Navigation Links
Linking insulin to learning
Date:2/26/2013

Though it's most often associated with disorders like diabetes, Harvard researchers have shown how the signaling pathway of insulin and insulin-like peptides plays another critical role in the body helping to regulate learning and memory.

In addition to showing that the insulin-like peptides play a critical role in regulating the activity of neurons involved in learning and memory, a team of researchers led by Yun Zhang, Associate Professor of Organismic and Evolutionary Biology, show that the interaction between the molecules can fine-tune how, or even if, learning takes place. Their work is described in a February 6 paper in Neuron.

"People think of insulin and diabetes, but many metabolic syndromes are associated with some types of cognitive defects and behavioral disorders, like depression or dementia," Zhang said. "That suggests that insulin and insulin-like peptides may play an important role in neural function, but it's been very difficult to nail down the underlying mechanism, because these peptides do not have to function through synapses that connect different neurons in the brain"

To get at that mechanism, Zhang and colleagues turned to an organism whose genome and nervous system are well described and highly accessible by genetics C. elegans.

Using genetic tools, researchers altered the small, transparent worms by removing their ability to create individual insulin-like compounds. These new "mutant" worms were then tested to see whether they would learn to avoid eating a particular type of bacteria that is known to infect the worms. Tests showed that while some worms did learn to steer clear of the bacteria, others didn't suggesting that removing a specific insulin-like compound halted the worms' ability to learn.

Researchers were surprised to find, however, that it wasn't just removing the molecules that could make the animals lose the ability to learn some peptide was found to inhibit learning.

"We hadn't predicted that we would find both positive and negative regulators from these peptides," Zhang said. "Why does the animal need this bidirectional regulation of learning? One possibility is that learning depends on context. There are certain things you want to learn for example, the worms in these experiments wanted to learn that they shouldn't eat this type of infectious bacteria. That's a positive regulation of the learning. But if they needed to eat, even if it is a bad food, to survive, they would need a way to suppress this type of learning."

Even more surprising for Zhang and her colleagues was evidence that the various insulin-like molecules could regulate each other.

"Many animals, including the humans, have multiple insulin-like molecules and it appears that these molecules can act like a network," she said. "Each of them may play a slightly different role in the nervous system, and they function together to coordinate the signaling related to learning and memory. By changing the way the molecules interact, the brain can fine tune learning in a host of different ways."

Going forward, Zhang said she hopes to characterize more of the insulin-like peptides as a way of better understanding how the various molecules interact, and how they act on the neural circuits for learning and memory.

Understanding how such pathways work could one day help in the development of treatment for a host of cognitive disorders, including dementia.

"The signaling pathways for insulin and insulin-like peptides are highly conserved in mammals, including the humans," Zhang said. "There is even some preliminary evidence that insulin treatment, in some cases, can improve cognitive function. That's one reason we believe that if we understand this mechanism, it will help us better understand how insulin pathways are working in the human brain."


'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Related biology news :

1. Linking and lightening: New partnership connects and reveals dark data
2. After decades of research, scientists unlock how insulin interacts with cells
3. Genetic sequencing breakthrough to aid treatment for congenital hyperinsulinism
4. New findings in the search for genetic clues to insulin production
5. Anchoring proteins influence glucose metabolism and insulin release
6. A Kit for increasing insulin production
7. Is there a link between childhood obesity and ADHD, learning disabilities?
8. Learning from the linker
9. Eliminating useless information important to learning, making new memories
10. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
11. Learning whos the top dog: Study reveals how the brain stores information about social rank
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... 27, 2016 Research and Markets has announced ... report to their offering. ... to grow at a CAGR of 12.28% during the ... on an in-depth market analysis with inputs from industry experts. The ... coming years. The report also includes a discussion of the key ...
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Parallel 6 , the leading software as a service ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication ... , Using the CONSULT module, patients and physicians can schedule a face to face ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, ... second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical ... eBook by providing practical tips, tools, and strategies for clinical researchers. , “The ...
Breaking Biology Technology: