Navigation Links
Link to autism in boys found in missing DNA
Date:9/15/2010

September 16, 2010 (Toronto) New research from the Centre for Addiction and Mental Health (CAMH) and The Hospital for Sick Children (SickKids), both in Toronto, Canada provides further clues as to why Autism Spectrum Disorder (ASD) affects four times more males than females. The scientists discovered that males who carry specific alterations of DNA on the sole X-chromosome they carry are at high risk of developing ASD. The research is published in the September 15 issue of Science Translational Medicine.

ASD is a neurological disorder that affects brain functioning, resulting in challenges with communication and social interaction, unusual patterns of behaviour, and often, intellectual deficits. ASD affects one in every 120 children and a startling one in 70 boys. Though all of the causes of ASD are not yet known, research has increasingly pointed towards genetic factors,. In recent years, several genes involved in ASD have successfully been identified.

The research team was led by Dr. John B. Vincent, Senior Scientist and head of CAMH's Molecular Neuropsychiatry and Development Laboratory and Dr. Stephen Scherer, Senior Scientist and Director of The Centre for Applied Genomics at SickKids, and Director of the McLaughlin Centre at the University of Toronto. The scientists analyzed the gene sequences of 2,000 individuals with ASD, along with others with an intellectual disability, and compared the results to thousands of population controls. They found that about one per cent of boys with ASD had mutations in the PTCHD1 gene on the X-chromosome. Similar mutations were not found in thousands of male controls. Also, sisters carrying the same mutation are seemingly unaffected.

"We believe that the PTCHD1 gene has a role in a neurobiological pathway that delivers information to cells during brain development this specific mutation may disrupt crucial developmental processes, contributing to the onset of autism." said Dr. Vincent
'/>"/>

Contact: Michael Torres
media@camh.net
416-595-6015
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. USF receives NIH grant to study implications of maternal infection as cause of autism
2. University of Nevada professor studies structural basis for autism disorders
3. Researchers connect APC protein to autism and mental retardation
4. Autism Speaks on US Senate hearing on potential environmental health factors in autism
5. York U autism-related study discovers how drug interferes with neuronal cell function
6. Autism in a test tube?
7. Autism genome project identifies genetic variants that may make people susceptible to disorder
8. Newly discovered gene variants lead to autism and mental retardation
9. Popular autism diet does not demonstrate behavioral improvement
10. Treatment plan for children with autism often includes complementary therapies
11. Study adds to evidence that autism has genetic basis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability ... disability that occurs when the regions of the ... , The use of non-invasive functional neuroimaging tools ... in dyslexia. However, most prior work has focused ... leaving a gap in our understanding of how ...
(Date:8/28/2014)... of new roads will be built worldwide by 2050. ... wildernesses, where they bring an influx of destructive loggers, ... study has created a ,global roadmap, for prioritising road ... competing demands of development and environmental protection. , The ... that natural importance of ecosystems and a ,road-benefits, layer ...
(Date:8/28/2014)... . Cars, planes ... of sophisticated assembly lines. Mobile assembly carriers, on to which ... assembly lines. In the case of a car body, the ... a precise spatial and chronological sequence, resulting in a complete ... of such an assembly line at molecular level has been ...
Breaking Biology News(10 mins):Dyslexic readers have disrupted network connections in the brain 2Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Nanoscale assembly line 2Nanoscale assembly line 3
... German . What happens if you cannot recall ... name and face of a person, yet you might be unable ... the recall of the information is temporarily impaired. How such associative ... great mysteries of modern neurobiology. Now, scientists from the Max Planck ...
... basis of the most pessimistic and severe scenarios for conditions ... 2080, the oak woods of the Basque Country ... habitat, given that, in our territory, wooded areas will not ... development. Neiker-Tecnalia experts consider that this study illustrates the tendency ...
... scombrids (tunas, bonitos, mackerels and Spanish mackerels) and billfishes ... Red List of Threatened SpeciesTM. Of the 61 known ... at serious risk of extinction. Four species are listed ... in the Least Concern category. The results show ...
Cached Biology News:How memory is read out in the fly brain 2How memory is read out in the fly brain 3Climate change may alter conditions for growth of oak trees in Euskadi 2Increased protection urgently needed for tunas 2Increased protection urgently needed for tunas 3
(Date:8/28/2014)... 28, 2014 The ability for organizations ... that will allow individuals to perform at the highest ... for employers looking to compete in this post–recession era. ... this trend, as the sector increasingly focuses on the ... which will have real results on the organization's development ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
(Date:8/28/2014)... --  SunTrust Robinson Humphrey (STRH) today announced ... equity research team in biotechnology and oilfield services.  ... research demonstrates our commitment to providing our valued ... investment decision making," said Biff Woodruff , ... make significant investments in differentiated content at a ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3BBK Worldwide Leads Sessions at Key September Events 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... has implemented IBM s eServer BladeCenter JS20 as ... proteomics research. IBM announced last month the BladeCenter JS20 ... will begin shipping in volume globally in April 2004. ... Sequest application on the JS20 running SUSE LINUX. Sequest is ...
... the future workforce have recently been issued by the ... think tanks on economic, political and social issues. Both ... are about to change dramatically as a result of ... gain momentum. The result will be a vastly different ...
... Lithuania or Hong Kong what they know about Wisconsin, chances ... beer, brats, cheese or the Green Bay Packers. But how ... if anything. However, its vital to Wisconsins economic future that ... technology assets from its great research institutions to its ...
Cached Biology Technology:Medical College of Wisconsin enhances research with IBM Blade server 2Are you ready to play the new talent management game? 2Are you ready to play the new talent management game? 3When its parts pull together, Wisconsin can tell a compelling economic story 2
... be upgraded to the GenePix Autoloader 4200AL. ... and saves results for up to 36 ... the batch is complete. Line-by-line autofocus ensures ... GenePix Pro gives you complete flexibility to ...
... Maximize the value of your microarray data ... support you need from consultation to extensive ... date methods. Utilize our expertise in combination ... from your own microarray experiments., ,Normalization and ...
... the value of your microarray data ... the support you need from consultation ... most up to date methods. Utilize ... Gene Expression Profiling Service or from ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
Biology Products: