Navigation Links
Lipids in the brain an important factor for Alzheimer's disease?
Date:12/10/2007

Brussels & Leuven, Belgium As the most common form of dementia in the Western world, Alzheimer's disease carries enormous implications for our ageing society. It is generally accepted that the disease is caused by Alzheimer peptide (A -peptide) protofibrils. Until now, the conditions under which this type of protofibril is formed and leads to the disease remained unknown. VIB researchers have now discovered that certain lipids, present also in our brains, promote the formation of this protofibril. This discovery is of major importance because it opens up new avenues of research into finding medicines against Alzheimer's disease. It also explains earlier indications of a link between lipids and Alzheimer's disease.

Misfolded proteins: cause of various diseases

The biological functioning of cells depends on the right folding of thousands of proteins. Normally, cells automatically correct misfolded proteins. In diseases such as Alzheimers, Parkinson's and Creutzfeld-Jacob's, however, misfolded proteins are deposited in the body's tissues. In Alzheimer's disease the most common form of dementia, which in Belgium alone affects about 100,000 people misfolding of the A -amyloid peptide leads in various stages to the formation of plaques. These plaques consist of accumulations of so-called fibrils and is not in itself toxic. One of the intermediary stages in the formation of plaques is the formation of the protofibril form of the A -peptide. Protofibrils are toxic for brain cells, causing the poisoned cells to die off and leading to memory loss. This is why these protofibrils are considered to be the main cause of the symptoms of Alzheimer's disease.

Surrounding brain lipids destabilize plaques

VIB researchers were able, using certain lipids, to convert the fibrils into protofibrils. This came as a surprise, for it had long been assumed that the fibrils and the plaque they cause are stable and that once they have
'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists get grip on slippery lipids
2. Invasion of the brain tumors
3. HIV is a double hit to the brain
4. AIDS interferes with stem cells in the brain
5. 60 second test could help early diagnosis of common brain diseases
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Inside the brain of a crayfish
10. Specific brain protein required for nerve cell connections to form and function
11. Brains timing linked with timescales of the natural visual world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/11/2014)... treatise "Flora of Northumberland and Durham" by Nathaniel ... Books platform as an example of combining modern ... new sort of resource and data re-use. This publication ... the region, which can be seen as a model ... enriched re-publication marries the meticulous detail of old ...
(Date:9/11/2014)... Northeastern University researchers and their international colleagues have ... role of neutral evolution in the biogeographic distribution ... Thursday in the journal Science . The ... a neutral agent-based model"was co-authored by Ferdi Hellweger, ... of civil and environmental engineering; his doctoral student ...
(Date:9/11/2014)... -- Today at the TEDMED conference, Tute Genomics announced ... genome sequencing results at the fingertips of the individual ... The $1000 was announced earlier this year by Illumina, ... point towards widespread adoption of genome sequencing in research ... million variants per human genome, data analysis has become ...
Breaking Biology News(10 mins):Re-publication of 'Flora of Northumberland and Durham' (1831): A dramatic account of change 2Re-publication of 'Flora of Northumberland and Durham' (1831): A dramatic account of change 3Microbes evolve faster than ocean can disperse them 2Tute Genomics Launches MyGene Portal for Genome-guided Medicine 2Tute Genomics Launches MyGene Portal for Genome-guided Medicine 3
... Jan. 26, 2011 TGen Drug Development (TD2) ... should help speed new drugs safely into human testing ... Scottsdale, Ariz., provides drug development firms with expertise in ... regulatory approval steps of getting new drugs to patients ...
... ribbon worm discovered in Kosterhavet National Park in 2007 ... Pseudomicrura afzelii , a form of nemertean or ... at the University of Gothenburg, Sweden, using DNA technology. ... from the traditional, highly labour-intensive way of describing a ...
... 25, 2011Give caffeine to cells engineered to produce viruses used ... 8-times more virus, according to a paper published in ... Ann Liebert, Inc. ( www.liebertpub.com ). The paper is available ... inexpensive strategy for increasing lentivirus production was developed by Brian ...
Cached Biology News:Arizona companies team up, providing quick development of cancer drugs 2Researchers register new species using DNA-based description 2
(Date:9/11/2014)... 11, 2014 Central Florida board-certified veterinary ... partnerships with several Brevard County animal hospitals to bring ... been working in the area since January 2006, credentialed ... 2008, and is happy to now offer his expertise ... Christiansen has used stem cell therapy with Vet-Stem, Inc. ...
(Date:9/11/2014)... The Remedy Group , a retained ... organizations, has announced that Terry Souwannamuang has joined the ... in biopharma and managed care Terry steadily rose in ... brand new specialty pharmacy for a Portland-based managed care ... Terry has a Bachelor’s Degree in General Science with ...
(Date:9/10/2014)... BASEL , Schweiz, September 11, 2014 ... Register für Eierstockkrebs, die bei der Jahresversammlung ... vorgestellt wurden, bekräftigen die komplette Tumorprofilierung als ... Bericht von Caris Registry™ zeigte ein deutlich ... mit Eierstock-, Eileiter- oder primär peritonealem Krebs, ...
(Date:9/10/2014)... -- Orexigen® Therapeutics, Inc. (Nasdaq: OREX ), a ... host a conference call and webcast tomorrow, September 11, ... time). The live call may be accessed ... participant code 38075452. The webcast can be accessed live ... site at www.orexigen.com and will be archived ...
Breaking Biology Technology:Dr. Jeff Christiansen is Now Offering Stem Cell Therapy for Pets at Five Brevard County Animal Hospitals and Beyond 2Dr. Jeff Christiansen is Now Offering Stem Cell Therapy for Pets at Five Brevard County Animal Hospitals and Beyond 3The Remedy Group Announces Hiring of Managed Care and Specialty Pharmacy Veteran 2Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 2Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 3Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 4Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 5
... biomass and enzymes to produce hydrogen fuel, ethanol, and ... AgVest in Lake Delton last Thursday. , ,These ... the conference by the AgVest group, which focuses on ... specific recommendations, AgVest tries to hook up up-and-coming agricultural ...
... a PeopleSoft database for tracking alumni in favor ... used for 12 years. , ,Schools and colleges can access ... based on a database from 4D, Inc. , ... separate from the university. When the central database failed to ...
... has been less than overwhelming to Governor Jim Doyles ... private money in Wisconsins biotechnology future. Budget-conscious members of ... of stem-cell research have once again protested, and Milwaukee ... of Madison. , ,Doyle should address all legitimate gripes ...
Cached Biology Technology:Investors hear about new agricultural technology 2Alumni Association extends database help to university 2Alumni Association extends database help to university 3Wisconsin cannot afford to take a pass on Doyles biotech plan 2Wisconsin cannot afford to take a pass on Doyles biotech plan 3
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
NORMAL DONOR DONKEY SERUM...
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
Biology Products: