Navigation Links
Lipid peroxides -- more sophisticated than their reputation
Date:8/24/2010

This release is available in German.

In a joint study conducted by Helmholtz Zentrum Mnchen, the German Center for Neurodegenerative Diseases (DZNE) and a research group at Karolinska Institutet in Stockholm, Sweden, researchers have now discovered that lipid peroxides* play a specific physiological role in the cell. Prior to this study, scientists had already established that accumulation of lipid peroxides* indicate cell stress. Lipid peroxides have further been shown to be very potent inducers of cell death. The results of this study now demonstrate that chemically modified (oxidized) lipids temporarily inactivate protein tyrosine phosphatases*. These in turn regulate the cellular communication of receptor tyrosine kinases (RTK)*. This finding is of central importance because aberrant activation of the receptor tyrosine kinases contributes to many diseases, including cancer. Until now, only hydrogen peroxide was known to oxidize and inactivate protein tyrosine phosphatases and thus to have a regulating effect on kinases.

"We were able to show that lipid peroxides are 100-1000 times more effective than hydrogen peroxide," said Dr. Marcus Conrad, lead authors of the publication, who has since moved from Helmholtz Zentrum Mnchen to the German Center for Neurodegenerative Disease. Dr. Arne stman and sa Sandin from the Karolinska Institutet added: "It will be very interesting to see if lipid peroxides contribute to the activation of tyrosine kinases in cancer and other diseases, e.g. diabetes and Alzheimer's disease."

*Background

Lipid peroxides are chemically modified lipids or fatty acids, which, among other things, indicate cellular stress. In high concentrations they can trigger cell death. Elevated concentrations of lipid peroxides are often found in patients with common diseases such as atherosclerosis, diabetes, cancer or neurodegenerative diseases including Parkinson's and Alzheimer's disease.

Receptor tyrosine kinases (RTK) and protein tyrosine phosphatases have an important function in the regulation of cell growth and division. Over-active receptor tyrosine kinases play a key role in the etiology of cancer. A frequent cause of breast cancer, for instance, is a malfunction of the receptor tyrosine kinase HER-2 (human epidermal growth factor receptor 2). In healthy tissues and cells receptor tyrosine kinases are precisely regulated by protein tyrosine phosphatases.


'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
49-089-318-73946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related biology news :

1. The genetic heart of the lipids
2. Lipid droplets lead a Spartin existence
3. Boston University School of Medicine researcher awarded the 2010 Avanti Award in Lipids
4. Research reveals lipids unexpected role in triggering death of brain cells
5. Genetic causes identified for disturbances in lipid metabolism
6. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
7. CHEO RI study uses sophisticated genetic engineering to improve insulin-producing beta cells
8. Women do not recover their muscle strength as fast as men
9. Beetles get by with a little help from their friends
10. Migratory moths may hitch their rides, but theyre anything but drifters
11. IOF calls on European citizens to stand tall and speak out for their bones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the Pennsylvania Convention Center and will showcase its product’s latest features from June ... be presenting a scientific poster on Disrupting Clinical Trials in The Cloud during ...
(Date:6/23/2016)...  Amgen (NASDAQ: AMGN ) today announced ... life sciences incubator to accelerate the development of new ... at QB3@953 was created to help high-potential life science ... early stage organizations - access to laboratory infrastructure. ... two "Amgen Golden Ticket" awards, providing each winner with ...
Breaking Biology Technology: