Navigation Links
Link between iron overload and macular degeneration under study
Date:6/24/2010

es sent to the brain via the optic nerve. This is despite multiple built-in safeguards such as filters in the cornea and lens that protect against the most harmful rays, like ultraviolet light, and a yellow pigment that provides extra protection for the most central point of vision. Retinal pigmented epithelial cells, which nourish sight-enabling cells in the retina, help gobble up and dump any resulting tissue trash into the circulation for elimination. Leftovers show up as fatty, yellow deposits called drusen.

Everyone experiences some age-related vision changes and accumulation of harmless levels of drusen, Nussbaum said.

But when byproducts start accumulating under the retinal pigment epithelium, the risk increases for the wet form of macular degeneration in which fragile new blood vessels grow underneath the retina, leak and cloud vision. The question is why some people's condition worsens.

"We see it in one patient and it may stay that way for 20 years. We see it in another patient and within five years their vision has functionally started to decrease," said Dr. Emory Patterson, an MCG School of Medicine graduate completing his ophthalmology residency at MCG who is helping with the clinical study.

Ganapathy first determined that the eye had the means to tightly regulate iron levels. Most organs don't have their own system rather the small intestine regulates absorption of the iron consumed in foods like beans and tofu.

But Ganapathy found the same genetic mutation that causes hemochromatosis in a back layer of the retina, which comes in contact with the blood. A mutation in this HFE gene impairs a protein that regulates iron absorption. The finding in the mouse eye and human retinal pigmented epithelial cells was published in 2004 in Investigative Ophthalmology and Visual Science.

His lab now has animal models for hemochromatosis as well as juvenile hemochromatosis, which is caused by a differe
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Connection elucidated between obesity, salt sensitivity and high blood pressure
2. New link between pollution, temperature and sleep-disordered breathing
3. UAB study confirms link between depression, abdominal obesity
4. JHSPH faculty tackles immune system differences between the sexes
5. Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
6. LSUHSC researcher finds surprising link between sugar in drinks and blood pressure
7. New study reveals link between climate footprints and mass mammal
8. CSHL team helps Neandertal Genome Project compare differences between Neandertals and modern humans
9. Researchers discover genetic link between both types of ALS
10. Biological link between stress, anxiety and depression identified for the first time
11. MSU leads global effort to study link between people, planet
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Link between iron overload and macular degeneration under study
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
(Date:3/31/2015)... YORK , March 31, 2015   Guidepoint ... the launch of the Post-Surgical Pain Management TRACKER, part ... products tracking usage trends in the medical device and ... access to data including treatment volumes, market share, and ... the pain associated with joint surgery. The ...
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... critical security-authentication needs, today announced the beginning of shipments ... solution. The company, based in ... the three-day Connect:ID Expo, which began here today at ... said version 2.0 of its SDK boosts the accuracy ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... memory functions and how memories could potentially be erased ... legal scholars will explore the neuroethics of memory at ... Friday, December 9, at the SUNY Global Center, 116 ... The speakers are Andr A. Fenton, PhD, New ...
... 2011 -- The sharp decrease in global carbon dioxide ... quickly rebounded in 2010, according to research supported by ... of Energy,s Oak Ridge National Laboratory. In ... tons of carbon, compared with 8.6 billion tons in ...
... images from the rocky terrain of Afghanistan,s central highlands have ... thought to have disappeared from the region, according to the ... that provides indisputable proof that the big cat persists in ... prowling around the camera trap,s field of view and investigating ...
Cached Biology News:Carbon dioxide emissions rebound quickly after global financial crisis 2WCS confirms the return of the Persian leopard In Afghanistan's central highlands 2WCS confirms the return of the Persian leopard In Afghanistan's central highlands 3
(Date:5/5/2015)... SAN DIEGO , May 5, 2015 /PRNewswire-USNewswire/ ... treatments for congestive heart failure and other chronic ... create an independent analysis designed to reflect the ... over time. This model will be used to ... for CHF, could have on those groups of ...
(Date:5/5/2015)... 05, 2015 Franz Inc ., the ... announced that its flagship product, AllegroGraph, has been named a ... Market Update report. AllegroGraph is a high performance ... industry standards. Graph databases are skyrocketing in popularity and have ... a recent DBMS ranking by DB-Engines. , “We ...
(Date:5/5/2015)... May 5, 2015   Tocagen Inc. , ... David R. Parkinson , M.D., a venture partner ... to the board of directors of Tocagen. Dr. ... in oncology clinical development, including leading clinical activities ... approvals of the cancer therapeutics Gleevec®, Femara®, Zometa®, ...
(Date:5/5/2015)... The Alliance for Clinical Research Excellence and ... the public interest, and Texas-based for-profit San Antonio ... have formed a strategic alliance to create a blog ... the healthcare and clinical research endeavor. The blog ... the public to be clearly heard in this important ...
Breaking Biology Technology:RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 3ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 4
... of December,Trinitas Comprehensive Cancer Center became one of the ... to offer cancer patients treatment using,RapidArc(TM) radiotherapy technology from ... a fast, precise form of treatment that is delivered ... radiation therapy,technologies. By delivering radiation doses more quickly ...
... Tenn., Jan. 13 Cumberland Pharmaceuticals Inc.,is pleased to ... In,this role, Mr. Lee will draw upon his 24 ... prospective launch and commercialization of,new products for the company. ... ) , "We are ...
... NexBio, a privately held development-stage biopharmaceutical company located in ... Vice President of Corporate Development, will present a corporate ... Francisco, CA, on January 14, 2009 at 2:15pm. ... improve the quality of life by creating and commercializing ...
Cached Biology Technology:Trinitas Comprehensive Cancer Center Now Offering Cancer Patients Faster, Ultra-Precise Radiation Using New RapidArc Technology 2Trinitas Comprehensive Cancer Center Now Offering Cancer Patients Faster, Ultra-Precise Radiation Using New RapidArc Technology 3NexBio to Present at 2009 Biotech Showcase 2NexBio to Present at 2009 Biotech Showcase 3
... L sample. Ideal for small volume applications, including pediatric, neonatal, geriatric, general adult, veterinary and experimental ... 3 minutes after turn-on. ... ... ...
Human/Mouse/Rat LAR Affinity Purified PAb...
X-Gal (5-Bromo-4-Chloro-3-Indoyl-beta -D-Galactopyranoside)...
APG5 autophagy 5-like (S. cerevisiae)...
Biology Products: