Navigation Links
Linking insulin to learning
Date:2/26/2013

rning.

"We hadn't predicted that we would find both positive and negative regulators from these peptides," Zhang said. "Why does the animal need this bidirectional regulation of learning? One possibility is that learning depends on context. There are certain things you want to learn for example, the worms in these experiments wanted to learn that they shouldn't eat this type of infectious bacteria. That's a positive regulation of the learning. But if they needed to eat, even if it is a bad food, to survive, they would need a way to suppress this type of learning."

Even more surprising for Zhang and her colleagues was evidence that the various insulin-like molecules could regulate each other.

"Many animals, including the humans, have multiple insulin-like molecules and it appears that these molecules can act like a network," she said. "Each of them may play a slightly different role in the nervous system, and they function together to coordinate the signaling related to learning and memory. By changing the way the molecules interact, the brain can fine tune learning in a host of different ways."

Going forward, Zhang said she hopes to characterize more of the insulin-like peptides as a way of better understanding how the various molecules interact, and how they act on the neural circuits for learning and memory.

Understanding how such pathways work could one day help in the development of treatment for a host of cognitive disorders, including dementia.

"The signaling pathways for insulin and insulin-like peptides are highly conserved in mammals, including the humans," Zhang said. "There is even some preliminary evidence that insulin treatment, in some cases, can improve cognitive function. That's one reason we believe that if we understand this mechanism, it will help us better understand how insulin pathways are working in the human brain."


'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Linking and lightening: New partnership connects and reveals dark data
2. After decades of research, scientists unlock how insulin interacts with cells
3. Genetic sequencing breakthrough to aid treatment for congenital hyperinsulinism
4. New findings in the search for genetic clues to insulin production
5. Anchoring proteins influence glucose metabolism and insulin release
6. A Kit for increasing insulin production
7. Is there a link between childhood obesity and ADHD, learning disabilities?
8. Learning from the linker
9. Eliminating useless information important to learning, making new memories
10. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
11. Learning whos the top dog: Study reveals how the brain stores information about social rank
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/3/2014)... Ariz. , Dec. 2, 2014 As ... hand readers, Inception Technologies is pleased to announce the ... easier for customers to collect the workforce data that ... problems that have been left by existing readers. Many ... user interface, connectivity and modern technology. Older models force ...
(Date:11/21/2014)... 20, 2014   Atmel® Corporation (NASDAQ: ... and touch technology solutions, today launched the industry,s first ... the widest V cc range from 1.7V to ... faster I 2 C bus communication speeds, and are ... making them ideal for consumer, industrial, computer, and medical ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... This release is available in German . , ... magnetic stimulation, the activity of certain brain nerve cells can ... context has been unclear up to now. Medical experts from ... of Neurophysiology) have now shown that various stimulus patterns changed ...
... womb may protect a newborn infant from developing eczema, ... large trial in Uganda showed that treating a pregnant ... developing the allergic skin disease. Published this week ... the research supports the so-called ,hygiene hypothesis, which proposes ...
... January 2011) -- In Tuesday,s State of the Union address, ... become the first country to have a million electric vehicles ... Vehicles & Personal Transportation Workshop will explore the challenges and ... at the Renaissance Austin (Texas) Hotel on Friday 4 March, ...
Cached Biology News:Learn more quickly by transcranial magnetic brain stimulation 2Learn more quickly by transcranial magnetic brain stimulation 3Learn more quickly by transcranial magnetic brain stimulation 4Exposure to worm infection in the womb may protect against eczema, study suggests 2IEEE-USA workshop to explore the challenges and opportunities of electric vehicle technology 2
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 23, 2014 ... on methyl mercaptan such as its definition, ... also presents product specification, manufacturing process, and ... regions, technology and applications. The analysis also ... survey, marketing channels, industry development trend and ...
(Date:12/24/2014)... Vermillion, Inc. (Nasdaq:   VRML), a ... today that investors including Oracle Investment Management, ... several Vermillion directors have agreed to purchase approximately ... stock and warrants to purchase unregistered shares of ... Under the terms of the private ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 The ... global leader of technical training across the life sciences ... Data Management (SCDM) to provide the organization's members ... programs —providing access to the more than 350 sessions ... members with 10% off when registering for a ...
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
Breaking Biology Technology:Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2
... could soon be prescribing a dose of dark chocolate ... dangerously high blood pressure in their abdomen, according to ... CongressTM 2010, the Annual Meeting of the European Association ... According to the Spanish research, eating dark chocolate reduces ...
... ... super easy! , ... (Vocus) April 15, 2010 -- On a day when paying taxes is on every ... ColeParmer.com will notice a necessary part of checking out—adding shipping costs and taxes—now ...
... ... Niyikiza, Ph.D., Executive Vice President of Development, will present at the BioVisionAlexandria 2010 conference ... ... 14, 2010 -- Clet Niyikiza, Ph.D., Executive Vice President of Development at Merrimack Pharmaceuticals, ...
Cached Biology Technology:Study shows potential benefit of dark chocolate for liver disease patients 2Cole-Parmer Announces Automatic Tax Calculation for Online Purchases 2Clet Niyikiza, Merrimack's Executive Vice President of Development, to Present at BioVisionAlexandria 2010 2
... Mung Bean Nuclease catalyzes the degradation of ... 5-phosphoryl terminated products. While the nuclease prefers ... high concentrations the enzyme degrades double-stranded DNA ... has been used for transcript mapping studies ...
... The S.c. EasyComp Transformation Kit ... transformation-competent Saccharomyces cerevisiae cells. Advantages over ... spheroplast formation or LiCl methods include:- Cells ... than 30 minutes - Competent cell preparation ...
Endomorphin-2. Cross reactivity: Endomorphin-1 3%, Met-enkephalin <0.03%, Leu-enkephalin <0.01% and beta-Endorphin <0.01%....
...
Biology Products: