Navigation Links
Liquid biopsy could improve cancer diagnosis and treatment
Date:9/30/2013

ANN ARBORA microfluidic chip developed at the University of Michigan is among the best at capturing elusive circulating tumor cells from bloodand it can support the cells' growth for further analysis.

The device, believed to be the first to pair these functions, uses the advanced electronics material graphene oxide. In clinics, such a device could one day help doctors diagnose cancers, give more accurate prognoses and test treatment options on cultured cells without subjecting patients to traditional biopsies.

"If we can get these technologies to work, it will advance new cancer drugs and revolutionize the treatment of cancer patients," said Dr. Max Wicha, director of the U-M Cancer Center and co-author of a paper on the new device, published online this week in Nature Nanotechnology.

"Circulating tumor cells will play a significant role in the early diagnosis of cancer and to help us understand if treatments are working in our cancer patients by serving as a 'liquid' biopsy to assess treatment responses in real time," said co-author Dr. Diane Simeone, the Lazar J. Greenfield Professor of Surgery at the U-M Medical School and director of the Translational Oncology Program.

"Studies of circulating tumor cells will also help us understand the basic biologic mechanisms by which cancer cells metastasize or spread to distant organsthe major cause of death in cancer patients."

Yet these cells aren't living up to their promise in medicine because they are so difficult to separate from a blood sample, the researchers say. In the blood of early-stage cancer patients, they account for less than one in every billion cells, so catching them is tougher than finding the proverbial needle in a haystack.

"I can burn the haystack or use a huge magnet," said Sunitha Nagrath, an assistant professor of chemical engineering, who led the research. "When it comes to circulating tumor cells, they almost look likefeel lik
'/>"/>

Contact: Kate McAlpine
kmca@umich.edu
734-763-4386
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Flow restrictors may reduce young childrens accidental ingestion of liquid medications
2. Ionic liquid breakthrough in thermal electrical energy
3. Wayne State University researchers techniques enable more, faster testing of biological liquids
4. NREL to help convert methane to liquid diesel
5. Morphing DNA hydrogel flows like liquid but remembers its original shape
6. Faster, cheaper gas and liquid separation using custom designed and built mesoscopic structures
7. Liquid glucagon formulation discovered for potential use in artificial pancreas systems
8. Microbe that can handle ionic liquids
9. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
10. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
11. European law could be unbearable for Croatias brown bears
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... yet progress in preventing and treating migratory cancer ... challenging to design drugs that work against metastasis," ... at Harvard Medical School. , "Unfortunately, many ... , Gujral and colleagues have now identified a ... how metastasis begins. Their findings may also inform ...
(Date:11/6/2014)... MD, November 6, 2014 - Insilico Medicine, Inc, ... aging and age related diseases announced a research ... of cancer, Champions Oncology, Inc (OTC: CSBR). , ... for personalized medicine, but Champions Oncology,s TumorGraft technology ... validate the chemotherapy regimen experimentally generating vast amounts ...
(Date:11/5/2014)... RENO – Kelly Redmond has dedicated his career ... knowledge to a general audience. , As deputy ... Climate Center at Nevada,s Desert Research Institute, Redmond ... the management, application and dissemination of climate data ... Annual Fall Meeting in San Francisco on December ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... relocation of an Inuit village already underway, some 400 ... in Alaska for a UN-affiliated conference April 20-24 to ... to both mitigate and adapt to climate change. ... Global Summit on Climate Change is also designed to ...
... Biology 2009 meeting in New Orleans, Dr. Kristine ... Control Technologies Branch of the Health Effects Laboratory ... results from the first study to directly link ... with exposure to different vibration frequencies with biological ...
... grew warmer from 18,700 to 10,000 years ago, juniper trees ... of their favorite food. Now, University of Utah biologists have ... eat toxic creosote bushes that replaced juniper. "It was ... Dearing, senior author of the study, published online Tuesday, April ...
Cached Biology News:Indigenous peoples at world summit to share climate change observations, coping techniques 2Indigenous peoples at world summit to share climate change observations, coping techniques 3Indigenous peoples at world summit to share climate change observations, coping techniques 4Indigenous peoples at world summit to share climate change observations, coping techniques 5Indigenous peoples at world summit to share climate change observations, coping techniques 6Risk of vibration-induced vascular injuries linked to vibration frequency differences 2Poison: It's what's for dinner 2Poison: It's what's for dinner 3Poison: It's what's for dinner 4Poison: It's what's for dinner 5
(Date:11/26/2014)... -- The announced sales of three healthcare units within ... expand in non-healthcare areas, says Kalorama Information. Siemens hasn,t ... says that  Siemens is the third largest company in ... IVD market , with 5.5 billion in IVD revenues ... likely affect IVD market shares.  Siemens ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 The ... City’s award-winning technology innovation centers, announced today that ... closing on December 1st. “Do you have a ... so, I want to know about it. AccelerateBaltimore ... idea to product in just 13 weeks.” ...
(Date:11/26/2014)... Sunnyvale, CA (PRWEB) November 25, 2014 ... joins forces with RPM Alliance , provider ... and pharmaceutical companies. With the latest addition to its ... only free validated EDC system to India. , ... as a robust and customizable EDC platform which is ...
(Date:11/26/2014)... OH (PRWEB) November 25, 2014 Miles ... has joined the Graphel Carbon Products team as Sales/Marketing ... sales, marketing, and customer service for the graphite industry. ... Miles to our team,” stated Dave Trinkley, VP of ... “His wide range of experience in the graphite industry, ...
Breaking Biology Technology:Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2
... have united to build the largest quantum key distribution ... and industrial organisations were realised as secure, quantum encrypted ... With an average link length of 20 to ... the researchers from organisations such as the AIT Austrian ...
... July 2 Lixte Biotechnology Holdings (OTC Bulletin Board: ... of Neurological Disorders and Stroke (NINDS) and the National ... reported that its novel compound, LB-1.2, enhances the effectiveness ... human cancers. This research is being conducted under a ...
... A tiny grid pattern has led materials scientists at ... the Institute of Solid State Physics in Russia to ... certain electromagnetic nanostructures used in data storage. Their recently ... design and manufacture of future ultra-high density data storage ...
Cached Biology Technology:Researchers unite to distribute quantum keys 2Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models 2Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models 3Unexpectedly long-range effects in advanced magnetic devices 2
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z35,347-7) or contact ...
Standard Fluka For microscopy (Bact., Hist.)...
Certified by the Biological Stain Commission. For staining fresh peripheral blood smears and blood parasites....
... Freedom EVO384R are fast multi-channel pipetting platforms ... different sizes, with a multi-channel head and ... time saving, with true parallel processing of ... your assays with the Freedom EVOware program. ...
Biology Products: