Navigation Links
Lipid droplets lead a Spartin existence
Date:3/23/2009

Spartin, a protein linked to the neuronal disease Troyer syndrome, was thought to function in endocytosis. In the March 23, 2009 issue of the Journal of Cell Biology (www.jcb.org), Eastman et al. identify an unexpected role for Spartin in regulating the cell's lipid storage depots.

Cells transport excess fats into lipid droplets (LDs), where they are kept until needed as sources of energy, but little is known about LD formation and regulation. Spartin hadn't been connected to LDs. But Eastman et al. found that Spartin localizes to LDs and binds to a known LD protein called TIP47.

Spartin seems to regulate LD turnover: overexpressing or knocking-down the protein caused an increase in both the organelle's size and number. In turn, Spartin is regulated by ubiquitination by the ubiquitin ligase WWP1. Overexpressed WWP1 removed Spartin from LDs and promoted its degradation.

A truncated form of Spartin found in a rare neuronal disease called Troyer syndrome didn't localize to LDs or bind to TIP47. It remains to be seen whether defects in LD function are the root cause of the defects seen in Troyer patients, but author Paul Bieniasz points to precedents of defects in lipid turnover triggering neuronal disorders, such as mutations in the phospholipase NTE causing motor neuron disease.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. Chemists get grip on slippery lipids
3. Powerful integration of lipid metabolic profiling with gene expression analysis
4. Story ideas from the Journal of Lipid Research
5. Lipids in the brain an important factor for Alzheimers disease?
6. Story ideas from the Journal of Lipid Research
7. New genetic variants associated with lipid levels, risk for coronary artery disease
8. Europe-wide investment in lipid research will help tackle disease, says new report
9. People with heart disease still have trouble controlling blood lipid levels
10. The genetic heart of the lipids
11. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lipid droplets lead a Spartin existence
(Date:4/17/2014)... Razzari of the nergie Matriaux Tlcommunications Research Centre ... John R. Evans Leaders Fund of the Canada ... state-of-the-art biotech and nanophotonics equipment. To this funding ... de l,Enseignement suprieur, de la Recherche, de la ... laboratories will help us develop new approaches for ...
(Date:4/17/2014)... Kansas State University engineer has developed a patented ... improvised explosive devices. The same technique could help ... Steven M. and Kay L. Theede chair in ... engineering, and his research team have created a ... in car trunks. The distance detection method ...
(Date:4/17/2014)... This news release is available in German . ... fails to pay the protection money demanded of him, he ... are seldom required, however, as fear of the consequences is ... is observed in parasitic birds, which lay their eggs in ... egg out, the brood parasites take their revenge by destroying ...
Breaking Biology News(10 mins):New state-of-the-art biotech and nanotech equipment for INRS 2Patented research remotely detects nitrogen-rich explosives 2Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
... Most parents of teenage children have experienced frustration at their ... this ubiquitous technology could be used to save lives? At ... nation of Tanzania, a country where few have landlines but ... Joyce Nyoni is trying to do. amfAR, The Foundation ...
... Queen Mary, University of London have discovered how changes to ... a viral infection which is devastating frog populations across the ... being struck down by a foreign virus which is estimated ... UK each year. When it strikes garden ponds, the surrounding ...
... Antonio G. Pisabarro (Professor of Microbiology) as well as ... Genetic and Microbiology Group at the Public University of ... the sequencing of the genome of the Postia ... American National Academy of Sciences, scientific journal ( PNAS ...
Cached Biology News:Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 2Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 3Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 4Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 5Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 6Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 7Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone 8Frog's immune system is key in fight against killer virus 2Genome sequencing of fungus with biotechnological applications 2Genome sequencing of fungus with biotechnological applications 3
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology ... therapies addressing major unmet medical needs using RNA-targeted ... of Allowance from the United States Patent and ... (sd-rxRNA®), for the treatment of fibrosis. The patent ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... Wis. - Gov. Jim Doyle announced Thursday his veto ... human cloning in Wisconsin. , ,The bill would outlaw not ... therapeutic or research cloning, in which an embryo is created ... of harvesting stem cells during the first several days of ...
... the central power station, the phonograph and recorded 1,000 patents, ... cost him millions of dollars and was dubbed Edisons Folly ... Apple Computers, the very company he helped to create. Dean ... of 150 patents, jokes that his biggest failure is that ...
... has completed a public deployment of PV.Web for ... GIS (geographic information systems) maps through the " Land ... , ,Built on ESRI's ArcIMS technology, anyone with a ... on both spatial and non-spatial land information, including transportation ...
Cached Biology Technology:Doyle vetoes cloning ban 2Embracing failure is a necessary step for successful entrepreneurs 2Embracing failure is a necessary step for successful entrepreneurs 3
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 50 ug...
Dog polyclonal to Porcine Pancreatic Islets of Langerhans Cells ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Pig): Sonicated crude membrane fraction of porcine p...
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Biology Products: