensen
wsorensen@jdrf.org
212-479-7558
JDRF
Source:Eurekalert

Page: 1 2

Related biology news :

1. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
2. Microbe that can handle ionic liquids
3. Reduced glycerin formulation of tenofovir vaginal gel safe for rectal use
4. Unexpected crustacean diversity discovered in northern freshwater ecosystems
5. University of Alberta led research may have discovered how memories are encoded in our brains
6. Newly discovered foot points to a new kid on the hominin block
7. New immune defense enzyme discovered
8. New genetic mechanism of immune deficiency discovered
9. Housekeeping mechanism for brain stem cells discovered
10. Scientists have discovered genes that increase the risk of osteoporosis and fractures
11. New form of intellectual disability discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... -- Forensicon, Inc., a Chicago -based digital ... promotion of Yaniv Schiff from Senior Computer ... new role as Director, he will lead company efforts ... and provide leadership within the company,s digital forensics practice ... Schiff joined Forensicon in 2006 and ...
(Date:11/7/2014)... -- In conjunction with the Glendale and ... of the Verdugos has announced the " GLENDALE ... initiative to keep the Verdugo Regional Crime Lab operational after ... of existence, the Lab has processed more than 400 DNA ... "Because our number one priority is the wellbeing ...
(Date:11/6/2014)... cancer deaths occur because of metastasis, yet progress ... been slow. , "It,s been particularly challenging to ... Gujral, research fellow in systems biology at Harvard ... detected until after they,ve already metastasized." , Gujral ... that should help researchers better understand how metastasis ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3
... of cell and developmental biology, has been awarded one ... Awards, one of the NIH,s most prestigious grants. ... address a significant medical science challenge: identifying the full ... and disease processes such as cancer. Major, a ...
... professors have been named 2010 fellows of the American ... and Interdisciplinary Studies (CBIS) and the Howard P. Isermann ... and Professor Emeritus of Chemistry Leonard Interrante were both ... and contributions to the science, the profession, and service ...
... parts of the world have brought into sharp focus new ... of rivers during periods of high flow. Using an ... how the flow of river water affects the movement of ... changes in the bed of an artificial water channel to ...
Cached Biology News:UNC scientist receives NIH director's New Innovator Award 2Rensselaer professors Dordick and Interrante named ACS Fellows 2What lies beneath: Study examines sediment movement during floods in rivers 2What lies beneath: Study examines sediment movement during floods in rivers 3
(Date:11/24/2014)... Nov. 24, 2014  Last week, Representatives ... (D-NC) took a bold bipartisan step on ... the OPEN Act. Original co-sponsors of the legislation ... Act will incentivize drug makers and innovators to ... and pediatric cancers, which opens the door to ...
(Date:11/24/2014)... 2014 Continental Clinical Solutions, LLC ... clinical trials at its mid-Atlantic late-phase research facility, ... created with the idea of closing patient disparities ... in medical advances," said Continental's CEO, Saleh ... the immortal cell line of Henrietta Lacks, dubious ...
(Date:11/23/2014)... Apiscent Labs, a privately held ... ingredients to the global pharmaceutical and flavor & ... website, Apiscent.com. , The Apiscent.com homepage welcomes visitors ... easy navigation, rotating images and content focused on ... , The company’s work in Pharmaceutical ...
(Date:11/22/2014)... MD (PRWEB) November 21, 2014 ... management solutions provider, has released Limfinity® version 5.1.4. ... installation projects of Limfinity® than ever in RURO’s ... configuration and minority framework enhancement. Limfinity® version 5.1.4 ... far above and beyond bug fixes! , Limfinity® ...
Breaking Biology Technology:OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3RURO Announces Limfinity® version 5.1.4 2
... even the resources of the world,s largest industrialized nations, scientists ... to find solutions. , Mark Shannon of the University of ... water resource research to address this crisis in a review ... "As dire as the growing problems are with a lack ...
... Blacksburg, Va. -- The ubiquity of mineral nanoparticles in ... intriguing properties provide Earth scientists with another dimension in ... team of scientists from seven universities in a review ... Nanominerals, Mineral Nanoparticles, and Earth Chemistry. , The way ...
... March 20 Scientists at the,Bio-Communications Research ... for,the Improvement of Human Functioning International (CIHFI), ... about its recent stem cell,discovery. The scientific ... stem cell population" received BioMed Central,s,Research Article ...
Cached Biology Technology:Countering an approaching water crisis 2Nanoscience will change the way we think about the world 2Nanoscience will change the way we think about the world 3Nanoscience will change the way we think about the world 4Nanoscience will change the way we think about the world 5Medical Research Award Goes to Adult Stem Cell Scientists at a Kansas Not-for-Profit Organization 2
The F40 piston assembly is supplied as two assemblies to service one F40 pump of a BioLogic DuoFlow workstation....
Mouse monoclonal antibody raised against a full length recombinant ATF3. NCBI Entrez Gene ID = ATF3...
... is used as an internal standard for ... dilution mass spectrometry. 5-OxoETE is a polyunsaturated ... 5-HETE in human neutrophils. It stimulates cytosolic ... of 2 nM. 5-OxoETE selectively stimulates the ...
BD BioCoat Osteologic Coverslips that have been sterilized by ETO gas. Coating : Osteologic&trade ,Thickness : 0.16 mm ,Diameter : 12.7 mm ,Gridded : No ...
Biology Products: