Navigation Links
Link between iron overload and macular degeneration under study
Date:6/24/2010

AUGUSTA, Ga. - The most common and under-diagnosed genetic disease in humans just may be a cause of the worst form of macular degeneration, Medical College of Georgia researchers report.

They are pursuing a link between hemochromatosis, which results in iron overload, and the wet form of macular degeneration, the leading cause of blindness in people 60 and older. They suspect that too much iron, known to wreak cumulative havoc on the body's organs, hastens normal aging of the eyes.

If they are correct, avoiding the most severe consequences of a disease that robs the central vision could be as simple as donating blood a couple times annually to reduce iron levels, said Dr. Vadivel Ganapathy, chairman of the MCG School of Medicine Department of Biochemistry and Molecular Biology.

A $1.5 million grant from the National Eye Institute is enabling the MCG scientists to define the impact of hemochromatosis on the eye's form and function. Support from MCG's Vision Discovery Institute is enabling screening for its causative genetic mutation in the blood of healthy individuals and those with macular degeneration.

"If this is a predisposing risk for macular degeneration, we have a very useful tool for screening patients," said Dr. Julian Nussbaum, a retinal specialist who chairs the School of Medicine's Department of Ophthalmology and co-directs MCG's Vision Discovery Institute. "We can give patients information right off the bat that may help them."

While linking iron overload to eye disease may seem odd, they have in common the result of too much of a good thing. The eyes need light to see and the body needs iron to deliver oxygen but the price of both is increased oxidative stress, Ganapathy said. "You need oxygen and you need iron to make this bad molecule," he said of oxygen radicals that can destroy tissue down to the DNA.

Light alone takes a slow toll on the retina, which converts it into electrical impuls
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Connection elucidated between obesity, salt sensitivity and high blood pressure
2. New link between pollution, temperature and sleep-disordered breathing
3. UAB study confirms link between depression, abdominal obesity
4. JHSPH faculty tackles immune system differences between the sexes
5. Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
6. LSUHSC researcher finds surprising link between sugar in drinks and blood pressure
7. New study reveals link between climate footprints and mass mammal
8. CSHL team helps Neandertal Genome Project compare differences between Neandertals and modern humans
9. Researchers discover genetic link between both types of ALS
10. Biological link between stress, anxiety and depression identified for the first time
11. MSU leads global effort to study link between people, planet
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Link between iron overload and macular degeneration under study
(Date:9/17/2014)... from the Copenhagen Centre for Social Evolution and Yale ... that birth weight and -length can partially predict the ... as autism and schizophrenia later in life. The study ... subsequent hospital diagnoses for up to 30 years, and ... study is published today in the Proceedings of ...
(Date:9/17/2014)... the human retinoblastoma protein gene are a leading cause ... turned to fruit fly eyes to unlock the secrets ... paper featured on the cover of the current issue ... State University researchers provide the first detailed examination of ... the human cancer gene, said Irina Pushel, MSU undergraduate ...
(Date:9/17/2014)... 1960s. The typical development phases of trees and stands ... as much as 70 percent. This was the outcome ... Universitt Mnchen based on long-term data from experimental forest ... findings were published recently in Nature Communications . ... topic, with the very survival of large forest ecosystems ...
Breaking Biology News(10 mins):Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Abnormal properties of cancer protein revealed in fly eyes 2Global change: Trees continue to grow at a faster rate 2Global change: Trees continue to grow at a faster rate 3
... York University and Rockefeller University have discovered that ... have key roles in gene regulation, can team ... are a recently discovered large class of regulatory, ... in target messenger RNA to regulate their stability ...
... natural process that repairs damage to the human ... has helped establish a method of gene therapy ... disease-causing genes. , The findings are available online ... repair process known as homologous recombination, Dr. Matthew ...
... that allows immune cells known as neutrophils to protect ... at Washington University School of Medicine in St. Louis ... the development of an arthritis-like disorder by making the ... newly identified role for the gene, Foxo3a, may open ...
Cached Biology News:NYU, Rockefeller researchers find complexity of regulation by microRNA genes 2Researchers pioneer new gene therapy technique using natural repair process 2Researchers pioneer new gene therapy technique using natural repair process 3Disabling gene defuses rheumatoid arthritis in mice 2Disabling gene defuses rheumatoid arthritis in mice 3
(Date:9/17/2014)... The Pistoia Alliance, a global not ... to innovation in life sciences R&D through pre-competitive ... as Executive Director Business Development North America, as ... , Carmen joins the Pistoia Alliance from Accelrys ... Accelrys, she managed various life sciences and material ...
(Date:9/16/2014)... September 16, 2014 “Nature has developed, ... features that we desire in optical design,” said Joseph ... State University. “As we explore surfaces and structures at ... lessons were presented in San Diego in August during ... in Nature ” chaired by Shaw and Rongguang Liang ...
(Date:9/16/2014)... chin strap that can harvest energy from jaw movements ... Canada. , It is hoped that the device can ... a number of small-scale implantable or wearable electronic devices, ... and communication devices. , The first results of the ... IOP Publishing,s journal Smart Materials and Structures . ...
(Date:9/16/2014)... D.C., September 16, 2014 --The emerging field of ... to the next level, enabling the construction of ... efficient devices, individual molecules would take on the ... transistors. , A team of researchers from five ... candidate for use in small-scale electronics: a molecule ...
Breaking Biology Technology:Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5'Smart material' chin strap harvests energy from chewing 2The future face of molecular electronics 2
... the Nobel Prize shows a cat resting in a ... around graphene, which, at one atom thick, is the ... A significant obstacle to realizing graphene,s potential lies in ... sleeping cat. For now, material scientists stitch individual graphene ...
... Professor Federico Rosei of the INRS Energy Materials ... the prestigious 2010 Friedrich Wilhelm Bessel Research Award given ... 25 of these awards annually to young, high level ... recognition of the caliber and scope of his research ...
... ... ... ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; ...
Cached Biology Technology:Graphene's strength lies in its defects 2INRS professor Federico Rosei receives a 2010 Friedrich Wilhelm Bessel Research Award 2YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 2YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 3YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 4YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 5YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 6YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 7YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 8YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 9YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 10YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 11YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 12YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 13YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 14