Navigation Links
Link between iron overload and macular degeneration under study
Date:6/24/2010

es sent to the brain via the optic nerve. This is despite multiple built-in safeguards such as filters in the cornea and lens that protect against the most harmful rays, like ultraviolet light, and a yellow pigment that provides extra protection for the most central point of vision. Retinal pigmented epithelial cells, which nourish sight-enabling cells in the retina, help gobble up and dump any resulting tissue trash into the circulation for elimination. Leftovers show up as fatty, yellow deposits called drusen.

Everyone experiences some age-related vision changes and accumulation of harmless levels of drusen, Nussbaum said.

But when byproducts start accumulating under the retinal pigment epithelium, the risk increases for the wet form of macular degeneration in which fragile new blood vessels grow underneath the retina, leak and cloud vision. The question is why some people's condition worsens.

"We see it in one patient and it may stay that way for 20 years. We see it in another patient and within five years their vision has functionally started to decrease," said Dr. Emory Patterson, an MCG School of Medicine graduate completing his ophthalmology residency at MCG who is helping with the clinical study.

Ganapathy first determined that the eye had the means to tightly regulate iron levels. Most organs don't have their own system rather the small intestine regulates absorption of the iron consumed in foods like beans and tofu.

But Ganapathy found the same genetic mutation that causes hemochromatosis in a back layer of the retina, which comes in contact with the blood. A mutation in this HFE gene impairs a protein that regulates iron absorption. The finding in the mouse eye and human retinal pigmented epithelial cells was published in 2004 in Investigative Ophthalmology and Visual Science.

His lab now has animal models for hemochromatosis as well as juvenile hemochromatosis, which is caused by a differe
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Connection elucidated between obesity, salt sensitivity and high blood pressure
2. New link between pollution, temperature and sleep-disordered breathing
3. UAB study confirms link between depression, abdominal obesity
4. JHSPH faculty tackles immune system differences between the sexes
5. Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
6. LSUHSC researcher finds surprising link between sugar in drinks and blood pressure
7. New study reveals link between climate footprints and mass mammal
8. CSHL team helps Neandertal Genome Project compare differences between Neandertals and modern humans
9. Researchers discover genetic link between both types of ALS
10. Biological link between stress, anxiety and depression identified for the first time
11. MSU leads global effort to study link between people, planet
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Link between iron overload and macular degeneration under study
(Date:7/29/2014)... that brings together two of the major disciplines behind ... insect fossils through stunning photographs and unique illustrations. , ... Jepson, details the incredible preservation and diversity of fossilised ... what these remarkable fossils can tell us about the ... our planet. Like the mosquito in Jurassic Park, many ...
(Date:7/28/2014)... new discovery of two additional coral communities showing signs of ... footprint of the 2010 spill in the Gulf of Mexico. ... Fisher, professor of biology at Penn State University. A paper ... corals in the Gulf of Mexico will be published during ... Edition of the journal Proceedings of the National Academy ...
(Date:7/28/2014)... John Essigmann and colleagues from the University of Washington had ... they could induce the virus to mutate uncontrollably, they could ... strategy that our immune system uses against many viruses. ... to mutate at an enhanced rate, as expected. But it ... clinical trial reported in 2011. In a new study, however, ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4
... have experienced rotator cuff tears are at increased risk of ... the May 2009 issue of The Journal of Bone ... genetic predisposition as a possible cause for rotator cuff disease," ... University of Utah School of Medicine Orthopaedic Center in Salt ...
... of scientists from Canada, Spain and the United States has ... against environmental stresses like drought, freezing and heat. ... signal adverse conditions and help them adapt," says team member ... the University of Toronto. "If we can control these ...
... cleared tens of thousands of square miles of forests to ... popular food ingredient. Ancient peatlands have been drained and lush ... landscape of equatorial Asia now lies vulnerable to fires, which ... the air as well as the land. A team ...
Cached Biology News:Rotator cuff tears: Are they all in the family? 2International team finds key gene that allows plants to survive drought 2NASA study says climate adds fuel to Asian wildfire emissions 2NASA study says climate adds fuel to Asian wildfire emissions 3NASA study says climate adds fuel to Asian wildfire emissions 4
(Date:7/29/2014)... Tenn. (PRWEB) July 29, 2014 ... in biomass feedstock supply innovation and supply chain ... proprietary feedstock management systems, Energy Grange™ and Supply ... of R&D and in-the-field testing aimed at consolidating ... offering benefits to landowners, farmers and feedstock end ...
(Date:7/29/2014)... G-CON Manufacturing Inc., the standard in design and ... leadership appointment designed to drive the company’s ambitious growth ... Maik Jornitz, Chief Operating Officer of G-Con Manufacturing, has ... the pioneering company through its next phase of market ... and look forward to providing our next generation of ...
(Date:7/29/2014)... July 29, 2014 White papers ... and cloud based eClinical technologies, have been published by ... These follow a long line of white papers by ... including Life Science Leader, Pharmaceutical Online, and OpenHealthNews. , ... a paper by CTO Marc Desgrousilliers, 'The Five ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 The Workgroup ... authority on the use of health IT to create ... Health Plan Identifier (HPID) Workgroup has developed an ... Health Plan and Payer?” The HPID Workgroup, a part ... with the Centers for Medicare and Medicaid Services (CMS) ...
Breaking Biology Technology:Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2
... Ind., Jan. 23 Zimmer Holdings, Inc.,(NYSE: ZMH ... announced,today it will be participating in the Wachovia Securities ... 10:15 a.m. Eastern Time., A live webcast of ... at http://investor.zimmer.com . The webcast will,be archived for ...
... QED International Associates, Inc.,administrator for the HealthShares(TM) ... HealthShares(TM) Exchange-Traded Funds, today announced,that effective at the ... Pharmaceuticals Inc. (Nasdaq: REGN ) will replace ... HealthShares(TM) Composite Index. MGI Pharma is being,acquired by ...
... 23 /PRNewswire/ - Dalton Medicinal Chemistry Partners,the ... announces that it,has achieved another targeted milestone ... (Canada) Ltd., Dalton Medicinal Chemistry Partners ... and synthesize novel compounds against an,antiviral target ...
Cached Biology Technology:QED International Associates Announces Changes to the HealthShares(TM) Composite, HealthShares(TM) Cancer and HealthShares(TM) Neuroscience Indexes 2
Mouse monoclonal to Factor V Heavy Chain Immunogen: Purified human Factor V. Specificity: This antibody reacts with the activation C peptide (mw ~150,000) in the heavy chain of thrombin-cleave...
Mouse monoclonal [15-2] to Mannose Receptor (Biotin) ( Abpromise for all tested applications). entrezGeneID: 4360 SwissProtID: P22897...
SAPK/JNK Antibody...
Tris-EDTA Buffer Solution, 1X, pH 8.0, sterile, Molecular Biology Grade...
Biology Products: